The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans

Chromosomal mosaicism, the presence of two or more distinct cell lines, is prevalent throughout human pre- and post-implantation development and can lead to genetic abnormalities, miscarriages, stillbirths or live births. Due to the prevalence and significance of mosaicism in the human species, it i...

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Veröffentlicht in:	Human reproduction update 2014-07, Vol.20 (4), p.571-581
Hauptverfasser:	Taylor, Tyl H, Gitlin, Susan A, Patrick, Jennifer L, Crain, Jack L, Wilson, J Michael, Griffin, Darren K
Format:	Artikel
Sprache:	eng
Schlagworte:	Blastocyst - physiology Cell Lineage - physiology Chromosome Disorders - etiology Cleavage Stage, Ovum - physiology Embryo Implantation - physiology Embryonic Development - genetics Fathers Fertilization in Vitro - adverse effects Humans Mosaicism Mothers Preimplantation Diagnosis - methods
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