Possible benefit of splenectomy in liver transplantation for autoimmune hepatitis
Abstract Liver transplantation for autoimmune hepatitis (AIH) is usually successful with excellent long-term outcomes, but primary disease may recur. The recurrence of AIH is a significant cause of graft loss. This study was to analyze the effect of splenectomy in preventing AIH relapse. The clinica...
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| Veröffentlicht in: | Hepatobiliary & pancreatic diseases international 2014-06, Vol.13 (3), p.328-331 |
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| creator | Xu, Yan-Tian Liu, De-Jie Meng, Fan-Ying Li, Guang-Bing Liu, Jun |
| description | Abstract Liver transplantation for autoimmune hepatitis (AIH) is usually successful with excellent long-term outcomes, but primary disease may recur. The recurrence of AIH is a significant cause of graft loss. This study was to analyze the effect of splenectomy in preventing AIH relapse. The clinical courses of 12 patients who had transplantation for AIH were analyzed retrospectively. All patients were subjected to transplantation for end-stage liver disease caused by chronic AIH. Based on the duration of immunosuppressive treatment before liver transplantation, simultaneous splenectomy was performed in ten patients. Two patients underwent liver transplantation without splenectomy, one of them developed recurrent AIH and died from graft failure caused by AIH relapse. However, no episode of AIH recurrence was observed in patients who had undergone simultaneous splenectomy. Splenectomy might be an option to prevent AIH relapse in some patients with high risk factors. |
| doi_str_mv | 10.1016/S1499-3872(14)60256-3 |
| format | Article |
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The recurrence of AIH is a significant cause of graft loss. This study was to analyze the effect of splenectomy in preventing AIH relapse. The clinical courses of 12 patients who had transplantation for AIH were analyzed retrospectively. All patients were subjected to transplantation for end-stage liver disease caused by chronic AIH. Based on the duration of immunosuppressive treatment before liver transplantation, simultaneous splenectomy was performed in ten patients. Two patients underwent liver transplantation without splenectomy, one of them developed recurrent AIH and died from graft failure caused by AIH relapse. However, no episode of AIH recurrence was observed in patients who had undergone simultaneous splenectomy. Splenectomy might be an option to prevent AIH relapse in some patients with high risk factors.</description><identifier>ISSN: 1499-3872</identifier><identifier>DOI: 10.1016/S1499-3872(14)60256-3</identifier><identifier>PMID: 24919618</identifier><language>eng</language><publisher>Singapore: Elsevier B.V</publisher><subject>Adult ; Aged ; autoimmune hepatitis ; End Stage Liver Disease - diagnosis ; End Stage Liver Disease - etiology ; End Stage Liver Disease - mortality ; End Stage Liver Disease - surgery ; Endocrinology & Metabolism ; Female ; Gastroenterology and Hepatology ; Hepatitis, Autoimmune - complications ; Hepatitis, Autoimmune - diagnosis ; Hepatitis, Autoimmune - mortality ; Hepatitis, Autoimmune - surgery ; Humans ; Immunosuppressive Agents - administration & dosage ; liver transplantation ; Liver Transplantation - adverse effects ; Liver Transplantation - mortality ; Middle Aged ; Recurrence ; Retrospective Studies ; Risk Factors ; splenectomy ; Splenectomy - adverse effects ; Splenectomy - mortality ; Time Factors ; Treatment Outcome</subject><ispartof>Hepatobiliary & pancreatic diseases international, 2014-06, Vol.13 (3), p.328-331</ispartof><rights>The Editorial Board of Hepatobiliary & Pancreatic Diseases International</rights><rights>2014 The Editorial Board of Hepatobiliary & Pancreatic Diseases International</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-9204dc2875a946b67ad642822621ca78ea3bc2a75491451fee26adcb2cf95cb73</citedby><cites>FETCH-LOGICAL-c514t-9204dc2875a946b67ad642822621ca78ea3bc2a75491451fee26adcb2cf95cb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/89801X/89801X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1499-3872(14)60256-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24919618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Yan-Tian</creatorcontrib><creatorcontrib>Liu, De-Jie</creatorcontrib><creatorcontrib>Meng, Fan-Ying</creatorcontrib><creatorcontrib>Li, Guang-Bing</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><title>Possible benefit of splenectomy in liver transplantation for autoimmune hepatitis</title><title>Hepatobiliary & pancreatic diseases international</title><addtitle>Hepatobiliary & Pancreatic Diseases International</addtitle><description>Abstract Liver transplantation for autoimmune hepatitis (AIH) is usually successful with excellent long-term outcomes, but primary disease may recur. The recurrence of AIH is a significant cause of graft loss. This study was to analyze the effect of splenectomy in preventing AIH relapse. The clinical courses of 12 patients who had transplantation for AIH were analyzed retrospectively. All patients were subjected to transplantation for end-stage liver disease caused by chronic AIH. Based on the duration of immunosuppressive treatment before liver transplantation, simultaneous splenectomy was performed in ten patients. Two patients underwent liver transplantation without splenectomy, one of them developed recurrent AIH and died from graft failure caused by AIH relapse. However, no episode of AIH recurrence was observed in patients who had undergone simultaneous splenectomy. Splenectomy might be an option to prevent AIH relapse in some patients with high risk factors.</description><subject>Adult</subject><subject>Aged</subject><subject>autoimmune hepatitis</subject><subject>End Stage Liver Disease - diagnosis</subject><subject>End Stage Liver Disease - etiology</subject><subject>End Stage Liver Disease - mortality</subject><subject>End Stage Liver Disease - surgery</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Hepatitis, Autoimmune - complications</subject><subject>Hepatitis, Autoimmune - diagnosis</subject><subject>Hepatitis, Autoimmune - mortality</subject><subject>Hepatitis, Autoimmune - surgery</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>liver transplantation</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver Transplantation - mortality</subject><subject>Middle Aged</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>splenectomy</subject><subject>Splenectomy - adverse effects</subject><subject>Splenectomy - mortality</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1499-3872</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3TAQhb0AFQr8BCpLbGCR4neSDRVC9CEhtRXt2nKcCRgS-2I7SPff4_soQt2wsjxz5ps5B6FjSj5TQtX5LRVtW_GmZqdUnCnCpKr4Dtp_Le-hjyk9EMKaRqoPaI-JlraKNvvo96-QkutGwB14GFzGYcBpMZaPzWFaYufx6J4h4hyNLw3js8kueDyEiM2cg5um2QO-h0WpZ5cO0e5gxgRH2_cA_f16_efqe3Xz89uPq8ubykoqctUyInrLmlqaVqhO1aZXgjWMKUatqRswvLPM1LKcKiQdAJgyve2YHVppu5ofoNMNdxHD0wwp68klC2O5EMKcNJVcqsJvaJHKjdTG4jbCoBfRTSYuNSV6laBeJ6hXUWkq9DpBzcvcp-2KuZugf536F18RfNkIoBh9dhB1sg68hd7Fkp_ug3t3xcV_BDs676wZH2EJ6SHM0ZcUNdWJabKBrBhUrAkrwMnW233wd0_O370xRzjhQjLOXwAtwKPe</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Xu, Yan-Tian</creator><creator>Liu, De-Jie</creator><creator>Meng, Fan-Ying</creator><creator>Li, Guang-Bing</creator><creator>Liu, Jun</creator><general>Elsevier B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Possible benefit of splenectomy in liver transplantation for autoimmune hepatitis</title><author>Xu, Yan-Tian ; Liu, De-Jie ; Meng, Fan-Ying ; Li, Guang-Bing ; Liu, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-9204dc2875a946b67ad642822621ca78ea3bc2a75491451fee26adcb2cf95cb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>autoimmune hepatitis</topic><topic>End Stage Liver Disease - diagnosis</topic><topic>End Stage Liver Disease - etiology</topic><topic>End Stage Liver Disease - mortality</topic><topic>End Stage Liver Disease - surgery</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Hepatitis, Autoimmune - complications</topic><topic>Hepatitis, Autoimmune - diagnosis</topic><topic>Hepatitis, Autoimmune - mortality</topic><topic>Hepatitis, Autoimmune - surgery</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>liver transplantation</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver Transplantation - mortality</topic><topic>Middle Aged</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>splenectomy</topic><topic>Splenectomy - adverse effects</topic><topic>Splenectomy - mortality</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Yan-Tian</creatorcontrib><creatorcontrib>Liu, De-Jie</creatorcontrib><creatorcontrib>Meng, Fan-Ying</creatorcontrib><creatorcontrib>Li, Guang-Bing</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatobiliary & pancreatic diseases international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Yan-Tian</au><au>Liu, De-Jie</au><au>Meng, Fan-Ying</au><au>Li, Guang-Bing</au><au>Liu, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible benefit of splenectomy in liver transplantation for autoimmune hepatitis</atitle><jtitle>Hepatobiliary & pancreatic diseases international</jtitle><addtitle>Hepatobiliary & Pancreatic Diseases International</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>13</volume><issue>3</issue><spage>328</spage><epage>331</epage><pages>328-331</pages><issn>1499-3872</issn><abstract>Abstract Liver transplantation for autoimmune hepatitis (AIH) is usually successful with excellent long-term outcomes, but primary disease may recur. The recurrence of AIH is a significant cause of graft loss. This study was to analyze the effect of splenectomy in preventing AIH relapse. The clinical courses of 12 patients who had transplantation for AIH were analyzed retrospectively. All patients were subjected to transplantation for end-stage liver disease caused by chronic AIH. Based on the duration of immunosuppressive treatment before liver transplantation, simultaneous splenectomy was performed in ten patients. Two patients underwent liver transplantation without splenectomy, one of them developed recurrent AIH and died from graft failure caused by AIH relapse. However, no episode of AIH recurrence was observed in patients who had undergone simultaneous splenectomy. Splenectomy might be an option to prevent AIH relapse in some patients with high risk factors.</abstract><cop>Singapore</cop><pub>Elsevier B.V</pub><pmid>24919618</pmid><doi>10.1016/S1499-3872(14)60256-3</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged autoimmune hepatitis End Stage Liver Disease - diagnosis End Stage Liver Disease - etiology End Stage Liver Disease - mortality End Stage Liver Disease - surgery Endocrinology & Metabolism Female Gastroenterology and Hepatology Hepatitis, Autoimmune - complications Hepatitis, Autoimmune - diagnosis Hepatitis, Autoimmune - mortality Hepatitis, Autoimmune - surgery Humans Immunosuppressive Agents - administration & dosage liver transplantation Liver Transplantation - adverse effects Liver Transplantation - mortality Middle Aged Recurrence Retrospective Studies Risk Factors splenectomy Splenectomy - adverse effects Splenectomy - mortality Time Factors Treatment Outcome |
| title | Possible benefit of splenectomy in liver transplantation for autoimmune hepatitis |
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