Cited2 is required in trophoblasts for correct placental capillary patterning

CITED2 is a transcriptional co-factor with important roles in many organs of the developing mammalian embryo. Complete deletion of this gene causes severe malformation of the placenta, and results in significantly reduced embryonic growth and death from E14.5. The placenta is a complex organ origina...

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Veröffentlicht in:	Developmental biology 2014-08, Vol.392 (1), p.62-79
Hauptverfasser:	Moreau, Julie L.M., Artap, Stanley T., Shi, Hongjun, Chapman, Gavin, Leone, Gustavo, Sparrow, Duncan B., Dunwoodie, Sally L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - biosynthesis Animals Body Patterning Capillaries - embryology Carrier Proteins - metabolism Cited2 Embryonic Development Female Gene Deletion Mice Mice, Inbred C57BL Monocarboxylic Acid Transporters - biosynthesis Mouse Muscle Proteins - biosynthesis Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology PDGF signaling Pericytes - cytology Pericytes - physiology Placenta Placenta - blood supply Placenta - embryology Placental Circulation - genetics Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism Pregnancy Proto-Oncogene Proteins c-sis - biosynthesis Receptor, Platelet-Derived Growth Factor beta - biosynthesis Repressor Proteins - genetics Symporters - biosynthesis Trans-Activators - genetics Trophoblast Trophoblasts - enzymology Vasculature
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