Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice
Metaphit induces audiogenic seizures in mice. The most severe clonic/tonic seizures occur 18–24 h after metaphit administration. After 48 h the incidence of the seizure episodes begin to diminish. These audiogenic seizures can be prevented by the administration of either PCP or MK-801 24 h after met...
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| Veröffentlicht in: | European journal of pharmacology 1989-06, Vol.165 (1), p.155-159 |
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| container_title | European journal of pharmacology |
| container_volume | 165 |
| creator | Debler, Edmund A. Lipovac, Milo N. Lajtha, Abel Zlokovic, Berislav V. Jacobson, Arthur E. Rice, Kenner C. Reith, Maarten E.A. |
| description | Metaphit induces audiogenic seizures in mice. The most severe clonic/tonic seizures occur 18–24 h after metaphit administration. After 48 h the incidence of the seizure episodes begin to diminish. These audiogenic seizures can be prevented by the administration of either PCP or MK-801 24 h after metaphit and 30 min prior to audio stimulation. These seizures may be due to a modulation of the PCP recognition site by metaphit which results in an enhanced probability that the NMDA/PCP ion channels are open. |
| doi_str_mv | 10.1016/0014-2999(89)90783-8 |
| format | Article |
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The most severe clonic/tonic seizures occur 18–24 h after metaphit administration. After 48 h the incidence of the seizure episodes begin to diminish. These audiogenic seizures can be prevented by the administration of either PCP or MK-801 24 h after metaphit and 30 min prior to audio stimulation. These seizures may be due to a modulation of the PCP recognition site by metaphit which results in an enhanced probability that the NMDA/PCP ion channels are open.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(89)90783-8</identifier><identifier>PMID: 2548879</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Animals ; Audiogenic seizures ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Injections ; Injections, Intravenous ; Medical sciences ; Metaphit ; Mice ; Mice, Inbred BALB C ; N-Methyl-D-aspartate (NMDA) ; Orbit ; Pharmacology. Drug treatments ; Phencyclidine (PCP) ; Phencyclidine - analogs & derivatives ; Phencyclidine - toxicity ; Receptors, N-Methyl-D-Aspartate ; Receptors, Neurotransmitter - drug effects ; Seizures - chemically induced ; Time Factors ; Toxicity: nervous system and muscle</subject><ispartof>European journal of pharmacology, 1989-06, Vol.165 (1), p.155-159</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c33dbce78475d4a100800046973c39f16c100e796eeb888e7ceb38dd15f3d47d3</citedby><cites>FETCH-LOGICAL-c417t-c33dbce78475d4a100800046973c39f16c100e796eeb888e7ceb38dd15f3d47d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(89)90783-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6764175$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2548879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Debler, Edmund A.</creatorcontrib><creatorcontrib>Lipovac, Milo N.</creatorcontrib><creatorcontrib>Lajtha, Abel</creatorcontrib><creatorcontrib>Zlokovic, Berislav V.</creatorcontrib><creatorcontrib>Jacobson, Arthur E.</creatorcontrib><creatorcontrib>Rice, Kenner C.</creatorcontrib><creatorcontrib>Reith, Maarten E.A.</creatorcontrib><title>Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Metaphit induces audiogenic seizures in mice. The most severe clonic/tonic seizures occur 18–24 h after metaphit administration. After 48 h the incidence of the seizure episodes begin to diminish. These audiogenic seizures can be prevented by the administration of either PCP or MK-801 24 h after metaphit and 30 min prior to audio stimulation. These seizures may be due to a modulation of the PCP recognition site by metaphit which results in an enhanced probability that the NMDA/PCP ion channels are open.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Audiogenic seizures</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Injections</subject><subject>Injections, Intravenous</subject><subject>Medical sciences</subject><subject>Metaphit</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>N-Methyl-D-aspartate (NMDA)</subject><subject>Orbit</subject><subject>Pharmacology. Drug treatments</subject><subject>Phencyclidine (PCP)</subject><subject>Phencyclidine - analogs & derivatives</subject><subject>Phencyclidine - toxicity</subject><subject>Receptors, N-Methyl-D-Aspartate</subject><subject>Receptors, Neurotransmitter - drug effects</subject><subject>Seizures - chemically induced</subject><subject>Time Factors</subject><subject>Toxicity: nervous system and muscle</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVISB03b5DAHkJpwdtKK-1KuhSKSZNAkubQnIU8mo1V1itX2g24T185Nj7mNPDPN8PMR8gFo18ZZc03SpkoK631Z6W_aCoVL9URmTAldUklq47J5IB8IGcp_aGU1rqqT8lpVQuVuQl5fMDBrpd-mBW2L3wKw9IH2NjeDpgT24WXIrTF0_xpVvjejYCpsKPz4QV7D0VC_2-MOfN9sfKAH8lJa7uE5_s6Jc8_r3_Pb8v7Xzd38x_3JQgmhxI4dwtAqYSsnbCMUpVvE42WHLhuWQM5QqkbxIVSCiXggivnWN1yJ6TjU_Jpt3cdw98R02BWPgF2ne0xjMmwmtdNJVQGxQ6EGFKK2Jp19CsbN4ZRs9Voto7M1pFR2rxpNNuxy_3-cbFCdxjae8v9q33fJrBdG20PPh2wRjb5zzpj33cYZhevHqNJ4LEHdD4iDMYF__4d_wEJOY16</recordid><startdate>19890608</startdate><enddate>19890608</enddate><creator>Debler, Edmund A.</creator><creator>Lipovac, Milo N.</creator><creator>Lajtha, Abel</creator><creator>Zlokovic, Berislav V.</creator><creator>Jacobson, Arthur E.</creator><creator>Rice, Kenner C.</creator><creator>Reith, Maarten E.A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19890608</creationdate><title>Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice</title><author>Debler, Edmund A. ; Lipovac, Milo N. ; Lajtha, Abel ; Zlokovic, Berislav V. ; Jacobson, Arthur E. ; Rice, Kenner C. ; Reith, Maarten E.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c33dbce78475d4a100800046973c39f16c100e796eeb888e7ceb38dd15f3d47d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Audiogenic seizures</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Injections</topic><topic>Injections, Intravenous</topic><topic>Medical sciences</topic><topic>Metaphit</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>N-Methyl-D-aspartate (NMDA)</topic><topic>Orbit</topic><topic>Pharmacology. Drug treatments</topic><topic>Phencyclidine (PCP)</topic><topic>Phencyclidine - analogs & derivatives</topic><topic>Phencyclidine - toxicity</topic><topic>Receptors, N-Methyl-D-Aspartate</topic><topic>Receptors, Neurotransmitter - drug effects</topic><topic>Seizures - chemically induced</topic><topic>Time Factors</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Debler, Edmund A.</creatorcontrib><creatorcontrib>Lipovac, Milo N.</creatorcontrib><creatorcontrib>Lajtha, Abel</creatorcontrib><creatorcontrib>Zlokovic, Berislav V.</creatorcontrib><creatorcontrib>Jacobson, Arthur E.</creatorcontrib><creatorcontrib>Rice, Kenner C.</creatorcontrib><creatorcontrib>Reith, Maarten E.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Debler, Edmund A.</au><au>Lipovac, Milo N.</au><au>Lajtha, Abel</au><au>Zlokovic, Berislav V.</au><au>Jacobson, Arthur E.</au><au>Rice, Kenner C.</au><au>Reith, Maarten E.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1989-06-08</date><risdate>1989</risdate><volume>165</volume><issue>1</issue><spage>155</spage><epage>159</epage><pages>155-159</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Metaphit induces audiogenic seizures in mice. The most severe clonic/tonic seizures occur 18–24 h after metaphit administration. After 48 h the incidence of the seizure episodes begin to diminish. These audiogenic seizures can be prevented by the administration of either PCP or MK-801 24 h after metaphit and 30 min prior to audio stimulation. These seizures may be due to a modulation of the PCP recognition site by metaphit which results in an enhanced probability that the NMDA/PCP ion channels are open.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2548879</pmid><doi>10.1016/0014-2999(89)90783-8</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1989-06, Vol.165 (1), p.155-159 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acoustic Stimulation Animals Audiogenic seizures Biological and medical sciences Drug toxicity and drugs side effects treatment Injections Injections, Intravenous Medical sciences Metaphit Mice Mice, Inbred BALB C N-Methyl-D-aspartate (NMDA) Orbit Pharmacology. Drug treatments Phencyclidine (PCP) Phencyclidine - analogs & derivatives Phencyclidine - toxicity Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - drug effects Seizures - chemically induced Time Factors Toxicity: nervous system and muscle |
| title | Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice |
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