Antitumorigenic potential of STAT3 alternative splicing modulation

Signal transducer and activator of transcription 3 (STAT3) plays a central role in the activation of multiple oncogenic pathways. Splicing variant STAT3β uses an alternative acceptor site within exon 23 that leads to a truncated isoform lacking the C-terminal transactivation domain. Depending on the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (43), p.17779-17784
Hauptverfasser:	Zammarchi, Francesca, de Stanchina, Elisa, Bournazou, Eirini, Supakorndej, Teerawit, Martires, Kathryn, Riedel, Elyn, Corben, Adriana D., Bromberg, Jacqueline F., Cartegni, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative splicing Alternative Splicing - genetics Animals Apoptosis Biological Sciences Blotting, Western Cancer Cell cycle Cell death Cell Line Cell lines Cells DNA Primers - genetics Down regulation Enzyme-Linked Immunosorbent Assay Exons Flow Cytometry Gene Expression Regulation, Neoplastic - genetics Genes Humans Immunohistochemistry In Situ Nick-End Labeling Mice Mice, Nude Microarray Analysis Neoplasms - genetics oligonucleotides Oligonucleotides, Antisense - genetics Phosphorylation Protein isoforms Protein Isoforms - genetics Protein Isoforms - metabolism remission Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - genetics Signal transduction Splicing STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism transcriptional activation Tumors tyrosine Viability
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