TIS gene expression in cultured rat astrocytes: Induction by mitogens and stellation agents
The expression of a number of TIS genes (Lim et al.:Oncogene 1:263–270, 1987) was examined in secondary cultures of rat neocortical astrocytes treated with mitogens and stellation agents, to study the early nuclear events which accompany the induction of glial proliferation and/or differentiation. T...
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| Veröffentlicht in: | Journal of neuroscience research 1989-07, Vol.23 (3), p.247-256 |
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| container_title | Journal of neuroscience research |
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| creator | Arenander, A. T. Lim, R. W. Varnum, B. C. Cole, R. de Vellis, J. Herschman, H. R. |
| description | The expression of a number of TIS genes (Lim et al.:Oncogene 1:263–270, 1987) was examined in secondary cultures of rat neocortical astrocytes treated with mitogens and stellation agents, to study the early nuclear events which accompany the induction of glial proliferation and/or differentiation. Tetradecanoyl phorbol acetate (TPA), epidermal growth factor, and firoblast growth factor, three mitogens for astrocytes, stimulated marked, rapid, and transient increases in TIS gene mRNAS. TIS10, which is not expressed in rat PC12 pheochromocytoma cells, could be induced by these mitogens in rat astrocytes. Dibutyryl cyclic adenosine monophosphate and forskolin, which induce rapid stellation in astrocytes, and ganglioside GM1, a potent mitogen as well as an antagonist of the induction and maintenance of stellation, all induced TIS gene expression. Thus, a broad range of agents which elicit both proliferative and differentiation responses in astrocytes are capable of inducing a family of genes that may play a role in the early events of signal transduction. |
| doi_str_mv | 10.1002/jnr.490230302 |
| format | Article |
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T. ; Lim, R. W. ; Varnum, B. C. ; Cole, R. ; de Vellis, J. ; Herschman, H. R.</creator><creatorcontrib>Arenander, A. T. ; Lim, R. W. ; Varnum, B. C. ; Cole, R. ; de Vellis, J. ; Herschman, H. R.</creatorcontrib><description>The expression of a number of TIS genes (Lim et al.:Oncogene 1:263–270, 1987) was examined in secondary cultures of rat neocortical astrocytes treated with mitogens and stellation agents, to study the early nuclear events which accompany the induction of glial proliferation and/or differentiation. Tetradecanoyl phorbol acetate (TPA), epidermal growth factor, and firoblast growth factor, three mitogens for astrocytes, stimulated marked, rapid, and transient increases in TIS gene mRNAS. TIS10, which is not expressed in rat PC12 pheochromocytoma cells, could be induced by these mitogens in rat astrocytes. Dibutyryl cyclic adenosine monophosphate and forskolin, which induce rapid stellation in astrocytes, and ganglioside GM1, a potent mitogen as well as an antagonist of the induction and maintenance of stellation, all induced TIS gene expression. Thus, a broad range of agents which elicit both proliferative and differentiation responses in astrocytes are capable of inducing a family of genes that may play a role in the early events of signal transduction.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.490230302</identifier><identifier>PMID: 2549263</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; astrocytes ; Astrocytes - cytology ; Astrocytes - drug effects ; Astrocytes - metabolism ; Cell Differentiation - drug effects ; Cell Division - drug effects ; Cells, Cultured ; Cerebral Cortex - cytology ; Cyclic AMP - metabolism ; Cyclic AMP - pharmacology ; ganglioside GM1 ; Gene Expression Regulation - drug effects ; growth factors ; Growth Substances - pharmacology ; Mitogens - pharmacology ; proliferation ; Rats ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; stellation ; Tetradecanoylphorbol Acetate - pharmacology ; TPA</subject><ispartof>Journal of neuroscience research, 1989-07, Vol.23 (3), p.247-256</ispartof><rights>Copyright © 1989 Alan R. Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-e238a5c57ebdee2ec414580664a7565cd3a20e54b91a0d373d5edb450bdfceb33</citedby><cites>FETCH-LOGICAL-c4052-e238a5c57ebdee2ec414580664a7565cd3a20e54b91a0d373d5edb450bdfceb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.490230302$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.490230302$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2549263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arenander, A. T.</creatorcontrib><creatorcontrib>Lim, R. W.</creatorcontrib><creatorcontrib>Varnum, B. C.</creatorcontrib><creatorcontrib>Cole, R.</creatorcontrib><creatorcontrib>de Vellis, J.</creatorcontrib><creatorcontrib>Herschman, H. R.</creatorcontrib><title>TIS gene expression in cultured rat astrocytes: Induction by mitogens and stellation agents</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>The expression of a number of TIS genes (Lim et al.:Oncogene 1:263–270, 1987) was examined in secondary cultures of rat neocortical astrocytes treated with mitogens and stellation agents, to study the early nuclear events which accompany the induction of glial proliferation and/or differentiation. Tetradecanoyl phorbol acetate (TPA), epidermal growth factor, and firoblast growth factor, three mitogens for astrocytes, stimulated marked, rapid, and transient increases in TIS gene mRNAS. TIS10, which is not expressed in rat PC12 pheochromocytoma cells, could be induced by these mitogens in rat astrocytes. Dibutyryl cyclic adenosine monophosphate and forskolin, which induce rapid stellation in astrocytes, and ganglioside GM1, a potent mitogen as well as an antagonist of the induction and maintenance of stellation, all induced TIS gene expression. Thus, a broad range of agents which elicit both proliferative and differentiation responses in astrocytes are capable of inducing a family of genes that may play a role in the early events of signal transduction.</description><subject>Animals</subject><subject>astrocytes</subject><subject>Astrocytes - cytology</subject><subject>Astrocytes - drug effects</subject><subject>Astrocytes - metabolism</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Cerebral Cortex - cytology</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP - pharmacology</subject><subject>ganglioside GM1</subject><subject>Gene Expression Regulation - drug effects</subject><subject>growth factors</subject><subject>Growth Substances - pharmacology</subject><subject>Mitogens - pharmacology</subject><subject>proliferation</subject><subject>Rats</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>stellation</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>TPA</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P20AQhldVEQ3QI8dKe-rNYby7Y8fcqgiS8BEQpapUDqv17gSZOnbYXavk39chUdRTTyPN-8yr0cPYaQrDFECcvTR-qAoQEiSID2yQQpEnClX-kQ1AZpAoSMUndhTCCwAUBcpDdihQFSKTA_b0OPvOn6khTm8rTyFUbcOrhtuujp0nx72J3IToW7uOFM75rHGdjRuqXPNlFdv-OHDTOB4i1bV5j0y_jOGEHSxMHejzbh6zH5cXj-NpcnM3mY2_3SRWAYqEhBwZtJhT6YgEWZUqHEGWKZNjhtZJI4BQlUVqwMlcOiRXKoTSLSyVUh6zr9velW9fOwpRL6tgN8801HZBpygRRxJ7MNmC1rcheFrola-Wxq91CnojU_cy9V5mz3_ZFXflktye3tnr83yb_6lqWv-_TF_NH_5t3n1S9dbe9pfG_9ZZLnPUP-cTfT29ula_1K2-l38Bt6-QiQ</recordid><startdate>198907</startdate><enddate>198907</enddate><creator>Arenander, A. T.</creator><creator>Lim, R. W.</creator><creator>Varnum, B. C.</creator><creator>Cole, R.</creator><creator>de Vellis, J.</creator><creator>Herschman, H. R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>198907</creationdate><title>TIS gene expression in cultured rat astrocytes: Induction by mitogens and stellation agents</title><author>Arenander, A. T. ; Lim, R. W. ; Varnum, B. C. ; Cole, R. ; de Vellis, J. ; Herschman, H. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-e238a5c57ebdee2ec414580664a7565cd3a20e54b91a0d373d5edb450bdfceb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>astrocytes</topic><topic>Astrocytes - cytology</topic><topic>Astrocytes - drug effects</topic><topic>Astrocytes - metabolism</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Cerebral Cortex - cytology</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP - pharmacology</topic><topic>ganglioside GM1</topic><topic>Gene Expression Regulation - drug effects</topic><topic>growth factors</topic><topic>Growth Substances - pharmacology</topic><topic>Mitogens - pharmacology</topic><topic>proliferation</topic><topic>Rats</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>stellation</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>TPA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arenander, A. T.</creatorcontrib><creatorcontrib>Lim, R. W.</creatorcontrib><creatorcontrib>Varnum, B. C.</creatorcontrib><creatorcontrib>Cole, R.</creatorcontrib><creatorcontrib>de Vellis, J.</creatorcontrib><creatorcontrib>Herschman, H. R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arenander, A. T.</au><au>Lim, R. W.</au><au>Varnum, B. C.</au><au>Cole, R.</au><au>de Vellis, J.</au><au>Herschman, H. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TIS gene expression in cultured rat astrocytes: Induction by mitogens and stellation agents</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>1989-07</date><risdate>1989</risdate><volume>23</volume><issue>3</issue><spage>247</spage><epage>256</epage><pages>247-256</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>The expression of a number of TIS genes (Lim et al.:Oncogene 1:263–270, 1987) was examined in secondary cultures of rat neocortical astrocytes treated with mitogens and stellation agents, to study the early nuclear events which accompany the induction of glial proliferation and/or differentiation. Tetradecanoyl phorbol acetate (TPA), epidermal growth factor, and firoblast growth factor, three mitogens for astrocytes, stimulated marked, rapid, and transient increases in TIS gene mRNAS. 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| subjects | Animals astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Cell Differentiation - drug effects Cell Division - drug effects Cells, Cultured Cerebral Cortex - cytology Cyclic AMP - metabolism Cyclic AMP - pharmacology ganglioside GM1 Gene Expression Regulation - drug effects growth factors Growth Substances - pharmacology Mitogens - pharmacology proliferation Rats RNA, Messenger - genetics RNA, Messenger - metabolism stellation Tetradecanoylphorbol Acetate - pharmacology TPA |
| title | TIS gene expression in cultured rat astrocytes: Induction by mitogens and stellation agents |
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