Relationship Between Diclofenac Dose and Risk of Gastrointestinal and Cardiovascular Events: Meta-Regression Based on Two Systematic Literature Reviews

Abstract Background NSAIDs are associated with risks of gastrointestinal (GI) and cardiovascular (CV) toxicities. It has been reported that the risks of GI and CV events are dose related, resulting in guidance explicitly emphasizing the use of NSAIDs at the lowest effective dose for the shortest dur...

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Veröffentlicht in:	Clinical therapeutics 2014-06, Vol.36 (6), p.906-917
Hauptverfasser:	Odom, Dawn M., MS, Mladsi, Deirdre M., BA, Saag, Kenneth G., MD, MSc, Sherif, Bintu N., MS, Miles, LaStella, MS, Ronquest, Naoko, PhD, Wang, Jianmin, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - adverse effects Biological and medical sciences Cardiovascular Diseases - chemically induced cardiovascular safety diclofenac Diclofenac - administration & dosage Diclofenac - adverse effects dose-related toxicity Dose-Response Relationship, Drug Drug dosages Drug therapy gastrointestinal complications Gastrointestinal Diseases - chemically induced Heart attacks Hemorrhage Humans Internal Medicine Medical Education Medical sciences meta-analysis Middle Aged Pain Pharmacology. Drug treatments Risk Assessment Studies Ulcers
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