Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits

Decreased expression of CHRNA7, the gene encoding the α7(∗) subtype of nicotinic receptor, may contribute to the cognitive dysfunction observed in schizophrenia by disrupting the inhibitory/excitatory balance in the hippocampus. C3H mice with reduced Chrna7 expression have significant reductions in...

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Veröffentlicht in:	Neuroscience 2014-07, Vol.273, p.52-64
Hauptverfasser:	Bates, R C, Stith, B J, Stevens, K E, Adams, C E
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor - genetics alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Blotting, Western Female Genotype Glutamate Decarboxylase - metabolism Hippocampus - physiopathology Male Mice, Inbred C3H Mice, Knockout Parvalbumins - metabolism Receptors, GABA-A - metabolism Sex Characteristics
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