Carcinogenic Properties of N-nitrodimethylamine and N-nitromethylamine in the rat

Male and female BDVI rats were treated with 1 mmol/kg × week and 0.5 mmol/kg × week fo N-nitrodimethylamine (NTDMA) or N-nitromethylamine (NTMA). NTMA induced mainly tumors of the nasal cavity (esthesioneuroepithelioma) while NTMA induced neurinoma of the spine, spinal nerves and peripheral nerves....

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Veröffentlicht in:	Carcinogenesis (New York) 1989-11, Vol.10 (11), p.1977-1981
Hauptverfasser:	Scherf, H. R., Frei, E., Wiessler, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens Chemical agents Dimethylamines Female Male Medical sciences Methylamines Neoplasms, Experimental - chemically induced Neoplasms, Experimental - pathology Rats Survival Analysis Tumors
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container_end_page	1981
container_issue	11
container_start_page	1977
container_title	Carcinogenesis (New York)
container_volume	10
creator	Scherf, H. R. Frei, E. Wiessler, M.
description	Male and female BDVI rats were treated with 1 mmol/kg × week and 0.5 mmol/kg × week fo N-nitrodimethylamine (NTDMA) or N-nitromethylamine (NTMA). NTMA induced mainly tumors of the nasal cavity (esthesioneuroepithelioma) while NTMA induced neurinoma of the spine, spinal nerves and peripheral nerves. NTMA was slightly less potent than the dimethyl compound. Females were less susceptible than males to the carcinogenic action of the nitramines.
doi_str_mv	10.1093/carcin/10.11.1977
format	Article
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source	MEDLINE; Oxford University Press Journals Digital Archive Legacy
subjects	Administration, Oral Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens Chemical agents Dimethylamines Female Male Medical sciences Methylamines Neoplasms, Experimental - chemically induced Neoplasms, Experimental - pathology Rats Survival Analysis Tumors
title	Carcinogenic Properties of N-nitrodimethylamine and N-nitromethylamine in the rat
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