Anaphylaxis as a Clinical Manifestation of Clonal Mast Cell Disorders
Clonal mast cell disorders comprise a heterogeneous group of disorders characterized by the presence of gain of function KIT mutations and a constitutively altered activation-associated mast cell immunophenotype frequently associated with clinical manifestations related to the release of mast cells...
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| Veröffentlicht in: | Current allergy and asthma reports 2014-08, Vol.14 (8), p.450-450, Article 450 |
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| container_title | Current allergy and asthma reports |
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| creator | Matito, A. Alvarez-Twose, I. Morgado, J. M. Sánchez-Muñoz, L. Orfao, A. Escribano, L. |
| description | Clonal mast cell disorders comprise a heterogeneous group of disorders characterized by the presence of gain of function
KIT
mutations and a constitutively altered activation-associated mast cell immunophenotype frequently associated with clinical manifestations related to the release of mast cells mediators. These disorders do not always fulfil the World Health Organization (WHO)-proposed criteria for mastocytosis, particularly when low-sensitive diagnostic approaches are performed. Anaphylaxis is a frequent presentation of clonal mast cell disorders, particularly in mastocytosis patients without typical skin lesions. The presence of cardiovascular symptoms, e.g., hypotension, occurring after a hymenoptera sting or spontaneously in the absence of cutaneous manifestations such as urticaria is characteristic and differs from the presentation of anaphylaxis in the general population without mastocytosis. |
| doi_str_mv | 10.1007/s11882-014-0450-8 |
| format | Article |
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KIT
mutations and a constitutively altered activation-associated mast cell immunophenotype frequently associated with clinical manifestations related to the release of mast cells mediators. These disorders do not always fulfil the World Health Organization (WHO)-proposed criteria for mastocytosis, particularly when low-sensitive diagnostic approaches are performed. Anaphylaxis is a frequent presentation of clonal mast cell disorders, particularly in mastocytosis patients without typical skin lesions. The presence of cardiovascular symptoms, e.g., hypotension, occurring after a hymenoptera sting or spontaneously in the absence of cutaneous manifestations such as urticaria is characteristic and differs from the presentation of anaphylaxis in the general population without mastocytosis.</description><identifier>ISSN: 1529-7322</identifier><identifier>EISSN: 1534-6315</identifier><identifier>DOI: 10.1007/s11882-014-0450-8</identifier><identifier>PMID: 24947681</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Allergology ; Anaphylaxis - genetics ; Anaphylaxis - immunology ; Anaphylaxis - therapy ; Anaphylaxis and Drug Allergy (Da Khan and M Castells ; Humans ; Mast Cells - immunology ; Mast Cells - pathology ; Mastocytosis - complications ; Mastocytosis - immunology ; Medicine ; Medicine & Public Health ; Section Editors ; Topical Collection on Anaphylaxis and Drug Allergy ; Treatment Outcome</subject><ispartof>Current allergy and asthma reports, 2014-08, Vol.14 (8), p.450-450, Article 450</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-9892b3dc52e666dab849953facab3364c916a79499f35b76ddc0850fdeecf81f3</citedby><cites>FETCH-LOGICAL-c442t-9892b3dc52e666dab849953facab3364c916a79499f35b76ddc0850fdeecf81f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11882-014-0450-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11882-014-0450-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24947681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matito, A.</creatorcontrib><creatorcontrib>Alvarez-Twose, I.</creatorcontrib><creatorcontrib>Morgado, J. M.</creatorcontrib><creatorcontrib>Sánchez-Muñoz, L.</creatorcontrib><creatorcontrib>Orfao, A.</creatorcontrib><creatorcontrib>Escribano, L.</creatorcontrib><title>Anaphylaxis as a Clinical Manifestation of Clonal Mast Cell Disorders</title><title>Current allergy and asthma reports</title><addtitle>Curr Allergy Asthma Rep</addtitle><addtitle>Curr Allergy Asthma Rep</addtitle><description>Clonal mast cell disorders comprise a heterogeneous group of disorders characterized by the presence of gain of function
KIT
mutations and a constitutively altered activation-associated mast cell immunophenotype frequently associated with clinical manifestations related to the release of mast cells mediators. These disorders do not always fulfil the World Health Organization (WHO)-proposed criteria for mastocytosis, particularly when low-sensitive diagnostic approaches are performed. Anaphylaxis is a frequent presentation of clonal mast cell disorders, particularly in mastocytosis patients without typical skin lesions. The presence of cardiovascular symptoms, e.g., hypotension, occurring after a hymenoptera sting or spontaneously in the absence of cutaneous manifestations such as urticaria is characteristic and differs from the presentation of anaphylaxis in the general population without mastocytosis.</description><subject>Allergology</subject><subject>Anaphylaxis - genetics</subject><subject>Anaphylaxis - immunology</subject><subject>Anaphylaxis - therapy</subject><subject>Anaphylaxis and Drug Allergy (Da Khan and M Castells</subject><subject>Humans</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - pathology</subject><subject>Mastocytosis - complications</subject><subject>Mastocytosis - immunology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Section Editors</subject><subject>Topical Collection on Anaphylaxis and Drug Allergy</subject><subject>Treatment Outcome</subject><issn>1529-7322</issn><issn>1534-6315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtLxDAUhYMozjj6A9xIwY2baF5Nk-Uwjg9Q3Og6pGmiGTrtmLTg_HtTO4oIQiDh3u-ee3IAOMXoEiNUXEWMhSAQYQYRyxEUe2CKc8ogpzjfH95EwoISMgFHMa4QImmKHIIJYZIVXOApWM4bvXnb1vrDx0ynky1q33ij6-xRN97Z2OnOt03WutRpm6967LKFrevs2sc2VDbEY3DgdB3tye6egZeb5fPiDj483d4v5g_QMEY6KIUkJa1MTiznvNKlYFLm1GmjS0o5MxJzXchUdDQvC15VBokcucpa4wR2dAYuRt1NaN_75E2tfTTJim5s20eVPi8Z55KjhJ7_QVdtH5L_gWIDgXOZKDxSJrQxBuvUJvi1DluFkRoyVmPGKmWshoyVSDNnO-W-XNvqZ-I71ASQEYip1bza8Gv1v6qfEfqFUA</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Matito, A.</creator><creator>Alvarez-Twose, I.</creator><creator>Morgado, J. 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KIT
mutations and a constitutively altered activation-associated mast cell immunophenotype frequently associated with clinical manifestations related to the release of mast cells mediators. These disorders do not always fulfil the World Health Organization (WHO)-proposed criteria for mastocytosis, particularly when low-sensitive diagnostic approaches are performed. Anaphylaxis is a frequent presentation of clonal mast cell disorders, particularly in mastocytosis patients without typical skin lesions. The presence of cardiovascular symptoms, e.g., hypotension, occurring after a hymenoptera sting or spontaneously in the absence of cutaneous manifestations such as urticaria is characteristic and differs from the presentation of anaphylaxis in the general population without mastocytosis.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24947681</pmid><doi>10.1007/s11882-014-0450-8</doi><tpages>1</tpages></addata></record> |
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| subjects | Allergology Anaphylaxis - genetics Anaphylaxis - immunology Anaphylaxis - therapy Anaphylaxis and Drug Allergy (Da Khan and M Castells Humans Mast Cells - immunology Mast Cells - pathology Mastocytosis - complications Mastocytosis - immunology Medicine Medicine & Public Health Section Editors Topical Collection on Anaphylaxis and Drug Allergy Treatment Outcome |
| title | Anaphylaxis as a Clinical Manifestation of Clonal Mast Cell Disorders |
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