Effects of streptozotocin-induced hyperglycemia on agonist-stimulated phosphatidylinositol turnover in rat aorta

Altered vascular sensitivity and responsiveness has been previously described in various stages of experimental diabetes mellitus. Increases in membrane bound Ca 2+ and intracellular calcium in diabetic aorta have been postulated to explain excitation-coupling dysfunction in diabetic vascular smooth...

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Veröffentlicht in:	Life sciences (1973) 1989, Vol.45 (5), p.371-378
1. Verfasser:	Legan, Eugenia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aorta Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - physiopathology Biological and medical sciences Blood Glucose - metabolism Body Weight Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance hyperglycemia Hyperglycemia - chemically induced Hyperglycemia - metabolism In Vitro Techniques Inositol - metabolism Inositol Phosphates - biosynthesis Inositol Phosphates - isolation & purification Male Medical sciences Muscle Contraction Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiopathology Norepinephrine - pharmacology Phenylephrine - pharmacology phosphatidylinositol Phosphatidylinositols - metabolism Rats Rats, Inbred Strains Reference Values Serotonin - pharmacology Streptozocin Sugar Phosphates - biosynthesis
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