Clathrin-mediated endocytosis is inhibited during mitosis

A long-standing paradigm in cell biology is the shutdown of endocytosis during mitosis. There is consensus that transferrin uptake is inhibited after entry into prophase and that it resumes in telophase. A recent study proposed that endocytosis is continuous throughout the cell cycle and that the ob...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (17), p.6572-6577
Hauptverfasser:	Fielding, Andrew B, Willox, Anna K, Okeke, Emmanuel, Royle, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological Sciences Cell cycle Cell division Cell membranes chimerism Clathrin Clathrin - physiology Cytoplasm Endocytosis Endocytosis - physiology Flow Cytometry Fluorescent Antibody Technique HeLa Cells Humans Internalization Interphase mannose metabolism Microscopy, Fluorescence Mitosis Mitosis - physiology physiology prophase Proteins Receptors Receptors, Transferrin Receptors, Transferrin - metabolism telophase transferrin Transferrins
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