Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity
Discordance between fractional flow reserve (FFR) and coronary flow velocity reserve (CFVR) may reflect important coronary pathophysiology but usually remains unnoticed in clinical practice. We evaluated the physiological basis and clinical outcome associated with FFR/CFVR discordance. We studied 15...
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| Veröffentlicht in: | Circulation. Cardiovascular interventions 2014-06, Vol.7 (3), p.301-311 |
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| creator | van de Hoef, Tim P van Lavieren, Martijn A Damman, Peter Delewi, Ronak Piek, Martijn A Chamuleau, Steven A J Voskuil, Michiel Henriques, José P S Koch, Karel T de Winter, Robbert J Spaan, Jos A E Siebes, Maria Tijssen, Jan G P Meuwissen, Martijn Piek, Jan J |
| description | Discordance between fractional flow reserve (FFR) and coronary flow velocity reserve (CFVR) may reflect important coronary pathophysiology but usually remains unnoticed in clinical practice. We evaluated the physiological basis and clinical outcome associated with FFR/CFVR discordance.
We studied 157 intermediate coronary stenoses in 157 patients, evaluated by FFR and CFVR between April 1997 and September 2006 in which revascularization was deferred. Long-term follow-up was performed to document the occurrence of major adverse cardiac events: cardiac death, myocardial infarction, or target vessel revascularization. Discordance between FFR and CFVR occurred in 31% and 37% of stenoses at the 0.75, and 0.80 FFR cut-off value, respectively, and was characterized by microvascular resistances during basal and hyperemic conditions. Follow-up duration amounted to 11.7 years (Q1-Q3, 9.9-13.3 years). Compared with concordant normal results of FFR and CFVR, a normal FFR with an abnormal CFVR was associated with significantly increased major adverse cardiac events rate throughout 10 years of follow-up, regardless of the FFR cut-off applied. In contrast, an abnormal FFR with a normal CFVR was associated with equivalent clinical outcome compared with concordant normal results: ≤ 3 years when FFR |
| doi_str_mv | 10.1161/CIRCINTERVENTIONS.113.001049 |
| format | Article |
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We studied 157 intermediate coronary stenoses in 157 patients, evaluated by FFR and CFVR between April 1997 and September 2006 in which revascularization was deferred. Long-term follow-up was performed to document the occurrence of major adverse cardiac events: cardiac death, myocardial infarction, or target vessel revascularization. Discordance between FFR and CFVR occurred in 31% and 37% of stenoses at the 0.75, and 0.80 FFR cut-off value, respectively, and was characterized by microvascular resistances during basal and hyperemic conditions. Follow-up duration amounted to 11.7 years (Q1-Q3, 9.9-13.3 years). Compared with concordant normal results of FFR and CFVR, a normal FFR with an abnormal CFVR was associated with significantly increased major adverse cardiac events rate throughout 10 years of follow-up, regardless of the FFR cut-off applied. In contrast, an abnormal FFR with a normal CFVR was associated with equivalent clinical outcome compared with concordant normal results: ≤ 3 years when FFR <0.75 was depicted abnormal and throughout 10 years of follow-up when FFR ≤ 0.80 was depicted abnormal.
Discordance of CFVR with FFR originates from the involvement of the coronary microvasculature. Importantly, the risk for major adverse cardiac events associated with FFR/CFVR discordance is mainly attributable to stenoses where CFVR is abnormal. This emphasizes the requirement of intracoronary flow assessment in addition to coronary pressure for optimal risk stratification in stable coronary artery disease.</description><identifier>ISSN: 1941-7640</identifier><identifier>EISSN: 1941-7632</identifier><identifier>DOI: 10.1161/CIRCINTERVENTIONS.113.001049</identifier><identifier>PMID: 24782198</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Blood Flow Velocity - physiology ; Coronary Stenosis - epidemiology ; Coronary Stenosis - physiopathology ; Coronary Vessels - physiopathology ; Death, Sudden, Cardiac - epidemiology ; Female ; Follow-Up Studies ; Fractional Flow Reserve, Myocardial - physiology ; Hemodynamics - physiology ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Myocardial Infarction - epidemiology ; Myocardial Revascularization - statistics & numerical data ; Retrospective Studies ; Risk Factors ; Severity of Illness Index</subject><ispartof>Circulation. Cardiovascular interventions, 2014-06, Vol.7 (3), p.301-311</ispartof><rights>2014 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-e666f9aaeb88de25685af11286b57c9eceb76e3afda849ea164cece6f40f543</citedby><cites>FETCH-LOGICAL-c502t-e666f9aaeb88de25685af11286b57c9eceb76e3afda849ea164cece6f40f543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24782198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van de Hoef, Tim P</creatorcontrib><creatorcontrib>van Lavieren, Martijn A</creatorcontrib><creatorcontrib>Damman, Peter</creatorcontrib><creatorcontrib>Delewi, Ronak</creatorcontrib><creatorcontrib>Piek, Martijn A</creatorcontrib><creatorcontrib>Chamuleau, Steven A J</creatorcontrib><creatorcontrib>Voskuil, Michiel</creatorcontrib><creatorcontrib>Henriques, José P S</creatorcontrib><creatorcontrib>Koch, Karel T</creatorcontrib><creatorcontrib>de Winter, Robbert J</creatorcontrib><creatorcontrib>Spaan, Jos A E</creatorcontrib><creatorcontrib>Siebes, Maria</creatorcontrib><creatorcontrib>Tijssen, Jan G P</creatorcontrib><creatorcontrib>Meuwissen, Martijn</creatorcontrib><creatorcontrib>Piek, Jan J</creatorcontrib><title>Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity</title><title>Circulation. Cardiovascular interventions</title><addtitle>Circ Cardiovasc Interv</addtitle><description>Discordance between fractional flow reserve (FFR) and coronary flow velocity reserve (CFVR) may reflect important coronary pathophysiology but usually remains unnoticed in clinical practice. We evaluated the physiological basis and clinical outcome associated with FFR/CFVR discordance.
We studied 157 intermediate coronary stenoses in 157 patients, evaluated by FFR and CFVR between April 1997 and September 2006 in which revascularization was deferred. Long-term follow-up was performed to document the occurrence of major adverse cardiac events: cardiac death, myocardial infarction, or target vessel revascularization. Discordance between FFR and CFVR occurred in 31% and 37% of stenoses at the 0.75, and 0.80 FFR cut-off value, respectively, and was characterized by microvascular resistances during basal and hyperemic conditions. Follow-up duration amounted to 11.7 years (Q1-Q3, 9.9-13.3 years). Compared with concordant normal results of FFR and CFVR, a normal FFR with an abnormal CFVR was associated with significantly increased major adverse cardiac events rate throughout 10 years of follow-up, regardless of the FFR cut-off applied. In contrast, an abnormal FFR with a normal CFVR was associated with equivalent clinical outcome compared with concordant normal results: ≤ 3 years when FFR <0.75 was depicted abnormal and throughout 10 years of follow-up when FFR ≤ 0.80 was depicted abnormal.
Discordance of CFVR with FFR originates from the involvement of the coronary microvasculature. Importantly, the risk for major adverse cardiac events associated with FFR/CFVR discordance is mainly attributable to stenoses where CFVR is abnormal. This emphasizes the requirement of intracoronary flow assessment in addition to coronary pressure for optimal risk stratification in stable coronary artery disease.</description><subject>Aged</subject><subject>Blood Flow Velocity - physiology</subject><subject>Coronary Stenosis - epidemiology</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Coronary Vessels - physiopathology</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fractional Flow Reserve, Myocardial - physiology</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Revascularization - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>1941-7640</issn><issn>1941-7632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUctOAyEUJUbj-xcMCxduRmGGYWYSN6ap2sRUo43bCcNcFENBgbbpb_mFUqt14QpyHvfek4PQKSXnlHJ6MRg9DkbjyfDxeTiejO7HTwkuzgmhhDVbaJ82jGYVL_LtzZ-RPXQQwhshCeb5LtrLWVXntKn30efD6zJoZ9yLlsLgTgQdsLA9Ns6-ZBH8FEuj7TfpZlG6KWCncK-DdL4XVgLuIC4ALFZeyKidTUpl3AJ7CODn8D0tiRPhl2tmDsZJHZcbibZ_ihDBugBhtUbb1QXQaxEBB5iDT64jtKOECXD88x6ip-vhZHCb3d3fjAZXd5ksSR4z4JyrRgjo6rqHvOR1KRSlec27spINSOgqDoVQvahZA4JyJhPIFSOqZMUhOltPfffuYwYhttOUGYwRFtwstLQsGsarhpAkvVxLpXcheFDtu9fTlKWlpF111v7rLMFFu-4s2U9-Ns26lHVj_i2p-ALMJpx5</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>van de Hoef, Tim P</creator><creator>van Lavieren, Martijn A</creator><creator>Damman, Peter</creator><creator>Delewi, Ronak</creator><creator>Piek, Martijn A</creator><creator>Chamuleau, Steven A J</creator><creator>Voskuil, Michiel</creator><creator>Henriques, José P S</creator><creator>Koch, Karel T</creator><creator>de Winter, Robbert J</creator><creator>Spaan, Jos A E</creator><creator>Siebes, Maria</creator><creator>Tijssen, Jan G P</creator><creator>Meuwissen, Martijn</creator><creator>Piek, Jan J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity</title><author>van de Hoef, Tim P ; van Lavieren, Martijn A ; Damman, Peter ; Delewi, Ronak ; Piek, Martijn A ; Chamuleau, Steven A J ; Voskuil, Michiel ; Henriques, José P S ; Koch, Karel T ; de Winter, Robbert J ; Spaan, Jos A E ; Siebes, Maria ; Tijssen, Jan G P ; Meuwissen, Martijn ; Piek, Jan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-e666f9aaeb88de25685af11286b57c9eceb76e3afda849ea164cece6f40f543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Blood Flow Velocity - physiology</topic><topic>Coronary Stenosis - epidemiology</topic><topic>Coronary Stenosis - physiopathology</topic><topic>Coronary Vessels - physiopathology</topic><topic>Death, Sudden, Cardiac - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fractional Flow Reserve, Myocardial - physiology</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Revascularization - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van de Hoef, Tim P</creatorcontrib><creatorcontrib>van Lavieren, Martijn A</creatorcontrib><creatorcontrib>Damman, Peter</creatorcontrib><creatorcontrib>Delewi, Ronak</creatorcontrib><creatorcontrib>Piek, Martijn A</creatorcontrib><creatorcontrib>Chamuleau, Steven A J</creatorcontrib><creatorcontrib>Voskuil, Michiel</creatorcontrib><creatorcontrib>Henriques, José P S</creatorcontrib><creatorcontrib>Koch, Karel T</creatorcontrib><creatorcontrib>de Winter, Robbert J</creatorcontrib><creatorcontrib>Spaan, Jos A E</creatorcontrib><creatorcontrib>Siebes, Maria</creatorcontrib><creatorcontrib>Tijssen, Jan G P</creatorcontrib><creatorcontrib>Meuwissen, Martijn</creatorcontrib><creatorcontrib>Piek, Jan J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation. Cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van de Hoef, Tim P</au><au>van Lavieren, Martijn A</au><au>Damman, Peter</au><au>Delewi, Ronak</au><au>Piek, Martijn A</au><au>Chamuleau, Steven A J</au><au>Voskuil, Michiel</au><au>Henriques, José P S</au><au>Koch, Karel T</au><au>de Winter, Robbert J</au><au>Spaan, Jos A E</au><au>Siebes, Maria</au><au>Tijssen, Jan G P</au><au>Meuwissen, Martijn</au><au>Piek, Jan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity</atitle><jtitle>Circulation. Cardiovascular interventions</jtitle><addtitle>Circ Cardiovasc Interv</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>7</volume><issue>3</issue><spage>301</spage><epage>311</epage><pages>301-311</pages><issn>1941-7640</issn><eissn>1941-7632</eissn><abstract>Discordance between fractional flow reserve (FFR) and coronary flow velocity reserve (CFVR) may reflect important coronary pathophysiology but usually remains unnoticed in clinical practice. We evaluated the physiological basis and clinical outcome associated with FFR/CFVR discordance.
We studied 157 intermediate coronary stenoses in 157 patients, evaluated by FFR and CFVR between April 1997 and September 2006 in which revascularization was deferred. Long-term follow-up was performed to document the occurrence of major adverse cardiac events: cardiac death, myocardial infarction, or target vessel revascularization. Discordance between FFR and CFVR occurred in 31% and 37% of stenoses at the 0.75, and 0.80 FFR cut-off value, respectively, and was characterized by microvascular resistances during basal and hyperemic conditions. Follow-up duration amounted to 11.7 years (Q1-Q3, 9.9-13.3 years). Compared with concordant normal results of FFR and CFVR, a normal FFR with an abnormal CFVR was associated with significantly increased major adverse cardiac events rate throughout 10 years of follow-up, regardless of the FFR cut-off applied. In contrast, an abnormal FFR with a normal CFVR was associated with equivalent clinical outcome compared with concordant normal results: ≤ 3 years when FFR <0.75 was depicted abnormal and throughout 10 years of follow-up when FFR ≤ 0.80 was depicted abnormal.
Discordance of CFVR with FFR originates from the involvement of the coronary microvasculature. Importantly, the risk for major adverse cardiac events associated with FFR/CFVR discordance is mainly attributable to stenoses where CFVR is abnormal. This emphasizes the requirement of intracoronary flow assessment in addition to coronary pressure for optimal risk stratification in stable coronary artery disease.</abstract><cop>United States</cop><pmid>24782198</pmid><doi>10.1161/CIRCINTERVENTIONS.113.001049</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Blood Flow Velocity - physiology Coronary Stenosis - epidemiology Coronary Stenosis - physiopathology Coronary Vessels - physiopathology Death, Sudden, Cardiac - epidemiology Female Follow-Up Studies Fractional Flow Reserve, Myocardial - physiology Hemodynamics - physiology Humans Incidence Longitudinal Studies Male Middle Aged Myocardial Infarction - epidemiology Myocardial Revascularization - statistics & numerical data Retrospective Studies Risk Factors Severity of Illness Index |
| title | Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity |
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