A Synthetic Biotinylated Peptide, BP21, Inhibits the Induction of mRNA Expression of Inflammatory Substances by Oxidized- and Lyso-Phosphatidylcholine

Preclinical Research Oxidized low‐density lipoprotein (ox‐LDL) is implicated in many inflammatory diseases, e.g., type 2 diabetes, obesity, atherosclerosis, and metabolic syndrome. We previously reported that a synthetic biotinylated peptide, BP21, inhibits the bioactivity of ox‐LDL via direct bindi...

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Veröffentlicht in:	Drug development research 2014-06, Vol.75 (4), p.246-256
Hauptverfasser:	Sato, Akira, Kumagai, Takeshi, Ebina, Keiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells adipocyte Adipocytes Adipocytes - drug effects Adipocytes - immunology Animals anti-inflammatory drug Biotin - analogs & derivatives Biotin - chemistry Biotin - pharmacology biotinylated peptide Biotinylation Cell Line, Tumor Cytokines Gene Expression Regulation - drug effects Hemolysin Proteins - chemistry Hemolysin Proteins - pharmacology Humans inflammation Kinases Lipoproteins, LDL - antagonists & inhibitors lysophosphatidylcholine Lysophosphatidylcholines - immunology Mice monocyte/macrophage Monocytes - drug effects Monocytes - immunology oxidized phosphatidylcholine Peptide Fragments - chemistry Peptide Fragments - pharmacology Peptides - chemistry Peptides - pharmacology Phosphatidylcholines - immunology RNA, Messenger - metabolism
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