Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening

In voltage-gated K + channels, membrane depolarization induces an upward movement of the voltage-sensing domains (VSD) that triggers pore opening. KCNQ1 is a voltage-gated K + channel and its gating behaviour is substantially modulated by auxiliary subunit KCNE proteins. KCNE1, for example, markedly...

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Veröffentlicht in:	Nature communications 2014-06, Vol.5 (1), p.4100-4100, Article 4100
Hauptverfasser:	Nakajo, Koichi, Kubo, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	14/34 631/45/269/1151 631/45/535 Amino Acid Motifs Cell Membrane - chemistry Cell Membrane - genetics Cell Membrane - metabolism Humanities and Social Sciences Humans KCNQ1 Potassium Channel - chemistry KCNQ1 Potassium Channel - genetics KCNQ1 Potassium Channel - metabolism Models, Molecular multidisciplinary Phenylalanine - genetics Phenylalanine - metabolism Potassium Channels, Voltage-Gated - chemistry Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism Science Science (multidisciplinary)
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