Transformation of C3H/10T1/2 mouse embryo cells to focus formation and anchorage independence by insoluble lead chromate but not soluble calcium chromate: relationship to mutagenesis and internalization of lead chromate particles

The genotoxicity of soluble and insoluble hexavalent chromium compounds was studied in mammalian cell assays which detect base substitution, deletion, addition, and frameshift mutations [6-thioguanine resistance in Chinese hamster ovary cells], primarily base substitution mutations [ouabain resistan...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1988-09, Vol.48 (18), p.5280-5288
Hauptverfasser:	PATIERNO, S. R, BANH, D, LANDOLPH, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Animals Biological and medical sciences Calcium Compounds Cell Transformation, Neoplastic Cells, Cultured Chemical mutagenesis Chromates - pharmacology Lead - pharmacology lead chromate Medical sciences Mice Mice, Inbred C3H Microscopy, Electron Mutagenicity Tests Ouabain - pharmacology Thioguanine - pharmacology Toxicology
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