Comparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimeters
Colorectal flat adenomas (FAs) may represent a different histogenesis, since their malignant potential is thought to be higher than polypoid adenomas of the same size. In this study, we classified FAs of ≤5 mm into three subgroups-superficially elevated adenomas (SEAs), completely flat adenomas (CFA...
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| Veröffentlicht in: | The Turkish journal of gastroenterology 2014-02, Vol.25 (1), p.24-28 |
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| creator | Yener, Neşe Arzu Midi, Ahmet Ataizi Çelikel, Ciğdem |
| description | Colorectal flat adenomas (FAs) may represent a different histogenesis, since their malignant potential is thought to be higher than polypoid adenomas of the same size. In this study, we classified FAs of ≤5 mm into three subgroups-superficially elevated adenomas (SEAs), completely flat adenomas (CFAs), and depressed adenomas (DAs)-based on their low microscopic shapes and compared their clinicopathological features with polypoid tubular adenomas (pTAs) with the same size.
One hundred one pTAs and 46 FAs with tubular morphology with the same size (≤5 mm) were studied.
The percentages of high-grade dysplasia in FAs and pTAs were 19.56% and 12.87%, respectively. The percentages of the high-grade dysplasia were 28.57%, 13.63%, and 20.00% in the DA, SEA, and CFA subgroups, respectively. FAs had a significantly higher number of normal epithelium at the basal crypts of the lesion than the pTAs (p=0.001). The presence of pericryptal mesenchymal cells was higher in pTAs than the FAs (78.21% vs 10.86%) (p |
| doi_str_mv | 10.5152/tjg.2014.2698 |
| format | Article |
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One hundred one pTAs and 46 FAs with tubular morphology with the same size (≤5 mm) were studied.
The percentages of high-grade dysplasia in FAs and pTAs were 19.56% and 12.87%, respectively. The percentages of the high-grade dysplasia were 28.57%, 13.63%, and 20.00% in the DA, SEA, and CFA subgroups, respectively. FAs had a significantly higher number of normal epithelium at the basal crypts of the lesion than the pTAs (p=0.001). The presence of pericryptal mesenchymal cells was higher in pTAs than the FAs (78.21% vs 10.86%) (p<0.001).
Flat adenoma represents a distinct type of colorectal adenoma with special histopathological properties-existence of a normal epithelium at the basal crypts, lack of pericryptal mesenchymal cells, and a high percentage of high-grade dysplasia-especially when it has a depressed shape at low magnification.</description><identifier>ISSN: 1300-4948</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.5152/tjg.2014.2698</identifier><identifier>PMID: 24918126</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adenoma - pathology ; Adenoma - surgery ; Adult ; Aged ; Carcinogenesis - pathology ; Colonoscopy ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Humans ; Intestinal Mucosa - pathology ; Intestinal Mucosa - surgery ; Male ; Middle Aged ; Retrospective Studies</subject><ispartof>The Turkish journal of gastroenterology, 2014-02, Vol.25 (1), p.24-28</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24918126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yener, Neşe Arzu</creatorcontrib><creatorcontrib>Midi, Ahmet</creatorcontrib><creatorcontrib>Ataizi Çelikel, Ciğdem</creatorcontrib><title>Comparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimeters</title><title>The Turkish journal of gastroenterology</title><addtitle>Turk J Gastroenterol</addtitle><description>Colorectal flat adenomas (FAs) may represent a different histogenesis, since their malignant potential is thought to be higher than polypoid adenomas of the same size. In this study, we classified FAs of ≤5 mm into three subgroups-superficially elevated adenomas (SEAs), completely flat adenomas (CFAs), and depressed adenomas (DAs)-based on their low microscopic shapes and compared their clinicopathological features with polypoid tubular adenomas (pTAs) with the same size.
One hundred one pTAs and 46 FAs with tubular morphology with the same size (≤5 mm) were studied.
The percentages of high-grade dysplasia in FAs and pTAs were 19.56% and 12.87%, respectively. The percentages of the high-grade dysplasia were 28.57%, 13.63%, and 20.00% in the DA, SEA, and CFA subgroups, respectively. FAs had a significantly higher number of normal epithelium at the basal crypts of the lesion than the pTAs (p=0.001). The presence of pericryptal mesenchymal cells was higher in pTAs than the FAs (78.21% vs 10.86%) (p<0.001).
Flat adenoma represents a distinct type of colorectal adenoma with special histopathological properties-existence of a normal epithelium at the basal crypts, lack of pericryptal mesenchymal cells, and a high percentage of high-grade dysplasia-especially when it has a depressed shape at low magnification.</description><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Carcinogenesis - pathology</subject><subject>Colonoscopy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><issn>1300-4948</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E9PwyAcxnFiNDqnR6-Go5dOoJTRo1n8lyzxoueG0R8bhpYOqMnegq9amqnhQEI-eUi-CN1Qsqhoxe7T53bBCOULJmp5gmaMcllUgixP0YyWhBS85vICXcb4SUgpqWDn6ILxmkrKxAx9r3w3qGCj77E3OO0Aa2d7q_2g0s47v7VaOWxApTFAnIxxKmHVt3jw7jB422KdXQCdMlQt9L5TMS9NKgCOnXIOwvSQvwgY9mN2yWNjvwB31jnbQYIQr9CZUS7C9e89Rx9Pj--rl2L99vy6elgXmkmZiqoSwhiyyQeUVGQJijEwxNScSa1pyXW7NFoILogkFErgFTXLmm02tZFclnN0d9wdgt-PEFPT2ajBOdWDH2NDq7JiRDJBMi2OVAcfYwDTDMF2KhwaSpopf5PzN1P-Zsqf_e3v9LjpoP3Xf73LH40Og5s</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Yener, Neşe Arzu</creator><creator>Midi, Ahmet</creator><creator>Ataizi Çelikel, Ciğdem</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Comparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimeters</title><author>Yener, Neşe Arzu ; Midi, Ahmet ; Ataizi Çelikel, Ciğdem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-5566ff0b0b0ea8a07ea22ef0f9428cc134cd7fc66460801e3e451f792bb9f8483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Carcinogenesis - pathology</topic><topic>Colonoscopy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yener, Neşe Arzu</creatorcontrib><creatorcontrib>Midi, Ahmet</creatorcontrib><creatorcontrib>Ataizi Çelikel, Ciğdem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Turkish journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yener, Neşe Arzu</au><au>Midi, Ahmet</au><au>Ataizi Çelikel, Ciğdem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimeters</atitle><jtitle>The Turkish journal of gastroenterology</jtitle><addtitle>Turk J Gastroenterol</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>25</volume><issue>1</issue><spage>24</spage><epage>28</epage><pages>24-28</pages><issn>1300-4948</issn><eissn>2148-5607</eissn><abstract>Colorectal flat adenomas (FAs) may represent a different histogenesis, since their malignant potential is thought to be higher than polypoid adenomas of the same size. In this study, we classified FAs of ≤5 mm into three subgroups-superficially elevated adenomas (SEAs), completely flat adenomas (CFAs), and depressed adenomas (DAs)-based on their low microscopic shapes and compared their clinicopathological features with polypoid tubular adenomas (pTAs) with the same size.
One hundred one pTAs and 46 FAs with tubular morphology with the same size (≤5 mm) were studied.
The percentages of high-grade dysplasia in FAs and pTAs were 19.56% and 12.87%, respectively. The percentages of the high-grade dysplasia were 28.57%, 13.63%, and 20.00% in the DA, SEA, and CFA subgroups, respectively. FAs had a significantly higher number of normal epithelium at the basal crypts of the lesion than the pTAs (p=0.001). The presence of pericryptal mesenchymal cells was higher in pTAs than the FAs (78.21% vs 10.86%) (p<0.001).
Flat adenoma represents a distinct type of colorectal adenoma with special histopathological properties-existence of a normal epithelium at the basal crypts, lack of pericryptal mesenchymal cells, and a high percentage of high-grade dysplasia-especially when it has a depressed shape at low magnification.</abstract><cop>Turkey</cop><pmid>24918126</pmid><doi>10.5152/tjg.2014.2698</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Adenoma - pathology Adenoma - surgery Adult Aged Carcinogenesis - pathology Colonoscopy Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Humans Intestinal Mucosa - pathology Intestinal Mucosa - surgery Male Middle Aged Retrospective Studies |
| title | Comparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimeters |
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