Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells

This study aimed to examine the effect of apigenin on proliferation and apoptosis in HER2-overexpressing MDA-MB-453 breast cancer cells. The antiproliferative effects of apigenin were examined by proliferation and MTT assays. The effect of apigenin on apoptotic molecules was determined by western bl...

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Veröffentlicht in:	Anticancer research 2014-06, Vol.34 (6), p.2869-2882
Hauptverfasser:	Seo, Hye-Sook, Ku, Jin Mo, Choi, Han-Seok, Woo, Jong-Kyu, Jang, Bo-Hyoung, Shin, Yong Cheol, Ko, Seong-Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apigenin - pharmacology Apoptosis - drug effects Blotting, Western Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - pathology Caspases - genetics Caspases - metabolism Cell Cycle - drug effects Cell Proliferation - drug effects Female Flow Cytometry Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunoenzyme Techniques Phosphorylation - drug effects Real-Time Polymerase Chain Reaction Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor Cells, Cultured Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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