Effect of a concomitant single dose of ethanol on the hepatotoxicity and metabolism of acetaminophen in mice

A concomitant single dose of ethanol (1 g/kg) protected mice from hepatic injury induced by acetaminophen (250 mg/kg) as evidenced by the lowering of plasma transaminases. Pharmacokinetic studies with [ 14C]acetaminophen indicated that ethanol enhanced the initial blood concentrations of radiolabel...

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Veröffentlicht in:	Toxicology (Amsterdam) 1980, Vol.17 (3), p.297-309
Hauptverfasser:	Wong, L.T., Whitehouse, L.W., Solomonraj, G., Paul, C.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - metabolism Acetaminophen - toxicity Animals Bile - metabolism Biotransformation - drug effects Ethanol - pharmacology Liver - drug effects Liver - metabolism Male Mice Tissue Distribution Transaminases - blood
Online-Zugang:	Volltext
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