Condition-specific target prediction from motifs and expression

It is commonplace to predict targets of transcription factors (TFs) by sequence matching with their binding motifs. However, this ignores the particular condition of the cells. Gene expression data can provide condition-specific information, as is, e.g. exploited in Motif Enrichment Analysis. Here,...

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Veröffentlicht in:	Bioinformatics (Oxford, England) England), 2014-06, Vol.30 (12), p.1643-1650
Hauptverfasser:	Meng, Guofeng, Vingron, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Chromatin Immunoprecipitation Estradiol - pharmacology Gene Expression Profiling Humans MCF-7 Cells Nucleotide Motifs Oligonucleotide Array Sequence Analysis Position-Specific Scoring Matrices Promoter Regions, Genetic Receptors, Estrogen - metabolism Regulatory Elements, Transcriptional Software Transcription Factors - metabolism
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