Leishmanicidal Triterpenes from Lantana camara
Two new natural triterpenes, lantaninilic acid and lantoic acid, along with the known triterpenes lantadene A, and oleanolic, ursolic, betulinic, lantanolic, and camaric acid, were obtained from the aerial parts of Lantana camara through bioassay‐guided isolation, monitoring the in vitro antileishma...
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| Veröffentlicht in: | Chemistry & biodiversity 2014-05, Vol.11 (5), p.709-718 |
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| creator | Begum, Sabira Ayub, Anjum Qamar Zehra, Syeda Shaheen Siddiqui, Bina Iqbal Choudhary, M. Samreen |
| description | Two new natural triterpenes, lantaninilic acid and lantoic acid, along with the known triterpenes lantadene A, and oleanolic, ursolic, betulinic, lantanolic, and camaric acid, were obtained from the aerial parts of Lantana camara through bioassay‐guided isolation, monitoring the in vitro antileishmanial activity against promastigotes of Leishmania major. Oleanolic acid (3), ursolic acid (4), lantadene A (5), and lantanilic acid (7) showed significant leishmanicidal activities with IC50 values of 53.0, 12.4, 20.4, and 21.3 μM, respectively. The IC50 value of ursolic acid (4; 12.4 μM) was found to be comparable with that of the standard drugs, pentamidine (IC50 15.0 μM) and amphotericin B (IC50 0.31 μM). The in vitro activities of L. camara and its constituents against promastigotes of Leishmania major are reported here for the first time. |
| doi_str_mv | 10.1002/cbdv.201300151 |
| format | Article |
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Oleanolic acid (3), ursolic acid (4), lantadene A (5), and lantanilic acid (7) showed significant leishmanicidal activities with IC50 values of 53.0, 12.4, 20.4, and 21.3 μM, respectively. The IC50 value of ursolic acid (4; 12.4 μM) was found to be comparable with that of the standard drugs, pentamidine (IC50 15.0 μM) and amphotericin B (IC50 0.31 μM). The in vitro activities of L. camara and its constituents against promastigotes of Leishmania major are reported here for the first time.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.201300151</identifier><identifier>PMID: 24827681</identifier><language>eng</language><publisher>Zürich: WILEY-VCH Verlag</publisher><subject>Humans ; Lantana - chemistry ; Lantana camara ; Lantaninilic acid ; Lantoic acid ; Leishmania major ; Leishmania major - drug effects ; Leishmaniasis, Cutaneous - drug therapy ; Leishmanicidal activity ; Plant Leaves - chemistry ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; Triterpenoids ; Trypanocidal Agents - chemistry ; Trypanocidal Agents - isolation & purification ; Trypanocidal Agents - pharmacology</subject><ispartof>Chemistry & biodiversity, 2014-05, Vol.11 (5), p.709-718</ispartof><rights>Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich</rights><rights>Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.</rights><rights>Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zurich</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4441-409cc44d84b0d4597aced3b2f6a0181b6694d8bc7f6ab405f258ce37b5579d813</citedby><cites>FETCH-LOGICAL-c4441-409cc44d84b0d4597aced3b2f6a0181b6694d8bc7f6ab405f258ce37b5579d813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.201300151$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.201300151$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24827681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Begum, Sabira</creatorcontrib><creatorcontrib>Ayub, Anjum</creatorcontrib><creatorcontrib>Qamar Zehra, Syeda</creatorcontrib><creatorcontrib>Shaheen Siddiqui, Bina</creatorcontrib><creatorcontrib>Iqbal Choudhary, M.</creatorcontrib><creatorcontrib>Samreen</creatorcontrib><title>Leishmanicidal Triterpenes from Lantana camara</title><title>Chemistry & biodiversity</title><addtitle>Chemistry & Biodiversity</addtitle><description>Two new natural triterpenes, lantaninilic acid and lantoic acid, along with the known triterpenes lantadene A, and oleanolic, ursolic, betulinic, lantanolic, and camaric acid, were obtained from the aerial parts of Lantana camara through bioassay‐guided isolation, monitoring the in vitro antileishmanial activity against promastigotes of Leishmania major. Oleanolic acid (3), ursolic acid (4), lantadene A (5), and lantanilic acid (7) showed significant leishmanicidal activities with IC50 values of 53.0, 12.4, 20.4, and 21.3 μM, respectively. The IC50 value of ursolic acid (4; 12.4 μM) was found to be comparable with that of the standard drugs, pentamidine (IC50 15.0 μM) and amphotericin B (IC50 0.31 μM). The in vitro activities of L. camara and its constituents against promastigotes of Leishmania major are reported here for the first time.</description><subject>Humans</subject><subject>Lantana - chemistry</subject><subject>Lantana camara</subject><subject>Lantaninilic acid</subject><subject>Lantoic acid</subject><subject>Leishmania major</subject><subject>Leishmania major - drug effects</subject><subject>Leishmaniasis, Cutaneous - drug therapy</subject><subject>Leishmanicidal activity</subject><subject>Plant Leaves - chemistry</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>Triterpenoids</subject><subject>Trypanocidal Agents - chemistry</subject><subject>Trypanocidal Agents - isolation & purification</subject><subject>Trypanocidal Agents - pharmacology</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1LwzAYh4MoTqdXj1Lw4qUzSfPVo246haI45jyGNE2xsx8zWdX992ZsFvGip7y8eX4PvD8AThAcIAjxhU6z9wGGKIIQUbQDDhBDOERCwN1u5rgHDp2be97vxT7oYSIwZwIdgEFiCvdSqbrQRabKYGqLpbELUxsX5LapgkTVS1WrQKtKWXUE9nJVOnO8ffvg6eZ6OrwNk4fx3fAyCTUhBIUExtpPmSApzAiNudImi1KcMwWRQCljsf9MNfeLlECaYyq0iXhKKY8zgaI-ON94F7Z5a41byqpw2pSlqk3TOoloRATlkLJ_oJhyxjFfW89-ofOmtbU_ZE0RFHHIqacGG0rbxjlrcrmwhT9-JRGU69LlunTZle4Dp1ttm1Ym6_Dvlj0Qb4CPojSrP3RyeDWa_ZSHm2zhluazyyr7KhmPOJXP92M5mz4mIzIRchJ9AfWYmlU</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Begum, Sabira</creator><creator>Ayub, Anjum</creator><creator>Qamar Zehra, Syeda</creator><creator>Shaheen Siddiqui, Bina</creator><creator>Iqbal Choudhary, M.</creator><creator>Samreen</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7ST</scope><scope>7U6</scope><scope>C1K</scope></search><sort><creationdate>201405</creationdate><title>Leishmanicidal Triterpenes from Lantana camara</title><author>Begum, Sabira ; Ayub, Anjum ; Qamar Zehra, Syeda ; Shaheen Siddiqui, Bina ; Iqbal Choudhary, M. ; Samreen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4441-409cc44d84b0d4597aced3b2f6a0181b6694d8bc7f6ab405f258ce37b5579d813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Humans</topic><topic>Lantana - chemistry</topic><topic>Lantana camara</topic><topic>Lantaninilic acid</topic><topic>Lantoic acid</topic><topic>Leishmania major</topic><topic>Leishmania major - drug effects</topic><topic>Leishmaniasis, Cutaneous - drug therapy</topic><topic>Leishmanicidal activity</topic><topic>Plant Leaves - chemistry</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>Triterpenoids</topic><topic>Trypanocidal Agents - chemistry</topic><topic>Trypanocidal Agents - isolation & purification</topic><topic>Trypanocidal Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begum, Sabira</creatorcontrib><creatorcontrib>Ayub, Anjum</creatorcontrib><creatorcontrib>Qamar Zehra, Syeda</creatorcontrib><creatorcontrib>Shaheen Siddiqui, Bina</creatorcontrib><creatorcontrib>Iqbal Choudhary, M.</creatorcontrib><creatorcontrib>Samreen</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Sustainability Science Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begum, Sabira</au><au>Ayub, Anjum</au><au>Qamar Zehra, Syeda</au><au>Shaheen Siddiqui, Bina</au><au>Iqbal Choudhary, M.</au><au>Samreen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leishmanicidal Triterpenes from Lantana camara</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chemistry & Biodiversity</addtitle><date>2014-05</date><risdate>2014</risdate><volume>11</volume><issue>5</issue><spage>709</spage><epage>718</epage><pages>709-718</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>Two new natural triterpenes, lantaninilic acid and lantoic acid, along with the known triterpenes lantadene A, and oleanolic, ursolic, betulinic, lantanolic, and camaric acid, were obtained from the aerial parts of Lantana camara through bioassay‐guided isolation, monitoring the in vitro antileishmanial activity against promastigotes of Leishmania major. Oleanolic acid (3), ursolic acid (4), lantadene A (5), and lantanilic acid (7) showed significant leishmanicidal activities with IC50 values of 53.0, 12.4, 20.4, and 21.3 μM, respectively. The IC50 value of ursolic acid (4; 12.4 μM) was found to be comparable with that of the standard drugs, pentamidine (IC50 15.0 μM) and amphotericin B (IC50 0.31 μM). The in vitro activities of L. camara and its constituents against promastigotes of Leishmania major are reported here for the first time.</abstract><cop>Zürich</cop><pub>WILEY-VCH Verlag</pub><pmid>24827681</pmid><doi>10.1002/cbdv.201300151</doi><tpages>10</tpages></addata></record> |
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| subjects | Humans Lantana - chemistry Lantana camara Lantaninilic acid Lantoic acid Leishmania major Leishmania major - drug effects Leishmaniasis, Cutaneous - drug therapy Leishmanicidal activity Plant Leaves - chemistry Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenoids Trypanocidal Agents - chemistry Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology |
| title | Leishmanicidal Triterpenes from Lantana camara |
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