On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies
Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic...
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Veröffentlicht in: | Brain research 1989-10, Vol.500 (1), p.302-312 |
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creator | Faingold, Carl L. Gehlbach, Greta Caspary, Donald M. |
description | Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic application onto IC neurons of agents affecting the action of γ-aminobutyric acid (GABA). The agents examined include GABA, a GABA
B agonist (baclofen), a GABA
A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA
A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus. |
doi_str_mv | 10.1016/0006-8993(89)90326-0 |
format | Article |
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B agonist (baclofen), a GABA
A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA
A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(89)90326-0</identifier><identifier>PMID: 2605499</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Action Potentials - drug effects ; Animals ; Auditory Pathways - drug effects ; Auditory Pathways - physiology ; Benzodiazepine ; Bicuculline ; Bicuculline - pharmacology ; Binaural inhibition ; gamma-Aminobutyric Acid - physiology ; Glycine ; Inferior Colliculi - drug effects ; Inferior Colliculi - physiology ; Inferior colliculus ; Neural Inhibition - drug effects ; Nipecotic acid ; Rats ; Rats, Inbred Strains ; Strychnine ; Strychnine - pharmacology ; γ-Aminobutyric acid</subject><ispartof>Brain research, 1989-10, Vol.500 (1), p.302-312</ispartof><rights>1989 Elsevier Science Publishers B.V. (Biomedical Division)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-527f8ae7f4782d433ec9dca0d691700c6b56672725720f2992878c871dde5b6b3</citedby><cites>FETCH-LOGICAL-c454t-527f8ae7f4782d433ec9dca0d691700c6b56672725720f2992878c871dde5b6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(89)90326-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2605499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faingold, Carl L.</creatorcontrib><creatorcontrib>Gehlbach, Greta</creatorcontrib><creatorcontrib>Caspary, Donald M.</creatorcontrib><title>On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic application onto IC neurons of agents affecting the action of γ-aminobutyric acid (GABA). The agents examined include GABA, a GABA
B agonist (baclofen), a GABA
A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA
A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus.</description><subject>Acoustic Stimulation</subject><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Auditory Pathways - drug effects</subject><subject>Auditory Pathways - physiology</subject><subject>Benzodiazepine</subject><subject>Bicuculline</subject><subject>Bicuculline - pharmacology</subject><subject>Binaural inhibition</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Glycine</subject><subject>Inferior Colliculi - drug effects</subject><subject>Inferior Colliculi - physiology</subject><subject>Inferior colliculus</subject><subject>Neural Inhibition - drug effects</subject><subject>Nipecotic acid</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Strychnine</subject><subject>Strychnine - pharmacology</subject><subject>γ-Aminobutyric acid</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMouq5-A4WcRA_VNG2TxoOwLv4DwYueQ5tM2Wg3WZNU2G9v1i57FIYZwntvhvwQOsvJdU5ydkMIYVktRHFZiytBCsoysocmec1pxmhJ9tFkZzlCxyF8pmdRCHKIDikjVSnEBH29WRwXgL3rAbsOP83uZ7gJuLHY2IVpTXR-jS0M3kXf2LA0MYJPWqoOvHEeK9f3Rg39EEafDbfYOBvdauE8RKNwiIM2EE7QQdf0AU63c4o-Hh_e58_Z69vTy3z2mqmyKmNWUd7VDfCu5DXVZVGAElo1RDORc0IUayvGOOW04pR0VAha81rVPNcaqpa1xRRdjHtX3n0PEKJcmqCg7xsLbggyr4qUSH2KytGovAvBQydX3iwbv5Y5kRvGcgNQbgCmJv8YS5Ji59v9Q7sEvQttoSb9btQhffLHgJdBGbAKtPGgotTO_H_gF9JQjAs</recordid><startdate>19891023</startdate><enddate>19891023</enddate><creator>Faingold, Carl L.</creator><creator>Gehlbach, Greta</creator><creator>Caspary, Donald M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19891023</creationdate><title>On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies</title><author>Faingold, Carl L. ; Gehlbach, Greta ; Caspary, Donald M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-527f8ae7f4782d433ec9dca0d691700c6b56672725720f2992878c871dde5b6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acoustic Stimulation</topic><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Auditory Pathways - drug effects</topic><topic>Auditory Pathways - physiology</topic><topic>Benzodiazepine</topic><topic>Bicuculline</topic><topic>Bicuculline - pharmacology</topic><topic>Binaural inhibition</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Glycine</topic><topic>Inferior Colliculi - drug effects</topic><topic>Inferior Colliculi - physiology</topic><topic>Inferior colliculus</topic><topic>Neural Inhibition - drug effects</topic><topic>Nipecotic acid</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Strychnine</topic><topic>Strychnine - pharmacology</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faingold, Carl L.</creatorcontrib><creatorcontrib>Gehlbach, Greta</creatorcontrib><creatorcontrib>Caspary, Donald M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faingold, Carl L.</au><au>Gehlbach, Greta</au><au>Caspary, Donald M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1989-10-23</date><risdate>1989</risdate><volume>500</volume><issue>1</issue><spage>302</spage><epage>312</epage><pages>302-312</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic application onto IC neurons of agents affecting the action of γ-aminobutyric acid (GABA). The agents examined include GABA, a GABA
B agonist (baclofen), a GABA
A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA
A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2605499</pmid><doi>10.1016/0006-8993(89)90326-0</doi><tpages>11</tpages></addata></record> |
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subjects | Acoustic Stimulation Action Potentials - drug effects Animals Auditory Pathways - drug effects Auditory Pathways - physiology Benzodiazepine Bicuculline Bicuculline - pharmacology Binaural inhibition gamma-Aminobutyric Acid - physiology Glycine Inferior Colliculi - drug effects Inferior Colliculi - physiology Inferior colliculus Neural Inhibition - drug effects Nipecotic acid Rats Rats, Inbred Strains Strychnine Strychnine - pharmacology γ-Aminobutyric acid |
title | On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies |
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