Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study
Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted o...
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| Veröffentlicht in: | Head & neck 2014-07, Vol.36 (7), p.998-1004 |
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| creator | Amit, Moran Binenbaum, Yoav Sharma, Kanika Ramer, Naomi Ramer, Ilana Agbetoba, Abib Miles, Brett Yang, Xinjie Lei, Delin Bjøerndal, Kristine Godballe, Christian Mücke, Thomas Wolff, Klaus-Dietrich Fliss, Dan Eckardt, André M. Copelli, Chiara Sesenna, Enrico Palmer, Frank Patel, Snehal Gil, Ziv |
| description | Background
Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure.
Methods
An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide.
Results
Five‐year overall‐survival (OS), disease‐specific survival (DSS), and disease‐free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases.
Conclusion
The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 998–1004, 2014 |
| doi_str_mv | 10.1002/hed.23405 |
| format | Article |
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Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure.
Methods
An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide.
Results
Five‐year overall‐survival (OS), disease‐specific survival (DSS), and disease‐free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases.
Conclusion
The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 998–1004, 2014</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23405</identifier><identifier>PMID: 23784851</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>adenoid ; adenoid cystic ; adenoid cystic carcinoma ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cancer Care Facilities ; Carcinoma, Adenoid Cystic - mortality ; Carcinoma, Adenoid Cystic - pathology ; Carcinoma, Adenoid Cystic - therapy ; Female ; head and neck cancer ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Neck Dissection ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Retrospective Studies ; salivary gland tumors ; Treatment Failure ; Young Adult</subject><ispartof>Head & neck, 2014-07, Vol.36 (7), p.998-1004</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-e81c8c0235c8fb9589adca4cc77a34f1e9202145b75ba9f3d336f9baea5d38e03</citedby><cites>FETCH-LOGICAL-c3915-e81c8c0235c8fb9589adca4cc77a34f1e9202145b75ba9f3d336f9baea5d38e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23405$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23405$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23784851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amit, Moran</creatorcontrib><creatorcontrib>Binenbaum, Yoav</creatorcontrib><creatorcontrib>Sharma, Kanika</creatorcontrib><creatorcontrib>Ramer, Naomi</creatorcontrib><creatorcontrib>Ramer, Ilana</creatorcontrib><creatorcontrib>Agbetoba, Abib</creatorcontrib><creatorcontrib>Miles, Brett</creatorcontrib><creatorcontrib>Yang, Xinjie</creatorcontrib><creatorcontrib>Lei, Delin</creatorcontrib><creatorcontrib>Bjøerndal, Kristine</creatorcontrib><creatorcontrib>Godballe, Christian</creatorcontrib><creatorcontrib>Mücke, Thomas</creatorcontrib><creatorcontrib>Wolff, Klaus-Dietrich</creatorcontrib><creatorcontrib>Fliss, Dan</creatorcontrib><creatorcontrib>Eckardt, André M.</creatorcontrib><creatorcontrib>Copelli, Chiara</creatorcontrib><creatorcontrib>Sesenna, Enrico</creatorcontrib><creatorcontrib>Palmer, Frank</creatorcontrib><creatorcontrib>Patel, Snehal</creatorcontrib><creatorcontrib>Gil, Ziv</creatorcontrib><title>Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure.
Methods
An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide.
Results
Five‐year overall‐survival (OS), disease‐specific survival (DSS), and disease‐free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases.
Conclusion
The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 998–1004, 2014</description><subject>adenoid</subject><subject>adenoid cystic</subject><subject>adenoid cystic carcinoma</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer Care Facilities</subject><subject>Carcinoma, Adenoid Cystic - mortality</subject><subject>Carcinoma, Adenoid Cystic - pathology</subject><subject>Carcinoma, Adenoid Cystic - therapy</subject><subject>Female</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neck Dissection</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Metastasis</subject><subject>Retrospective Studies</subject><subject>salivary gland tumors</subject><subject>Treatment Failure</subject><subject>Young Adult</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAURiMEoqWw4A8gS2xgkamda8fOclRKp1LFQ-KxtBznRuM2Y0_thDb_vp5OhwUSKz90vqNrf0XxltEFo7Q6XWO3qIBT8aw4ZrSRJQUun-_2HEqgkh8Vr1K6ppRCzauXxVEFUnEl2HFxv_RmmJNLJPSkN26YIhLnydaMDv2YyJ0b18R06IPriJ3T6CyxJlrnw8bsQuMayRpNR4zviEd7syBLnxUjRp8lIfuJDcNg2hDz-Q-SNE7d_Lp40Zsh4Zun9aT4-fn8x9mqvPp6cXm2vCotNEyUqJhVllYgrOrbRqjGdNZwa6U0wHuGTUUrxkUrRWuaHjqAum9ag0Z0oJDCSfFh793GcDthGvXGJYt5Ho9hSpoJkEzxpuEZff8Peh2m_IjhkRI1CCpVpj7uKRtDShF7vY1uY-KsGdW7OnSuQz_Wkdl3T8ap3eTbA3n4_wyc7oE7N-D8f5NenX86KMt9wqUR7_8mTLzRtQQp9O8vF1pW6vuqhl_6GzwA6P2jkA</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Amit, Moran</creator><creator>Binenbaum, Yoav</creator><creator>Sharma, Kanika</creator><creator>Ramer, Naomi</creator><creator>Ramer, Ilana</creator><creator>Agbetoba, Abib</creator><creator>Miles, Brett</creator><creator>Yang, Xinjie</creator><creator>Lei, Delin</creator><creator>Bjøerndal, Kristine</creator><creator>Godballe, Christian</creator><creator>Mücke, Thomas</creator><creator>Wolff, Klaus-Dietrich</creator><creator>Fliss, Dan</creator><creator>Eckardt, André M.</creator><creator>Copelli, Chiara</creator><creator>Sesenna, Enrico</creator><creator>Palmer, Frank</creator><creator>Patel, Snehal</creator><creator>Gil, Ziv</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201407</creationdate><title>Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study</title><author>Amit, Moran ; Binenbaum, Yoav ; Sharma, Kanika ; Ramer, Naomi ; Ramer, Ilana ; Agbetoba, Abib ; Miles, Brett ; Yang, Xinjie ; Lei, Delin ; Bjøerndal, Kristine ; Godballe, Christian ; Mücke, Thomas ; Wolff, Klaus-Dietrich ; Fliss, Dan ; Eckardt, André M. ; Copelli, Chiara ; Sesenna, Enrico ; Palmer, Frank ; Patel, Snehal ; Gil, Ziv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3915-e81c8c0235c8fb9589adca4cc77a34f1e9202145b75ba9f3d336f9baea5d38e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>adenoid</topic><topic>adenoid cystic</topic><topic>adenoid cystic carcinoma</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer Care Facilities</topic><topic>Carcinoma, Adenoid Cystic - mortality</topic><topic>Carcinoma, Adenoid Cystic - pathology</topic><topic>Carcinoma, Adenoid Cystic - therapy</topic><topic>Female</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neck Dissection</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Metastasis</topic><topic>Retrospective Studies</topic><topic>salivary gland tumors</topic><topic>Treatment Failure</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amit, Moran</creatorcontrib><creatorcontrib>Binenbaum, Yoav</creatorcontrib><creatorcontrib>Sharma, Kanika</creatorcontrib><creatorcontrib>Ramer, Naomi</creatorcontrib><creatorcontrib>Ramer, Ilana</creatorcontrib><creatorcontrib>Agbetoba, Abib</creatorcontrib><creatorcontrib>Miles, Brett</creatorcontrib><creatorcontrib>Yang, Xinjie</creatorcontrib><creatorcontrib>Lei, Delin</creatorcontrib><creatorcontrib>Bjøerndal, Kristine</creatorcontrib><creatorcontrib>Godballe, Christian</creatorcontrib><creatorcontrib>Mücke, Thomas</creatorcontrib><creatorcontrib>Wolff, Klaus-Dietrich</creatorcontrib><creatorcontrib>Fliss, Dan</creatorcontrib><creatorcontrib>Eckardt, André M.</creatorcontrib><creatorcontrib>Copelli, Chiara</creatorcontrib><creatorcontrib>Sesenna, Enrico</creatorcontrib><creatorcontrib>Palmer, Frank</creatorcontrib><creatorcontrib>Patel, Snehal</creatorcontrib><creatorcontrib>Gil, Ziv</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amit, Moran</au><au>Binenbaum, Yoav</au><au>Sharma, Kanika</au><au>Ramer, Naomi</au><au>Ramer, Ilana</au><au>Agbetoba, Abib</au><au>Miles, Brett</au><au>Yang, Xinjie</au><au>Lei, Delin</au><au>Bjøerndal, Kristine</au><au>Godballe, Christian</au><au>Mücke, Thomas</au><au>Wolff, Klaus-Dietrich</au><au>Fliss, Dan</au><au>Eckardt, André M.</au><au>Copelli, Chiara</au><au>Sesenna, Enrico</au><au>Palmer, Frank</au><au>Patel, Snehal</au><au>Gil, Ziv</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-07</date><risdate>2014</risdate><volume>36</volume><issue>7</issue><spage>998</spage><epage>1004</epage><pages>998-1004</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure.
Methods
An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide.
Results
Five‐year overall‐survival (OS), disease‐specific survival (DSS), and disease‐free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases.
Conclusion
The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 998–1004, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23784851</pmid><doi>10.1002/hed.23405</doi><tpages>7</tpages></addata></record> |
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| subjects | adenoid adenoid cystic adenoid cystic carcinoma Adolescent Adult Age Factors Aged Aged, 80 and over Cancer Care Facilities Carcinoma, Adenoid Cystic - mortality Carcinoma, Adenoid Cystic - pathology Carcinoma, Adenoid Cystic - therapy Female head and neck cancer Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Neck Dissection Neoplasm Invasiveness Neoplasm Metastasis Retrospective Studies salivary gland tumors Treatment Failure Young Adult |
| title | Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study |
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