Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates

The purpose of this study was to characterize the transport properties of trimetrexate in WI-L2 human lymphoblastoid cells and determine the mode of resistance that had developed in a subline, WI-L2/TMQ, that was grown in increasing concentrations of trimetrexate. WI-L2/TMQ cells were 62-fold resist...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1988-12, Vol.48 (24), p.6986-6991
Hauptverfasser:	FRY, D. W, BESSERER, J. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Antineoplastic agents Azides - pharmacology Biological and medical sciences Cell Line Dose-Response Relationship, Drug Drug Resistance Folic Acid Antagonists - pharmacology General aspects Humans Lymphocytes - drug effects Lymphocytes - metabolism Medical sciences metoprine Pharmacology. Drug treatments piritrexim Pyrimidines - pharmacology Quinazolines - pharmacokinetics Sodium Azide Trimetrexate
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