Allopurinol reduces brachial and central blood pressure, and carotid intima-media thickness progression after ischaemic stroke and transient ischaemic attack: a randomised controlled trial

Objective Central blood pressure (CBP) and carotid intima-media thickness (CIMT) are surrogate measures of cardiovascular risk. Allopurinol reduces serum uric acid and oxidative stress and improves endothelial function and may therefore reduce CBP and CIMT progression. This study sought to ascertain...

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Veröffentlicht in:	Heart (British Cardiac Society) 2014-07, Vol.100 (14), p.1085-1092
Hauptverfasser:	Higgins, P, Walters, M R, Murray, H M, McArthur, K, McConnachie, A, Lees, K R, Dawson, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Allopurinol - therapeutic use Antihypertensive Agents - therapeutic use Blood pressure Blood Pressure - drug effects Body Mass Index Brachial Artery - physiopathology Brain Ischemia - complications Cardiovascular disease Carotid Intima-Media Thickness Coronary vessels Disease Progression Double-Blind Method Female Follow-Up Studies Health risk assessment Humans Inflammation Ischemic Attack, Transient - drug therapy Male Middle Aged Risk Factors Rodents Smoking - adverse effects Stroke Stroke - drug therapy Stroke - etiology Studies Treatment Outcome Uric acid
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