Seroepidemilogic Studies of Acute Hemorrhagic Conjunctivitis Virus (Enterovirus Type 70) in West Africa. I. Studies With Human Sera From Ghana Collected Eight Years After the First Outbreak

In 1969 and early 1970 , during the pre-epidemic period of acute hemorrhagic conjunctivitis (AHC) in the upper north regions of Ghana, 191 human sera were collected. In 1977, eight years after the first epidemic of AHC in Ghana, 1008 human sera were also collected in various regions of Ghana. These...

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Veröffentlicht in:American journal of epidemiology 1981-01, Vol.114 (2), p.267-273
Hauptverfasser: Kono, R, Minami, K, Otatsume, S, Mingle, JAA, Afoakwa, S N, Quarcoopome, C O, Konno, K, Uchida, Y, Kurahashi, H
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container_end_page 273
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container_title American journal of epidemiology
container_volume 114
creator Kono, R
Minami, K
Otatsume, S
Mingle, JAA
Afoakwa, S N
Quarcoopome, C O
Konno, K
Uchida, Y
Kurahashi, H
description In 1969 and early 1970 , during the pre-epidemic period of acute hemorrhagic conjunctivitis (AHC) in the upper north regions of Ghana, 191 human sera were collected. In 1977, eight years after the first epidemic of AHC in Ghana, 1008 human sera were also collected in various regions of Ghana. These sera were examined for virus neutralizing (VN) antibody against the J670/71 strain of enterovirus type 70 (EV70). In the pre-epidemic 1969-1970 sera, a low prevalence rate (6%) of VN antibody, with a titer of greater than or equal to 1:8, was found; the geometric mean titer (GMT) was also very low (1:1.25). In the post-epidemic 1977 sera, a high prevalence rate (53%) of VN antibody was found in the Ghanaian population, and the calculated GMT was also high (1:7.36). A higher antibody prevalence was detected in coastal, forest and peri-forest areas than in the tropical savanna area.
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title Seroepidemilogic Studies of Acute Hemorrhagic Conjunctivitis Virus (Enterovirus Type 70) in West Africa. I. Studies With Human Sera From Ghana Collected Eight Years After the First Outbreak
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