Pharmacokinetic simulations to explore dissolution criteria of BCS I and III biowaivers with and without MDR-1 efflux transporter

[Display omitted] In this study, a pharmacokinetic simulation model was used to explore the dissolution acceptance criteria for BCS I and III biowaivers and to examine the risk of MDR-1 efflux transporter on bioequivalence of substrates. The compartmental absorption and transit (CAT) model with one-...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2014-09, Vol.61, p.18-26
Hauptverfasser:	Kortejärvi, H., Malkki, J., Shawahna, R., Scherrmann, J.-M., Urtti, A., Yliperttula, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption, Physiological ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B - metabolism BCS Bioequivalence Biological Transport Biopharmaceutics - classification Biowaiver Compartmental absorption and transit model Drug dissolution Humans Pharmaceutical Preparations - metabolism Pharmacokinetic simulation Pharmacokinetics Therapeutic Equivalency
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