Characterization of the attenuation of breast cancer bone metastasis in mice by zoledronic acid using (99m)Tc bone scintigraphy
Metastatic breast cancer often metastasizes to bone. The purposes of the study were (1) to evaluate the use of (99m)Tc-MDP bone scintigraphy for detection of metastatic bone lesions, and (2) to determine the efficacy of zoledronic acid in mice with breast cancer bone metastasis. All tumor-bearing mi...
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| Veröffentlicht in: | Pathology oncology research 2014-07, Vol.20 (3), p.747-754 |
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| creator | Wu, Chunyu Yang, Shunfang Sun, Zhenping Han, Xianghui Ye, Yiyi Liu, Sheng |
| description | Metastatic breast cancer often metastasizes to bone. The purposes of the study were (1) to evaluate the use of (99m)Tc-MDP bone scintigraphy for detection of metastatic bone lesions, and (2) to determine the efficacy of zoledronic acid in mice with breast cancer bone metastasis. All tumor-bearing mice were analyzed with radionuclide bone scintigraphy, X-ray, and histological analysis. The metastatic bone tissue was also harvested and analyzed by western blotting and real-time qPCR. Interestingly, zoledronic acid significantly decreased both the tumor burden and the incidence of bone metastasis in mice. In addition, histomorphometric, stereological, and molecular biology analyses demonstrated that zoledronic acid may function to inhibit breast cancer cell growth in the bone microenvironment and regulate the function of osteoblasts and osteoclasts in tumor-bearing mice. Finally, the attenuation of breast cancer bone metastasis using zoledronic acid can be accurately characterized by (99m)Tc bone scintigraphy in mice. |
| doi_str_mv | 10.1007/s12253-014-9756-z |
| format | Article |
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The purposes of the study were (1) to evaluate the use of (99m)Tc-MDP bone scintigraphy for detection of metastatic bone lesions, and (2) to determine the efficacy of zoledronic acid in mice with breast cancer bone metastasis. All tumor-bearing mice were analyzed with radionuclide bone scintigraphy, X-ray, and histological analysis. The metastatic bone tissue was also harvested and analyzed by western blotting and real-time qPCR. Interestingly, zoledronic acid significantly decreased both the tumor burden and the incidence of bone metastasis in mice. In addition, histomorphometric, stereological, and molecular biology analyses demonstrated that zoledronic acid may function to inhibit breast cancer cell growth in the bone microenvironment and regulate the function of osteoblasts and osteoclasts in tumor-bearing mice. 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The purposes of the study were (1) to evaluate the use of (99m)Tc-MDP bone scintigraphy for detection of metastatic bone lesions, and (2) to determine the efficacy of zoledronic acid in mice with breast cancer bone metastasis. All tumor-bearing mice were analyzed with radionuclide bone scintigraphy, X-ray, and histological analysis. The metastatic bone tissue was also harvested and analyzed by western blotting and real-time qPCR. Interestingly, zoledronic acid significantly decreased both the tumor burden and the incidence of bone metastasis in mice. In addition, histomorphometric, stereological, and molecular biology analyses demonstrated that zoledronic acid may function to inhibit breast cancer cell growth in the bone microenvironment and regulate the function of osteoblasts and osteoclasts in tumor-bearing mice. 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Yang, Shunfang ; Sun, Zhenping ; Han, Xianghui ; Ye, Yiyi ; Liu, Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-da1cbf651196678351628a0f7229e1bebd27026a60518dc986f0829d1eae9313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Blotting, Western</topic><topic>Bone Density Conservation Agents - therapeutic use</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - prevention & control</topic><topic>Bone Neoplasms - secondary</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - prevention & control</topic><topic>Diphosphonates - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Imidazoles - therapeutic use</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>Technetium Tc 99m Medronate</topic><topic>Tumor Cells, Cultured</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Chunyu</creatorcontrib><creatorcontrib>Yang, Shunfang</creatorcontrib><creatorcontrib>Sun, Zhenping</creatorcontrib><creatorcontrib>Han, Xianghui</creatorcontrib><creatorcontrib>Ye, Yiyi</creatorcontrib><creatorcontrib>Liu, Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Chunyu</au><au>Yang, Shunfang</au><au>Sun, Zhenping</au><au>Han, Xianghui</au><au>Ye, Yiyi</au><au>Liu, Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the attenuation of breast cancer bone metastasis in mice by zoledronic acid using (99m)Tc bone scintigraphy</atitle><jtitle>Pathology oncology research</jtitle><addtitle>Pathol Oncol Res</addtitle><date>2014-07</date><risdate>2014</risdate><volume>20</volume><issue>3</issue><spage>747</spage><epage>754</epage><pages>747-754</pages><eissn>1532-2807</eissn><abstract>Metastatic breast cancer often metastasizes to bone. The purposes of the study were (1) to evaluate the use of (99m)Tc-MDP bone scintigraphy for detection of metastatic bone lesions, and (2) to determine the efficacy of zoledronic acid in mice with breast cancer bone metastasis. All tumor-bearing mice were analyzed with radionuclide bone scintigraphy, X-ray, and histological analysis. The metastatic bone tissue was also harvested and analyzed by western blotting and real-time qPCR. Interestingly, zoledronic acid significantly decreased both the tumor burden and the incidence of bone metastasis in mice. In addition, histomorphometric, stereological, and molecular biology analyses demonstrated that zoledronic acid may function to inhibit breast cancer cell growth in the bone microenvironment and regulate the function of osteoblasts and osteoclasts in tumor-bearing mice. Finally, the attenuation of breast cancer bone metastasis using zoledronic acid can be accurately characterized by (99m)Tc bone scintigraphy in mice.</abstract><cop>Netherlands</cop><pmid>24610002</pmid><doi>10.1007/s12253-014-9756-z</doi><tpages>8</tpages></addata></record> |
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| ispartof | Pathology oncology research, 2014-07, Vol.20 (3), p.747-754 |
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| subjects | Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Bone Density Conservation Agents - therapeutic use Bone Neoplasms - diagnostic imaging Bone Neoplasms - prevention & control Bone Neoplasms - secondary Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Breast Neoplasms - prevention & control Diphosphonates - therapeutic use Female Humans Imidazoles - therapeutic use Mice Mice, Inbred BALB C Mice, Nude Radionuclide Imaging Radiopharmaceuticals Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Technetium Tc 99m Medronate Tumor Cells, Cultured Xenograft Model Antitumor Assays |
| title | Characterization of the attenuation of breast cancer bone metastasis in mice by zoledronic acid using (99m)Tc bone scintigraphy |
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