Breast cancer screening halves the risk of breast cancer death: A case-referent study
Abstract Large-scale epidemiologic studies have consistently demonstrated the effectiveness of mammographic screening programs, however the benefits are still subject to debate. We estimated the effect of the Dutch screening program on breast cancer mortality. In a large multi-region case-referent s...
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| Veröffentlicht in: | Breast (Edinburgh) 2014-08, Vol.23 (4), p.439-444 |
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| creator | Paap, Ellen Verbeek, André L.M Botterweck, Anita A.M van Doorne-Nagtegaal, Heidi J Imhof-Tas, Mechli de Koning, Harry J Otto, Suzie J de Munck, Linda van der Steen, Annemieke Holland, Roland den Heeten, Gerard J Broeders, Mireille J.M |
| description | Abstract Large-scale epidemiologic studies have consistently demonstrated the effectiveness of mammographic screening programs, however the benefits are still subject to debate. We estimated the effect of the Dutch screening program on breast cancer mortality. In a large multi-region case-referent study, we identified all breast cancer deaths in 2004 and 2005 in women aged 50–75 who had been invited for screening (cases). Cases were individually matched to referents from the population invited to screening. Conditional logistic regression was used to estimate the odds ratio (OR) of breast cancer death according to individual screening history. The OR was adjusted for self-selection bias using regional correction factors for the difference in baseline risk for breast cancer death between screened and unscreened women. A total of 1233 cases and 2090 referents were included in this study. We found a 58% reduction in breast cancer mortality in screened versus unscreened women (adjusted OR = 0.42, 95% CI 0.33–0.53). Screening, i.e. early detection and treatment, has resulted in a substantial reduction in breast cancer mortality, indicating that the Dutch breast cancer screening program is highly effective. |
| doi_str_mv | 10.1016/j.breast.2014.03.002 |
| format | Article |
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We estimated the effect of the Dutch screening program on breast cancer mortality. In a large multi-region case-referent study, we identified all breast cancer deaths in 2004 and 2005 in women aged 50–75 who had been invited for screening (cases). Cases were individually matched to referents from the population invited to screening. Conditional logistic regression was used to estimate the odds ratio (OR) of breast cancer death according to individual screening history. The OR was adjusted for self-selection bias using regional correction factors for the difference in baseline risk for breast cancer death between screened and unscreened women. A total of 1233 cases and 2090 referents were included in this study. We found a 58% reduction in breast cancer mortality in screened versus unscreened women (adjusted OR = 0.42, 95% CI 0.33–0.53). Screening, i.e. early detection and treatment, has resulted in a substantial reduction in breast cancer mortality, indicating that the Dutch breast cancer screening program is highly effective.</description><identifier>ISSN: 0960-9776</identifier><identifier>EISSN: 1532-3080</identifier><identifier>DOI: 10.1016/j.breast.2014.03.002</identifier><identifier>PMID: 24713277</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; Breast cancer ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - mortality ; Case-Control Studies ; Case-referent study ; Early Detection of Cancer - mortality ; Effectiveness ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Logistic Models ; Mammography ; Middle Aged ; Screening</subject><ispartof>Breast (Edinburgh), 2014-08, Vol.23 (4), p.439-444</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-eb21172d22e526145c4a59d0e6072adfe2841de04219946ca78b567409f5b2473</citedby><cites>FETCH-LOGICAL-c463t-eb21172d22e526145c4a59d0e6072adfe2841de04219946ca78b567409f5b2473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.breast.2014.03.002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24713277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paap, Ellen</creatorcontrib><creatorcontrib>Verbeek, André L.M</creatorcontrib><creatorcontrib>Botterweck, Anita A.M</creatorcontrib><creatorcontrib>van Doorne-Nagtegaal, Heidi J</creatorcontrib><creatorcontrib>Imhof-Tas, Mechli</creatorcontrib><creatorcontrib>de Koning, Harry J</creatorcontrib><creatorcontrib>Otto, Suzie J</creatorcontrib><creatorcontrib>de Munck, Linda</creatorcontrib><creatorcontrib>van der Steen, Annemieke</creatorcontrib><creatorcontrib>Holland, Roland</creatorcontrib><creatorcontrib>den Heeten, Gerard J</creatorcontrib><creatorcontrib>Broeders, Mireille J.M</creatorcontrib><title>Breast cancer screening halves the risk of breast cancer death: A case-referent study</title><title>Breast (Edinburgh)</title><addtitle>Breast</addtitle><description>Abstract Large-scale epidemiologic studies have consistently demonstrated the effectiveness of mammographic screening programs, however the benefits are still subject to debate. We estimated the effect of the Dutch screening program on breast cancer mortality. In a large multi-region case-referent study, we identified all breast cancer deaths in 2004 and 2005 in women aged 50–75 who had been invited for screening (cases). Cases were individually matched to referents from the population invited to screening. Conditional logistic regression was used to estimate the odds ratio (OR) of breast cancer death according to individual screening history. The OR was adjusted for self-selection bias using regional correction factors for the difference in baseline risk for breast cancer death between screened and unscreened women. A total of 1233 cases and 2090 referents were included in this study. We found a 58% reduction in breast cancer mortality in screened versus unscreened women (adjusted OR = 0.42, 95% CI 0.33–0.53). Screening, i.e. early detection and treatment, has resulted in a substantial reduction in breast cancer mortality, indicating that the Dutch breast cancer screening program is highly effective.</description><subject>Aged</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - mortality</subject><subject>Case-Control Studies</subject><subject>Case-referent study</subject><subject>Early Detection of Cancer - mortality</subject><subject>Effectiveness</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Mammography</subject><subject>Middle Aged</subject><subject>Screening</subject><issn>0960-9776</issn><issn>1532-3080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EokvhP0DIRy4J44_YCQektuJLqsQBerYce8J6m02KJ6m0_z1etiDBhZM10ntvPL_H2EsBtQBh3uzqPqOnpZYgdA2qBpCP2EY0SlYKWnjMNtAZqDprzRl7RrQDgE6Z9ik7k9oKJa3dsJvLXyE8-Clg5hQy4pSm73zrx3skvmyR50S3fB54_5c0ol-2b_lFmQmrjANmnBZOyxoPz9mTwY-ELx7ec3bz4f23q0_V9ZePn68urqugjVoq7KUQVkYpsZFG6CZo33QR0ICVPg4oWy0igpai67QJ3rZ9Y6yGbmj6coM6Z69PuXd5_rEiLW6fKOA4-gnnlVyBUXytAV2k-iQNeSYq33V3Oe19PjgB7gjU7dzpQHcE6kC5ArTYXj1sWPs9xj-m3wSL4N1JgOXO-4TZUUhYCMWUMSwuzul_G_4NCGOaUvDjLR6QdvOap8LQCUfSgft6LPXYqdClT21A_QTY6Jwb</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Paap, Ellen</creator><creator>Verbeek, André L.M</creator><creator>Botterweck, Anita A.M</creator><creator>van Doorne-Nagtegaal, Heidi J</creator><creator>Imhof-Tas, Mechli</creator><creator>de Koning, Harry J</creator><creator>Otto, Suzie J</creator><creator>de Munck, Linda</creator><creator>van der Steen, Annemieke</creator><creator>Holland, Roland</creator><creator>den Heeten, Gerard J</creator><creator>Broeders, Mireille J.M</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Breast cancer screening halves the risk of breast cancer death: A case-referent study</title><author>Paap, Ellen ; Verbeek, André L.M ; Botterweck, Anita A.M ; van Doorne-Nagtegaal, Heidi J ; Imhof-Tas, Mechli ; de Koning, Harry J ; Otto, Suzie J ; de Munck, Linda ; van der Steen, Annemieke ; Holland, Roland ; den Heeten, Gerard J ; Broeders, Mireille J.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-eb21172d22e526145c4a59d0e6072adfe2841de04219946ca78b567409f5b2473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - mortality</topic><topic>Case-Control Studies</topic><topic>Case-referent study</topic><topic>Early Detection of Cancer - mortality</topic><topic>Effectiveness</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Mammography</topic><topic>Middle Aged</topic><topic>Screening</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paap, Ellen</creatorcontrib><creatorcontrib>Verbeek, André L.M</creatorcontrib><creatorcontrib>Botterweck, Anita A.M</creatorcontrib><creatorcontrib>van Doorne-Nagtegaal, Heidi J</creatorcontrib><creatorcontrib>Imhof-Tas, Mechli</creatorcontrib><creatorcontrib>de Koning, Harry J</creatorcontrib><creatorcontrib>Otto, Suzie J</creatorcontrib><creatorcontrib>de Munck, Linda</creatorcontrib><creatorcontrib>van der Steen, Annemieke</creatorcontrib><creatorcontrib>Holland, Roland</creatorcontrib><creatorcontrib>den Heeten, Gerard J</creatorcontrib><creatorcontrib>Broeders, Mireille J.M</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paap, Ellen</au><au>Verbeek, André L.M</au><au>Botterweck, Anita A.M</au><au>van Doorne-Nagtegaal, Heidi J</au><au>Imhof-Tas, Mechli</au><au>de Koning, Harry J</au><au>Otto, Suzie J</au><au>de Munck, Linda</au><au>van der Steen, Annemieke</au><au>Holland, Roland</au><au>den Heeten, Gerard J</au><au>Broeders, Mireille J.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breast cancer screening halves the risk of breast cancer death: A case-referent study</atitle><jtitle>Breast (Edinburgh)</jtitle><addtitle>Breast</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>23</volume><issue>4</issue><spage>439</spage><epage>444</epage><pages>439-444</pages><issn>0960-9776</issn><eissn>1532-3080</eissn><abstract>Abstract Large-scale epidemiologic studies have consistently demonstrated the effectiveness of mammographic screening programs, however the benefits are still subject to debate. We estimated the effect of the Dutch screening program on breast cancer mortality. In a large multi-region case-referent study, we identified all breast cancer deaths in 2004 and 2005 in women aged 50–75 who had been invited for screening (cases). Cases were individually matched to referents from the population invited to screening. Conditional logistic regression was used to estimate the odds ratio (OR) of breast cancer death according to individual screening history. The OR was adjusted for self-selection bias using regional correction factors for the difference in baseline risk for breast cancer death between screened and unscreened women. A total of 1233 cases and 2090 referents were included in this study. We found a 58% reduction in breast cancer mortality in screened versus unscreened women (adjusted OR = 0.42, 95% CI 0.33–0.53). 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| subjects | Aged Breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - mortality Case-Control Studies Case-referent study Early Detection of Cancer - mortality Effectiveness Female Hematology, Oncology and Palliative Medicine Humans Logistic Models Mammography Middle Aged Screening |
| title | Breast cancer screening halves the risk of breast cancer death: A case-referent study |
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