Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury

It is well-established that exercise diminishes cardiovascular risk, but whether humoral factors secreted by muscle confer these benefits has not been conclusively shown. We have shown that the secreted protein follistatin-like 1 (Fstl1) has beneficial actions on cardiac and endothelial function. Ho...

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Veröffentlicht in:	Cardiovascular research 2014-07, Vol.103 (1), p.111-120
Hauptverfasser:	Miyabe, Megumi, Ohashi, Koji, Shibata, Rei, Uemura, Yusuke, Ogura, Yasuhiro, Yuasa, Daisuke, Kambara, Takahiro, Kataoka, Yoshiyuki, Yamamoto, Takashi, Matsuo, Kazuhiro, Joki, Yusuke, Enomoto, Takashi, Hayakawa, Satoko, Hiramatsu-Ito, Mizuho, Ito, Masanori, Van Den Hoff, Maurice J B, Walsh, Kenneth, Murohara, Toyoaki, Ouchi, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism Animals Cell Movement Cell Proliferation Cells, Cultured Disease Models, Animal Femoral Artery - injuries Femoral Artery - pathology Femoral Artery - physiopathology Follistatin-Related Proteins - antagonists & inhibitors Follistatin-Related Proteins - genetics Follistatin-Related Proteins - physiology Gene Knockdown Techniques Humans Mice Mice, Inbred C57BL Mice, Transgenic Muscle, Skeletal - physiology Myocytes, Smooth Muscle - pathology Myocytes, Smooth Muscle - physiology Neointima - pathology Neointima - physiopathology Neointima - prevention & control Proto-Oncogene Proteins c-sis - metabolism
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