Histopathologic lens changes in mirex-exposed rats
The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling o...
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| Veröffentlicht in: | Toxicology letters 1981-01, Vol.9 (3), p.289-294 |
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| container_title | Toxicology letters |
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| creator | Scotti, Thomas M. Chernoff, Neil Linder, Ralph Mcelroy, W.Keith |
| description | The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of individual cortical lens fibers. At day 9, many swollen but intact fibers were observed, and at days 11 and 13, extensive degeneration and necrosis appeared throughout the cortex of the affected lenses. |
| doi_str_mv | 10.1016/0378-4274(81)90163-6 |
| format | Article |
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The earliest histologic change, seen at neonatal day 7, was slight swelling of individual cortical lens fibers. At day 9, many swollen but intact fibers were observed, and at days 11 and 13, extensive degeneration and necrosis appeared throughout the cortex of the affected lenses.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(81)90163-6</identifier><identifier>PMID: 7198310</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>agrochemicals ; animal health ; animal injuries ; Animals ; Animals, Newborn ; Cataract - chemically induced ; Cataract - pathology ; Female ; Insecticides - toxicity ; Lactation ; Lens, Crystalline - drug effects ; Lens, Crystalline - pathology ; Mirex - toxicity ; pesticides ; Pregnancy ; Rats</subject><ispartof>Toxicology letters, 1981-01, Vol.9 (3), p.289-294</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-e5b81c1e04575f9a67f3ae58cda3949e0a89a04f44f34a24bda43a7ae66fa5f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(81)90163-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7198310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scotti, Thomas M.</creatorcontrib><creatorcontrib>Chernoff, Neil</creatorcontrib><creatorcontrib>Linder, Ralph</creatorcontrib><creatorcontrib>Mcelroy, W.Keith</creatorcontrib><title>Histopathologic lens changes in mirex-exposed rats</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. 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At day 9, many swollen but intact fibers were observed, and at days 11 and 13, extensive degeneration and necrosis appeared throughout the cortex of the affected lenses.</description><subject>agrochemicals</subject><subject>animal health</subject><subject>animal injuries</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cataract - chemically induced</subject><subject>Cataract - pathology</subject><subject>Female</subject><subject>Insecticides - toxicity</subject><subject>Lactation</subject><subject>Lens, Crystalline - drug effects</subject><subject>Lens, Crystalline - pathology</subject><subject>Mirex - toxicity</subject><subject>pesticides</subject><subject>Pregnancy</subject><subject>Rats</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJSJ20_6CheyrpYVPN6mOlS6CYtAkYcmhzFmPtyFFYrxxpXZJ_n3VtcgwMDMz7zDA8jH0Bfgkc9A8uWlPLppUXBr7baSJq_YHNwLS2FqDtEZu9IR_ZaSmPnHMttTphJy1YI4DPWHMTy5g2OD6kPq2ir3oaSuUfcFhRqeJQrWOm55qeN6lQV2Ucyyd2HLAv9PnQz9j9r-u_85t6cff7dv5zUXsJzViTWhrwQFyqVgWLug0CSRnfobDSEkdjkcsgZRASG7nsUApskbQOqIISZ-zb_u4mp6ctldGtY_HU9zhQ2hYHSkgLXE6g3IM-p1IyBbfJcY35xQF3O1Vu58HtPDgD7r8qp6e188P97XJN3dvSwc2Uf93nAZPDVY7F3f9pOIiphFBgJuJqT9Ck4V-k7IqPNHjqJml-dF2K77_wCtshgNc</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Scotti, Thomas M.</creator><creator>Chernoff, Neil</creator><creator>Linder, Ralph</creator><creator>Mcelroy, W.Keith</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19810101</creationdate><title>Histopathologic lens changes in mirex-exposed rats</title><author>Scotti, Thomas M. ; Chernoff, Neil ; Linder, Ralph ; Mcelroy, W.Keith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-e5b81c1e04575f9a67f3ae58cda3949e0a89a04f44f34a24bda43a7ae66fa5f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>agrochemicals</topic><topic>animal health</topic><topic>animal injuries</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Cataract - chemically induced</topic><topic>Cataract - pathology</topic><topic>Female</topic><topic>Insecticides - toxicity</topic><topic>Lactation</topic><topic>Lens, Crystalline - drug effects</topic><topic>Lens, Crystalline - pathology</topic><topic>Mirex - toxicity</topic><topic>pesticides</topic><topic>Pregnancy</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scotti, Thomas M.</creatorcontrib><creatorcontrib>Chernoff, Neil</creatorcontrib><creatorcontrib>Linder, Ralph</creatorcontrib><creatorcontrib>Mcelroy, W.Keith</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scotti, Thomas M.</au><au>Chernoff, Neil</au><au>Linder, Ralph</au><au>Mcelroy, W.Keith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathologic lens changes in mirex-exposed rats</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>9</volume><issue>3</issue><spage>289</spage><epage>294</epage><pages>289-294</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. 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| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1981-01, Vol.9 (3), p.289-294 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15349104 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | agrochemicals animal health animal injuries Animals Animals, Newborn Cataract - chemically induced Cataract - pathology Female Insecticides - toxicity Lactation Lens, Crystalline - drug effects Lens, Crystalline - pathology Mirex - toxicity pesticides Pregnancy Rats |
| title | Histopathologic lens changes in mirex-exposed rats |
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