Clinicopathological roles of S100A8 and S100A9 in cutaneous squamous cell carcinoma in vivo and in vitro
S100A8 and S100A9 are members of the S100 protein family and exist in neutrophils, monocytes, and macrophages. Recent studies have shown that S100A8 and S100A9 are associated with various neoplastic disorders; however, their roles in cutaneous squamous cell carcinoma (SCC) are not well defined. To i...
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| Veröffentlicht in: | Archives of Dermatological Research 2014-07, Vol.306 (5), p.489-496 |
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| creator | Choi, Dae-Kyoung Li, Zheng Jun Chang, In-Kyu Yeo, Min-Kyung Kim, Jin-Man Sohn, Kyung-Cheol Im, Myung Seo, Young-Joon Lee, Jeung-Hoon Kim, Chang-Deok Lee, Young |
| description | S100A8 and S100A9 are members of the S100 protein family and exist in neutrophils, monocytes, and macrophages. Recent studies have shown that S100A8 and S100A9 are associated with various neoplastic disorders; however, their roles in cutaneous squamous cell carcinoma (SCC) are not well defined. To investigate the expression and function of S100A8 and S100A9 in skin tumors, we examined the expression levels of S100A8 and S100A9 between premalignant and malignant skin tumors and investigated the functional roles of S100A8 and S100A9 in vitro and in vivo using recombinant adenovirus expressing S100A8 or S100A9. The immunopositive staining rates and intensities of S100A8 and S100A9 were higher in SCC than in premalignant skin tumors. When S100A8 and/or S100A9 were overexpressed in SCC12 cells using a recombinant adenovirus, cell growth and motility were increased. Similarly, when mouse skin was intradermally injected with SCC12 cells overexpressing S100A8 and/or S100A9, there were remarkable increases in tumor growth and volume. Both S100A8 and S100A9 are highly expressed in cutaneous SCC and play important roles in tumorigenesis. We suggest that S100A8 and S100A9 may be potential therapeutic targets for the prevention or treatment of SCC in skin. |
| doi_str_mv | 10.1007/s00403-014-1453-y |
| format | Article |
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Recent studies have shown that S100A8 and S100A9 are associated with various neoplastic disorders; however, their roles in cutaneous squamous cell carcinoma (SCC) are not well defined. To investigate the expression and function of S100A8 and S100A9 in skin tumors, we examined the expression levels of S100A8 and S100A9 between premalignant and malignant skin tumors and investigated the functional roles of S100A8 and S100A9 in vitro and in vivo using recombinant adenovirus expressing S100A8 or S100A9. The immunopositive staining rates and intensities of S100A8 and S100A9 were higher in SCC than in premalignant skin tumors. When S100A8 and/or S100A9 were overexpressed in SCC12 cells using a recombinant adenovirus, cell growth and motility were increased. Similarly, when mouse skin was intradermally injected with SCC12 cells overexpressing S100A8 and/or S100A9, there were remarkable increases in tumor growth and volume. Both S100A8 and S100A9 are highly expressed in cutaneous SCC and play important roles in tumorigenesis. We suggest that S100A8 and S100A9 may be potential therapeutic targets for the prevention or treatment of SCC in skin.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-014-1453-y</identifier><identifier>PMID: 24550082</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoviridae - genetics ; Animals ; Calgranulin A - biosynthesis ; Calgranulin A - genetics ; Calgranulin B - biosynthesis ; Calgranulin B - genetics ; Carcinoma, Squamous Cell - pathology ; Cell Line, Tumor ; Cell Proliferation ; Dermatology ; Gene Expression ; Humans ; Medicine ; Medicine & Public Health ; Mice ; Mice, SCID ; Neoplasm Transplantation ; Original Paper ; Skin Neoplasms - pathology ; Transplantation, Heterologous ; Ultraviolet Rays - adverse effects</subject><ispartof>Archives of Dermatological Research, 2014-07, Vol.306 (5), p.489-496</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-3120751c310d365955792b367edfc5ff60197ce1218f576d809f4874cbf18f4b3</citedby><cites>FETCH-LOGICAL-c508t-3120751c310d365955792b367edfc5ff60197ce1218f576d809f4874cbf18f4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-014-1453-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-014-1453-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24550082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Dae-Kyoung</creatorcontrib><creatorcontrib>Li, Zheng Jun</creatorcontrib><creatorcontrib>Chang, In-Kyu</creatorcontrib><creatorcontrib>Yeo, Min-Kyung</creatorcontrib><creatorcontrib>Kim, Jin-Man</creatorcontrib><creatorcontrib>Sohn, Kyung-Cheol</creatorcontrib><creatorcontrib>Im, Myung</creatorcontrib><creatorcontrib>Seo, Young-Joon</creatorcontrib><creatorcontrib>Lee, Jeung-Hoon</creatorcontrib><creatorcontrib>Kim, Chang-Deok</creatorcontrib><creatorcontrib>Lee, Young</creatorcontrib><title>Clinicopathological roles of S100A8 and S100A9 in cutaneous squamous cell carcinoma in vivo and in vitro</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>S100A8 and S100A9 are members of the S100 protein family and exist in neutrophils, monocytes, and macrophages. Recent studies have shown that S100A8 and S100A9 are associated with various neoplastic disorders; however, their roles in cutaneous squamous cell carcinoma (SCC) are not well defined. To investigate the expression and function of S100A8 and S100A9 in skin tumors, we examined the expression levels of S100A8 and S100A9 between premalignant and malignant skin tumors and investigated the functional roles of S100A8 and S100A9 in vitro and in vivo using recombinant adenovirus expressing S100A8 or S100A9. The immunopositive staining rates and intensities of S100A8 and S100A9 were higher in SCC than in premalignant skin tumors. When S100A8 and/or S100A9 were overexpressed in SCC12 cells using a recombinant adenovirus, cell growth and motility were increased. Similarly, when mouse skin was intradermally injected with SCC12 cells overexpressing S100A8 and/or S100A9, there were remarkable increases in tumor growth and volume. Both S100A8 and S100A9 are highly expressed in cutaneous SCC and play important roles in tumorigenesis. We suggest that S100A8 and S100A9 may be potential therapeutic targets for the prevention or treatment of SCC in skin.</description><subject>Adenoviridae - genetics</subject><subject>Animals</subject><subject>Calgranulin A - biosynthesis</subject><subject>Calgranulin A - genetics</subject><subject>Calgranulin B - biosynthesis</subject><subject>Calgranulin B - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Dermatology</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Neoplasm Transplantation</subject><subject>Original Paper</subject><subject>Skin Neoplasms - pathology</subject><subject>Transplantation, Heterologous</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kV1L5DAUhsPisg6z8wP2RgreeFM9p_lqL2XwCwQv3IW9C5k00UrbjEkrzL83naqIYG5yOHnOe17yEvIH4RQB5FkEYEBzQJYj4zTf_SALZLTIQVT_D8gCKIOcikocklWMT5COBFaA_EUOC8Y5QFksyOO6bfrG-K0eHn3rHxqj2yz41sbMu-w-bTovM93Xc1llTZ-ZcdC99WPM4vOou6kwtm0zo4Npet_pCXppXvx-bl8Pwf8mP51uo1293Uvy7_Li7_o6v727ulmf3-aGQznkFJNDjoYi1FTwinNZFRsqpK2d4c4JwEoaiwWWjktRl1A5VkpmNi512IYuycmsuw3-ebRxUF0TJ3-zZ4WcVkzIEjGhx1_QJz-GPrmbKIlclGyicKZM8DEG69Q2NJ0OO4WgpiTUnIRKSagpCbVLM0dvyuOms_XHxPu_J6CYgZie-gcbPq3-VvUVSAaQ8w</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Choi, Dae-Kyoung</creator><creator>Li, Zheng Jun</creator><creator>Chang, In-Kyu</creator><creator>Yeo, Min-Kyung</creator><creator>Kim, Jin-Man</creator><creator>Sohn, Kyung-Cheol</creator><creator>Im, Myung</creator><creator>Seo, Young-Joon</creator><creator>Lee, Jeung-Hoon</creator><creator>Kim, Chang-Deok</creator><creator>Lee, Young</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Clinicopathological roles of S100A8 and S100A9 in cutaneous squamous cell carcinoma in vivo and in vitro</title><author>Choi, Dae-Kyoung ; Li, Zheng Jun ; Chang, In-Kyu ; Yeo, Min-Kyung ; Kim, Jin-Man ; Sohn, Kyung-Cheol ; Im, Myung ; Seo, Young-Joon ; Lee, Jeung-Hoon ; Kim, Chang-Deok ; Lee, Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-3120751c310d365955792b367edfc5ff60197ce1218f576d809f4874cbf18f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenoviridae - genetics</topic><topic>Animals</topic><topic>Calgranulin A - biosynthesis</topic><topic>Calgranulin A - genetics</topic><topic>Calgranulin B - biosynthesis</topic><topic>Calgranulin B - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Dermatology</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Neoplasm Transplantation</topic><topic>Original Paper</topic><topic>Skin Neoplasms - pathology</topic><topic>Transplantation, Heterologous</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Dae-Kyoung</creatorcontrib><creatorcontrib>Li, Zheng Jun</creatorcontrib><creatorcontrib>Chang, In-Kyu</creatorcontrib><creatorcontrib>Yeo, Min-Kyung</creatorcontrib><creatorcontrib>Kim, Jin-Man</creatorcontrib><creatorcontrib>Sohn, Kyung-Cheol</creatorcontrib><creatorcontrib>Im, Myung</creatorcontrib><creatorcontrib>Seo, Young-Joon</creatorcontrib><creatorcontrib>Lee, Jeung-Hoon</creatorcontrib><creatorcontrib>Kim, Chang-Deok</creatorcontrib><creatorcontrib>Lee, Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Dae-Kyoung</au><au>Li, Zheng Jun</au><au>Chang, In-Kyu</au><au>Yeo, Min-Kyung</au><au>Kim, Jin-Man</au><au>Sohn, Kyung-Cheol</au><au>Im, Myung</au><au>Seo, Young-Joon</au><au>Lee, Jeung-Hoon</au><au>Kim, Chang-Deok</au><au>Lee, Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological roles of S100A8 and S100A9 in cutaneous squamous cell carcinoma in vivo and in vitro</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>306</volume><issue>5</issue><spage>489</spage><epage>496</epage><pages>489-496</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>S100A8 and S100A9 are members of the S100 protein family and exist in neutrophils, monocytes, and macrophages. Recent studies have shown that S100A8 and S100A9 are associated with various neoplastic disorders; however, their roles in cutaneous squamous cell carcinoma (SCC) are not well defined. To investigate the expression and function of S100A8 and S100A9 in skin tumors, we examined the expression levels of S100A8 and S100A9 between premalignant and malignant skin tumors and investigated the functional roles of S100A8 and S100A9 in vitro and in vivo using recombinant adenovirus expressing S100A8 or S100A9. The immunopositive staining rates and intensities of S100A8 and S100A9 were higher in SCC than in premalignant skin tumors. When S100A8 and/or S100A9 were overexpressed in SCC12 cells using a recombinant adenovirus, cell growth and motility were increased. Similarly, when mouse skin was intradermally injected with SCC12 cells overexpressing S100A8 and/or S100A9, there were remarkable increases in tumor growth and volume. Both S100A8 and S100A9 are highly expressed in cutaneous SCC and play important roles in tumorigenesis. We suggest that S100A8 and S100A9 may be potential therapeutic targets for the prevention or treatment of SCC in skin.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24550082</pmid><doi>10.1007/s00403-014-1453-y</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenoviridae - genetics Animals Calgranulin A - biosynthesis Calgranulin A - genetics Calgranulin B - biosynthesis Calgranulin B - genetics Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Proliferation Dermatology Gene Expression Humans Medicine Medicine & Public Health Mice Mice, SCID Neoplasm Transplantation Original Paper Skin Neoplasms - pathology Transplantation, Heterologous Ultraviolet Rays - adverse effects |
| title | Clinicopathological roles of S100A8 and S100A9 in cutaneous squamous cell carcinoma in vivo and in vitro |
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