Role of ligand in antibody-directed endocytosis of liposomes by human T-leukemia cells

The rate of uptake and intracellular processing of ligand-directed drug carriers may depend heavily on the endocytic pathway of the target antigen. We examined the role of the target antigen and type of antibody-liposome linkage in determining endocytosis of liposomes by three human T-cell leukemias...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1989-09, Vol.49 (17), p.4879-4886
Hauptverfasser:	MATTHAY, K. K, ABAI, A. M, COBB, S, HONG, K, PAPAHADJOPOULOS, D, STRAUBINGER, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antigens, Differentiation, T-Lymphocyte - immunology Antineoplastic agents Antineoplastic Agents - administration & dosage Biological and medical sciences Cell Division - drug effects Drug Carriers Endocytosis General aspects Humans Hydrogen-Ion Concentration leukemia Leukemia-Lymphoma, Adult T-Cell - metabolism Ligands Liposomes - immunology Liposomes - pharmacokinetics Medical sciences Microscopy, Fluorescence Pharmacology. Drug treatments Receptors, Transferrin - immunology Staphylococcal Protein A - metabolism Tumor Cells, Cultured
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