Tat trans-activates the human immunodeficiency virus through a nascent RNA target

Expression of the human immunodeficiency virus type 1 (HIV-1) genome is greatly dependent on the viral trans-activator protein Tat. Tat functions through the TAR element, which is represented in both viral DNA and RNA. At present, there is no definitive evidence that determines whether Tat acts thro...

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Veröffentlicht in:	Cell 1989-10, Vol.59 (2), p.273-282
Hauptverfasser:	Berkhout, Ben, Silverman, Robert H., Jeang, Kuan-Teh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell Line Enhancer Elements, Genetic Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Regulation, Viral Gene Products, tat - metabolism Genes, Viral HIV-1 - genetics HIV-1 - growth & development Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation Plasmids RNA - genetics RNA, Antisense RNA, Messenger - antagonists & inhibitors RNA, Messenger - genetics RNA, Viral - genetics tat Gene Products, Human Immunodeficiency Virus Trans-Activators - metabolism Transcription, Genetic Viral Structural Proteins - genetics Virus Activation
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