Role of glutathione S-transferases in the spinocerebellar ataxia type 2 clinical phenotype

Abstract Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative and incurable hereditary disorder caused by a CAG repeat expansion mutation on ATXN2 gene. The identification of reliable biochemical markers of disease severity is of paramount significance for the development and assessment of cl...

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Veröffentlicht in:	Journal of the neurological sciences 2014-06, Vol.341 (1), p.41-45
Hauptverfasser:	Almaguer-Gotay, D, Almaguer-Mederos, L.E, Aguilera-Rodríguez, R, Estupiñán-Rodríguez, A, González-Zaldivar, Y, Cuello-Almarales, D, Laffita-Mesa, J.M, Vázquez-Mojena, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Analysis of Variance Antioxidant enzymes Ataxins Case-Control Studies Female Glutathione S-transferase Glutathione Transferase - blood Humans Male Middle Aged Nerve Tissue Proteins - genetics Neurology Oxidative stress Phenotype Polyglutamine disease Presymptomatic Sensitivity and Specificity Spinocerebellar ataxia type 2 Spinocerebellar Ataxias - enzymology Spinocerebellar Ataxias - genetics Trinucleotide Repeats - genetics Young Adult
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