PER1 and CLOCK: Potential circulating biomarkers for head and neck squamous cell carcinoma

Background Circadian clock regulates daily rhythms in various physiologic processes and deregulated circadian clock are linked to cancers. We have previously demonstrated the association between altered circadian clock genes (CCGs) and head and neck squamous cell carcinoma (HNSCC). The purpose of th...

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Veröffentlicht in:	Head & neck 2014-07, Vol.36 (7), p.1018-1026
Hauptverfasser:	Hsu, Cheng-Ming, Lin, Pai-Mei, Lai, Chi-Chih, Lin, Hsin-Ching, Lin, Sheng-Fung, Yang, Ming-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - blood Carcinoma, Squamous Cell - blood Case-Control Studies circadian clock genes CLOCK CLOCK Proteins - blood CLOCK Proteins - genetics Down-Regulation Female Head and Neck Neoplasms - blood head and neck squamous cell carcinoma Humans Immunohistochemistry Leukocytes, Mononuclear - metabolism Male Middle Aged PER1 Period Circadian Proteins - blood Period Circadian Proteins - genetics peripheral blood leukocytes Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism ROC Curve
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