On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies

Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Brain research 1989-10, Vol.500 (1), p.302-312
Hauptverfasser: Faingold, Carl L., Gehlbach, Greta, Caspary, Donald M.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 312
container_issue 1
container_start_page 302
container_title Brain research
container_volume 500
creator Faingold, Carl L.
Gehlbach, Greta
Caspary, Donald M.
description Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic application onto IC neurons of agents affecting the action of γ-aminobutyric acid (GABA). The agents examined include GABA, a GABA B agonist (baclofen), a GABA A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus.
doi_str_mv 10.1016/0006-8993(89)90326-0
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15387815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006899389903260</els_id><sourcerecordid>15387815</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-527f8ae7f4782d433ec9dca0d691700c6b56672725720f2992878c871dde5b6b3</originalsourceid><addsrcrecordid>eNp9kE9LxDAQxYMouq5-A4WcRA_VNG2TxoOwLv4DwYueQ5tM2Wg3WZNU2G9v1i57FIYZwntvhvwQOsvJdU5ydkMIYVktRHFZiytBCsoysocmec1pxmhJ9tFkZzlCxyF8pmdRCHKIDikjVSnEBH29WRwXgL3rAbsOP83uZ7gJuLHY2IVpTXR-jS0M3kXf2LA0MYJPWqoOvHEeK9f3Rg39EEafDbfYOBvdauE8RKNwiIM2EE7QQdf0AU63c4o-Hh_e58_Z69vTy3z2mqmyKmNWUd7VDfCu5DXVZVGAElo1RDORc0IUayvGOOW04pR0VAha81rVPNcaqpa1xRRdjHtX3n0PEKJcmqCg7xsLbggyr4qUSH2KytGovAvBQydX3iwbv5Y5kRvGcgNQbgCmJv8YS5Ji59v9Q7sEvQttoSb9btQhffLHgJdBGbAKtPGgotTO_H_gF9JQjAs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15387815</pqid></control><display><type>article</type><title>On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Faingold, Carl L. ; Gehlbach, Greta ; Caspary, Donald M.</creator><creatorcontrib>Faingold, Carl L. ; Gehlbach, Greta ; Caspary, Donald M.</creatorcontrib><description>Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic application onto IC neurons of agents affecting the action of γ-aminobutyric acid (GABA). The agents examined include GABA, a GABA B agonist (baclofen), a GABA A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(89)90326-0</identifier><identifier>PMID: 2605499</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Action Potentials - drug effects ; Animals ; Auditory Pathways - drug effects ; Auditory Pathways - physiology ; Benzodiazepine ; Bicuculline ; Bicuculline - pharmacology ; Binaural inhibition ; gamma-Aminobutyric Acid - physiology ; Glycine ; Inferior Colliculi - drug effects ; Inferior Colliculi - physiology ; Inferior colliculus ; Neural Inhibition - drug effects ; Nipecotic acid ; Rats ; Rats, Inbred Strains ; Strychnine ; Strychnine - pharmacology ; γ-Aminobutyric acid</subject><ispartof>Brain research, 1989-10, Vol.500 (1), p.302-312</ispartof><rights>1989 Elsevier Science Publishers B.V. (Biomedical Division)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-527f8ae7f4782d433ec9dca0d691700c6b56672725720f2992878c871dde5b6b3</citedby><cites>FETCH-LOGICAL-c454t-527f8ae7f4782d433ec9dca0d691700c6b56672725720f2992878c871dde5b6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(89)90326-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2605499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faingold, Carl L.</creatorcontrib><creatorcontrib>Gehlbach, Greta</creatorcontrib><creatorcontrib>Caspary, Donald M.</creatorcontrib><title>On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic application onto IC neurons of agents affecting the action of γ-aminobutyric acid (GABA). The agents examined include GABA, a GABA B agonist (baclofen), a GABA A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus.</description><subject>Acoustic Stimulation</subject><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Auditory Pathways - drug effects</subject><subject>Auditory Pathways - physiology</subject><subject>Benzodiazepine</subject><subject>Bicuculline</subject><subject>Bicuculline - pharmacology</subject><subject>Binaural inhibition</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Glycine</subject><subject>Inferior Colliculi - drug effects</subject><subject>Inferior Colliculi - physiology</subject><subject>Inferior colliculus</subject><subject>Neural Inhibition - drug effects</subject><subject>Nipecotic acid</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Strychnine</subject><subject>Strychnine - pharmacology</subject><subject>γ-Aminobutyric acid</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMouq5-A4WcRA_VNG2TxoOwLv4DwYueQ5tM2Wg3WZNU2G9v1i57FIYZwntvhvwQOsvJdU5ydkMIYVktRHFZiytBCsoysocmec1pxmhJ9tFkZzlCxyF8pmdRCHKIDikjVSnEBH29WRwXgL3rAbsOP83uZ7gJuLHY2IVpTXR-jS0M3kXf2LA0MYJPWqoOvHEeK9f3Rg39EEafDbfYOBvdauE8RKNwiIM2EE7QQdf0AU63c4o-Hh_e58_Z69vTy3z2mqmyKmNWUd7VDfCu5DXVZVGAElo1RDORc0IUayvGOOW04pR0VAha81rVPNcaqpa1xRRdjHtX3n0PEKJcmqCg7xsLbggyr4qUSH2KytGovAvBQydX3iwbv5Y5kRvGcgNQbgCmJv8YS5Ji59v9Q7sEvQttoSb9btQhffLHgJdBGbAKtPGgotTO_H_gF9JQjAs</recordid><startdate>19891023</startdate><enddate>19891023</enddate><creator>Faingold, Carl L.</creator><creator>Gehlbach, Greta</creator><creator>Caspary, Donald M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19891023</creationdate><title>On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies</title><author>Faingold, Carl L. ; Gehlbach, Greta ; Caspary, Donald M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-527f8ae7f4782d433ec9dca0d691700c6b56672725720f2992878c871dde5b6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acoustic Stimulation</topic><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Auditory Pathways - drug effects</topic><topic>Auditory Pathways - physiology</topic><topic>Benzodiazepine</topic><topic>Bicuculline</topic><topic>Bicuculline - pharmacology</topic><topic>Binaural inhibition</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Glycine</topic><topic>Inferior Colliculi - drug effects</topic><topic>Inferior Colliculi - physiology</topic><topic>Inferior colliculus</topic><topic>Neural Inhibition - drug effects</topic><topic>Nipecotic acid</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Strychnine</topic><topic>Strychnine - pharmacology</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faingold, Carl L.</creatorcontrib><creatorcontrib>Gehlbach, Greta</creatorcontrib><creatorcontrib>Caspary, Donald M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faingold, Carl L.</au><au>Gehlbach, Greta</au><au>Caspary, Donald M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1989-10-23</date><risdate>1989</risdate><volume>500</volume><issue>1</issue><spage>302</spage><epage>312</epage><pages>302-312</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of the remaining criteria for establishing transmitter identity by utilizing iontophoretic application onto IC neurons of agents affecting the action of γ-aminobutyric acid (GABA). The agents examined include GABA, a GABA B agonist (baclofen), a GABA A antagonist (bicuculline), a GABA uptake inhibitor (nipecotic acid), and a benzodiazepine (flurazepam), thought to exert its actions on the GABA receptor complex. Application of GABA results in inhibition of the spontaneous firing and acoustically evoked responses of inferior colliculus neurons. The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam. These agents as well as baclofen produce firing reductions when applied alone in higher doses. The effect of GABA can be blocked by application of bicuculline, and acoustically evoked (binaural) inhibition can also be selectively blocked by low doses of this GABA A antagonist. These data along with previous studies utilizing different techniques fulfill many of the criteria for establishment of GABA as an important inhibitory transmitter in the inferior colliculus.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2605499</pmid><doi>10.1016/0006-8993(89)90326-0</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0006-8993
ispartof Brain research, 1989-10, Vol.500 (1), p.302-312
issn 0006-8993
1872-6240
language eng
recordid cdi_proquest_miscellaneous_15387815
source MEDLINE; Elsevier ScienceDirect Journals
subjects Acoustic Stimulation
Action Potentials - drug effects
Animals
Auditory Pathways - drug effects
Auditory Pathways - physiology
Benzodiazepine
Bicuculline
Bicuculline - pharmacology
Binaural inhibition
gamma-Aminobutyric Acid - physiology
Glycine
Inferior Colliculi - drug effects
Inferior Colliculi - physiology
Inferior colliculus
Neural Inhibition - drug effects
Nipecotic acid
Rats
Rats, Inbred Strains
Strychnine
Strychnine - pharmacology
γ-Aminobutyric acid
title On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T07%3A15%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=On%20the%20role%20of%20GABA%20as%20an%20inhibitory%20neurotransmitter%20in%20inferior%20colliculus%20neurons:%20iontophoretic%20studies&rft.jtitle=Brain%20research&rft.au=Faingold,%20Carl%20L.&rft.date=1989-10-23&rft.volume=500&rft.issue=1&rft.spage=302&rft.epage=312&rft.pages=302-312&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/0006-8993(89)90326-0&rft_dat=%3Cproquest_cross%3E15387815%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15387815&rft_id=info:pmid/2605499&rft_els_id=0006899389903260&rfr_iscdi=true