Repair of naphthalene-induced acute tracheal injury by basal cells depends on β-catenin

Objectives Little is known about the role of Wnt/β-catenin in postnatal airway homeostasis and basal cell function. This study aimed to investigate the role of Wnt signaling in the self-renewal of basal cells and the involvement of β-catenin in tracheal repair after naphthalene-induced injury. Metho...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2014-07, Vol.148 (1), p.322-332
Hauptverfasser:	Hsu, Han-Shui, MD, PhD, Liu, Chen-Chi, MD, Lin, Jiun-Han, MS, Hsu, Tien-Wei, MS, Su, Kelly, BS, Hung, Shih-Chieh, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Cardiothoracic Surgery Cell Proliferation - drug effects Cells, Cultured Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Forkhead Transcription Factors - metabolism Keratin-15 Keratin-5 - genetics Keratin-5 - metabolism Ki-67 Antigen - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Naphthalenes - toxicity Regeneration - drug effects Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Stem Cells - drug effects Stem Cells - metabolism Stem Cells - pathology Time Factors Trachea - drug effects Trachea - metabolism Trachea - pathology Uteroglobin - metabolism Wnt Signaling Pathway - drug effects
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