The reaction of 4-iodoacetamidosalicylic acid with TPN-dependent isocitrate dehydrogenase from pig heart

Salicylic acid acts as a reversible inhibitor of pig heart TPN-dependent isocitrate dehydrogenase competitive with manganous isocitrate (K sub(i) = 18.2 mM) but not with TPN. The salicylate derivative, 4-iodoacetamidosalicylic acid (0.5 to 4 mM), causes an irreversible time-dependent loss of both th...

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Veröffentlicht in:	The Journal of biological chemistry 1981-07, Vol.256 (13), p.6593-6599
Hauptverfasser:	Bacon, C R, Bednar, R A, Colman, R F
Format:	Artikel
Sprache:	eng
Schlagworte:	4-iodoacetamidosalicylic acid Animals Carboxy-Lyases - metabolism Iodoacetamide - analogs & derivatives Iodoacetamide - pharmacology isocitrate dehydrogenase (NADP super(+)) Isocitrate Dehydrogenase - metabolism Kinetics Ligands Myocardium - enzymology Oxaloacetates - metabolism Salicylates - pharmacology Swine
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