Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma
Abstract The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus,...
Gespeichert in:
| Veröffentlicht in: | Human immunology 2014-07, Vol.75 (7), p.667-672 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 672 |
|---|---|
| container_issue | 7 |
| container_start_page | 667 |
| container_title | Human immunology |
| container_volume | 75 |
| creator | Ramos, Caroline Steglich Gonçalves, Andréia Souza Marinho, Larissa Cardoso Gomes Avelino, Melissa Ameloti Saddi, Vera Aparecida Lopes, Aryanne Cristina Simões, Renata Toscano Wastowski, Isabela Jubé |
| description | Abstract The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus, the aim of this study was to evaluate the frequency of 14-bp insertion/deletion HLA-G polymorphism, as well as the expression of this molecule in patients with invasive breast ductal carcinoma (IDC). A significant association between the expression of HLA-G and the presence of metastasis in lymph nodes ( p = 0.01) was observed and the expression of HLA-G was significantly higher in patients with shorter survival time ( p = 0.03). The analysis suggests that the polymorphism observed in patients with IDC may be inducing a higher expression of the HLA-G molecule, which may possibly contribute to shorter survival time and a worse clinical prognosis for such patients. |
| doi_str_mv | 10.1016/j.humimm.2014.04.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1536685841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0198885914001165</els_id><sourcerecordid>1536685841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-7c166c6d8dda097cfd30a66079ddd460b9f82bebebd52df945bfdba7fd2509c93</originalsourceid><addsrcrecordid>eNqFUU2P0zAQtRCILQv_ACEfuaSM0_jrglStll2kShyAK5ZjT1iXJA52UtF_j6MuHLigedJc3sy8eY-Q1wy2DJh4d9w-LEMYhm0NrNlCAfAnZMOU1BVjQjwlG2BaVUpxfUVe5HwEAAmyeU6u6kZyLaTakG_70fbnHDKNHb0_7Ks7-h1HpFPsz0NM00PIA7Wjp1OKM4aR4q8pYc4hjjSsONkcTkjbhDbP1C9utj11NrkwxsG-JM8622d89divydcPt19u7qvDp7uPN_tD5Rom50q6ItgJr7y3oKXr_A6sECC1974R0OpO1S2W8rz2nW542_nWys7XHLTTu2vy9rK3yPy5YJ7NELLDvrcjxiUbxndCKK4aVqjNhepSzDlhZ6YUBpvOhoFZnTVHc3HWrM4aKABext48XljaAf3foT9WFsL7CwHLn6eAyWQXcHToQ0I3Gx_D_y78u8D1YQzO9j_wjPkYl1SyKr-YXBswn9d013BZA1AC57vfU7Ci1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1536685841</pqid></control><display><type>article</type><title>Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ramos, Caroline Steglich ; Gonçalves, Andréia Souza ; Marinho, Larissa Cardoso ; Gomes Avelino, Melissa Ameloti ; Saddi, Vera Aparecida ; Lopes, Aryanne Cristina ; Simões, Renata Toscano ; Wastowski, Isabela Jubé</creator><creatorcontrib>Ramos, Caroline Steglich ; Gonçalves, Andréia Souza ; Marinho, Larissa Cardoso ; Gomes Avelino, Melissa Ameloti ; Saddi, Vera Aparecida ; Lopes, Aryanne Cristina ; Simões, Renata Toscano ; Wastowski, Isabela Jubé</creatorcontrib><description>Abstract The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus, the aim of this study was to evaluate the frequency of 14-bp insertion/deletion HLA-G polymorphism, as well as the expression of this molecule in patients with invasive breast ductal carcinoma (IDC). A significant association between the expression of HLA-G and the presence of metastasis in lymph nodes ( p = 0.01) was observed and the expression of HLA-G was significantly higher in patients with shorter survival time ( p = 0.03). The analysis suggests that the polymorphism observed in patients with IDC may be inducing a higher expression of the HLA-G molecule, which may possibly contribute to shorter survival time and a worse clinical prognosis for such patients.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2014.04.005</identifier><identifier>PMID: 24759678</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alleles ; Allergy and Immunology ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - immunology ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - immunology ; Carcinoma, Ductal, Breast - mortality ; Carcinoma, Ductal, Breast - pathology ; Case-Control Studies ; Female ; Gene Expression ; Gene Frequency ; HLA-G ; HLA-G Antigens - genetics ; HLA-G Antigens - immunology ; Humans ; INDEL Mutation ; Lymph Nodes - immunology ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging ; Polymorphism ; Prognosis ; Prospective Studies ; Survival Analysis ; Tumor escape</subject><ispartof>Human immunology, 2014-07, Vol.75 (7), p.667-672</ispartof><rights>American Society for Histocompatibility and Immunogenetics</rights><rights>2014 American Society for Histocompatibility and Immunogenetics</rights><rights>Copyright © 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7c166c6d8dda097cfd30a66079ddd460b9f82bebebd52df945bfdba7fd2509c93</citedby><cites>FETCH-LOGICAL-c417t-7c166c6d8dda097cfd30a66079ddd460b9f82bebebd52df945bfdba7fd2509c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0198885914001165$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24759678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos, Caroline Steglich</creatorcontrib><creatorcontrib>Gonçalves, Andréia Souza</creatorcontrib><creatorcontrib>Marinho, Larissa Cardoso</creatorcontrib><creatorcontrib>Gomes Avelino, Melissa Ameloti</creatorcontrib><creatorcontrib>Saddi, Vera Aparecida</creatorcontrib><creatorcontrib>Lopes, Aryanne Cristina</creatorcontrib><creatorcontrib>Simões, Renata Toscano</creatorcontrib><creatorcontrib>Wastowski, Isabela Jubé</creatorcontrib><title>Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Abstract The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus, the aim of this study was to evaluate the frequency of 14-bp insertion/deletion HLA-G polymorphism, as well as the expression of this molecule in patients with invasive breast ductal carcinoma (IDC). A significant association between the expression of HLA-G and the presence of metastasis in lymph nodes ( p = 0.01) was observed and the expression of HLA-G was significantly higher in patients with shorter survival time ( p = 0.03). The analysis suggests that the polymorphism observed in patients with IDC may be inducing a higher expression of the HLA-G molecule, which may possibly contribute to shorter survival time and a worse clinical prognosis for such patients.</description><subject>Alleles</subject><subject>Allergy and Immunology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - immunology</subject><subject>Carcinoma, Ductal, Breast - mortality</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>HLA-G</subject><subject>HLA-G Antigens - genetics</subject><subject>HLA-G Antigens - immunology</subject><subject>Humans</subject><subject>INDEL Mutation</subject><subject>Lymph Nodes - immunology</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Polymorphism</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Survival Analysis</subject><subject>Tumor escape</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU2P0zAQtRCILQv_ACEfuaSM0_jrglStll2kShyAK5ZjT1iXJA52UtF_j6MuHLigedJc3sy8eY-Q1wy2DJh4d9w-LEMYhm0NrNlCAfAnZMOU1BVjQjwlG2BaVUpxfUVe5HwEAAmyeU6u6kZyLaTakG_70fbnHDKNHb0_7Ks7-h1HpFPsz0NM00PIA7Wjp1OKM4aR4q8pYc4hjjSsONkcTkjbhDbP1C9utj11NrkwxsG-JM8622d89divydcPt19u7qvDp7uPN_tD5Rom50q6ItgJr7y3oKXr_A6sECC1974R0OpO1S2W8rz2nW542_nWys7XHLTTu2vy9rK3yPy5YJ7NELLDvrcjxiUbxndCKK4aVqjNhepSzDlhZ6YUBpvOhoFZnTVHc3HWrM4aKABext48XljaAf3foT9WFsL7CwHLn6eAyWQXcHToQ0I3Gx_D_y78u8D1YQzO9j_wjPkYl1SyKr-YXBswn9d013BZA1AC57vfU7Ci1A</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Ramos, Caroline Steglich</creator><creator>Gonçalves, Andréia Souza</creator><creator>Marinho, Larissa Cardoso</creator><creator>Gomes Avelino, Melissa Ameloti</creator><creator>Saddi, Vera Aparecida</creator><creator>Lopes, Aryanne Cristina</creator><creator>Simões, Renata Toscano</creator><creator>Wastowski, Isabela Jubé</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma</title><author>Ramos, Caroline Steglich ; Gonçalves, Andréia Souza ; Marinho, Larissa Cardoso ; Gomes Avelino, Melissa Ameloti ; Saddi, Vera Aparecida ; Lopes, Aryanne Cristina ; Simões, Renata Toscano ; Wastowski, Isabela Jubé</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7c166c6d8dda097cfd30a66079ddd460b9f82bebebd52df945bfdba7fd2509c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alleles</topic><topic>Allergy and Immunology</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - immunology</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Carcinoma, Ductal, Breast - immunology</topic><topic>Carcinoma, Ductal, Breast - mortality</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>HLA-G</topic><topic>HLA-G Antigens - genetics</topic><topic>HLA-G Antigens - immunology</topic><topic>Humans</topic><topic>INDEL Mutation</topic><topic>Lymph Nodes - immunology</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Polymorphism</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Survival Analysis</topic><topic>Tumor escape</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos, Caroline Steglich</creatorcontrib><creatorcontrib>Gonçalves, Andréia Souza</creatorcontrib><creatorcontrib>Marinho, Larissa Cardoso</creatorcontrib><creatorcontrib>Gomes Avelino, Melissa Ameloti</creatorcontrib><creatorcontrib>Saddi, Vera Aparecida</creatorcontrib><creatorcontrib>Lopes, Aryanne Cristina</creatorcontrib><creatorcontrib>Simões, Renata Toscano</creatorcontrib><creatorcontrib>Wastowski, Isabela Jubé</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos, Caroline Steglich</au><au>Gonçalves, Andréia Souza</au><au>Marinho, Larissa Cardoso</au><au>Gomes Avelino, Melissa Ameloti</au><au>Saddi, Vera Aparecida</au><au>Lopes, Aryanne Cristina</au><au>Simões, Renata Toscano</au><au>Wastowski, Isabela Jubé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>75</volume><issue>7</issue><spage>667</spage><epage>672</epage><pages>667-672</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>Abstract The human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule predominantly expressed in trophoblastic placental cells to protect the fetus during pregnancy. However, evidence has shown that this molecule may be implicated in the immune escape mechanism of tumor cells. Thus, the aim of this study was to evaluate the frequency of 14-bp insertion/deletion HLA-G polymorphism, as well as the expression of this molecule in patients with invasive breast ductal carcinoma (IDC). A significant association between the expression of HLA-G and the presence of metastasis in lymph nodes ( p = 0.01) was observed and the expression of HLA-G was significantly higher in patients with shorter survival time ( p = 0.03). The analysis suggests that the polymorphism observed in patients with IDC may be inducing a higher expression of the HLA-G molecule, which may possibly contribute to shorter survival time and a worse clinical prognosis for such patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24759678</pmid><doi>10.1016/j.humimm.2014.04.005</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0198-8859 |
| ispartof | Human immunology, 2014-07, Vol.75 (7), p.667-672 |
| issn | 0198-8859 1879-1166 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1536685841 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alleles Allergy and Immunology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - immunology Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Case-Control Studies Female Gene Expression Gene Frequency HLA-G HLA-G Antigens - genetics HLA-G Antigens - immunology Humans INDEL Mutation Lymph Nodes - immunology Lymph Nodes - pathology Lymphatic Metastasis Middle Aged Neoplasm Staging Polymorphism Prognosis Prospective Studies Survival Analysis Tumor escape |
| title | Analysis of HLA-G gene polymorphism and protein expression in invasive breast ductal carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T07%3A24%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20HLA-G%20gene%20polymorphism%20and%20protein%20expression%20in%20invasive%20breast%20ductal%20carcinoma&rft.jtitle=Human%20immunology&rft.au=Ramos,%20Caroline%20Steglich&rft.date=2014-07-01&rft.volume=75&rft.issue=7&rft.spage=667&rft.epage=672&rft.pages=667-672&rft.issn=0198-8859&rft.eissn=1879-1166&rft_id=info:doi/10.1016/j.humimm.2014.04.005&rft_dat=%3Cproquest_cross%3E1536685841%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1536685841&rft_id=info:pmid/24759678&rft_els_id=S0198885914001165&rfr_iscdi=true |