Comparative behavior. Anxiety-like behavior in crayfish is controlled by serotonin
Anxiety, a behavioral consequence of stress, has been characterized in humans and some vertebrates, but not invertebrates. Here, we demonstrate that after exposure to stress, crayfish sustainably avoided the aversive illuminated arms of an aquatic plus-maze. This behavior was correlated with an incr...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2014-06, Vol.344 (6189), p.1293-1297 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Fossat, Pascal Bacqué-Cazenave, Julien De Deurwaerdère, Philippe Delbecque, Jean-Paul Cattaert, Daniel |
| description | Anxiety, a behavioral consequence of stress, has been characterized in humans and some vertebrates, but not invertebrates. Here, we demonstrate that after exposure to stress, crayfish sustainably avoided the aversive illuminated arms of an aquatic plus-maze. This behavior was correlated with an increase in brain serotonin and was abolished by the injection of the benzodiazepine anxiolytic chlordiazepoxide. Serotonin injection into unstressed crayfish induced avoidance; again, this effect was reversed by injection with chlordiazepoxide. Our results demonstrate that crayfish exhibit a form of anxiety similar to that described in vertebrates, suggesting the conservation of several underlying mechanisms during evolution. Analyses of this ancestral behavior in a simple model reveal a new route to understanding anxiety and may alter our conceptions of the emotional status of invertebrates. |
| doi_str_mv | 10.1126/science.1248811 |
| format | Article |
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Anxiety-like behavior in crayfish is controlled by serotonin</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Fossat, Pascal ; Bacqué-Cazenave, Julien ; De Deurwaerdère, Philippe ; Delbecque, Jean-Paul ; Cattaert, Daniel</creator><creatorcontrib>Fossat, Pascal ; Bacqué-Cazenave, Julien ; De Deurwaerdère, Philippe ; Delbecque, Jean-Paul ; Cattaert, Daniel</creatorcontrib><description>Anxiety, a behavioral consequence of stress, has been characterized in humans and some vertebrates, but not invertebrates. Here, we demonstrate that after exposure to stress, crayfish sustainably avoided the aversive illuminated arms of an aquatic plus-maze. This behavior was correlated with an increase in brain serotonin and was abolished by the injection of the benzodiazepine anxiolytic chlordiazepoxide. Serotonin injection into unstressed crayfish induced avoidance; again, this effect was reversed by injection with chlordiazepoxide. Our results demonstrate that crayfish exhibit a form of anxiety similar to that described in vertebrates, suggesting the conservation of several underlying mechanisms during evolution. Analyses of this ancestral behavior in a simple model reveal a new route to understanding anxiety and may alter our conceptions of the emotional status of invertebrates.</description><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1248811</identifier><identifier>PMID: 24926022</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Anxiety - chemically induced ; Anxiety - metabolism ; Astacoidea - drug effects ; Astacoidea - physiology ; Avoidance Learning ; Behavior, Animal - drug effects ; Benzodiazepines - pharmacology ; Biological Evolution ; Disease Models, Animal ; Maze Learning ; Serotonin - metabolism ; Serotonin - pharmacology ; Stress, Psychological - chemically induced ; Stress, Psychological - metabolism</subject><ispartof>Science (American Association for the Advancement of Science), 2014-06, Vol.344 (6189), p.1293-1297</ispartof><rights>Copyright © 2014, American Association for the Advancement of Science.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24926022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fossat, Pascal</creatorcontrib><creatorcontrib>Bacqué-Cazenave, Julien</creatorcontrib><creatorcontrib>De Deurwaerdère, Philippe</creatorcontrib><creatorcontrib>Delbecque, Jean-Paul</creatorcontrib><creatorcontrib>Cattaert, Daniel</creatorcontrib><title>Comparative behavior. 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Analyses of this ancestral behavior in a simple model reveal a new route to understanding anxiety and may alter our conceptions of the emotional status of invertebrates.</description><subject>Animals</subject><subject>Anxiety - chemically induced</subject><subject>Anxiety - metabolism</subject><subject>Astacoidea - drug effects</subject><subject>Astacoidea - physiology</subject><subject>Avoidance Learning</subject><subject>Behavior, Animal - drug effects</subject><subject>Benzodiazepines - pharmacology</subject><subject>Biological Evolution</subject><subject>Disease Models, Animal</subject><subject>Maze Learning</subject><subject>Serotonin - metabolism</subject><subject>Serotonin - pharmacology</subject><subject>Stress, Psychological - chemically induced</subject><subject>Stress, Psychological - metabolism</subject><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAYhoMgbk7P3iRHL5398qNtjmPoFAaC6Lkk6VcWbZOadMP-9w6ceHp5Xh7ew0vIDeRLAFbcJ-vQW1wCE1UFcEbmkCuZKZbzGblM6SPPj6z4BZkxoViRMzYnr-vQDzrq0R2QGtzpgwtxSVf-2-E4ZZ37_K-p89RGPbUu7ahL1AY_xtB12FAz0YQxjME7f0XOW90lvD7lgrw_Prytn7Lty-Z5vdpmAwgYM2kaQNvk2lhlsBSl5g0yKCxjoLCVBS-llIYDCFW0pQFVVlpIW9mmLFXD-ILc_e4OMXztMY1175LFrtMewz7VILksWMEEP6q3J3VvemzqIbpex6n--4H_ACUfXxk</recordid><startdate>20140613</startdate><enddate>20140613</enddate><creator>Fossat, Pascal</creator><creator>Bacqué-Cazenave, Julien</creator><creator>De Deurwaerdère, Philippe</creator><creator>Delbecque, Jean-Paul</creator><creator>Cattaert, Daniel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140613</creationdate><title>Comparative behavior. 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| ispartof | Science (American Association for the Advancement of Science), 2014-06, Vol.344 (6189), p.1293-1297 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Animals Anxiety - chemically induced Anxiety - metabolism Astacoidea - drug effects Astacoidea - physiology Avoidance Learning Behavior, Animal - drug effects Benzodiazepines - pharmacology Biological Evolution Disease Models, Animal Maze Learning Serotonin - metabolism Serotonin - pharmacology Stress, Psychological - chemically induced Stress, Psychological - metabolism |
| title | Comparative behavior. Anxiety-like behavior in crayfish is controlled by serotonin |
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