Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive–compulsive disorder
Abstract Obsessive–compulsive disorder (OCD) has a typical onset during childhood or adolescence. Although recent in-vivo proton magnetic resonance spectroscopy (1 H-MRS) studies report gray matter metabolite abnormalities in children and adolescents with OCD, there are no existing1 H-MRS studies th...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2014-04, Vol.222 (1), p.67-74 |
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| creator | Weber, Alexander Mark Soreni, Noam Stanley, Jeffrey A Greco, Alessia Mendlowitz, Sandra Szatmari, Peter Schachar, Russell Mannasis, Katharina Pires, Paulo Swinson, Richard Noseworthy, Michael D |
| description | Abstract Obsessive–compulsive disorder (OCD) has a typical onset during childhood or adolescence. Although recent in-vivo proton magnetic resonance spectroscopy (1 H-MRS) studies report gray matter metabolite abnormalities in children and adolescents with OCD, there are no existing1 H-MRS studies that measure white matter (WM) metabolite levels in this population. In the present study, we measured metabolite levels in the left and right prefrontal WM (LPFWM and RPFWM, respectively) of psychotropic-naïve children and adolescents with OCD (LPFWM: N =15, mean age 13.3±2.4 years; right RPFWM: N =14, mean age 13.0±2.3 years) and healthy controls (LPFWM: N =17, mean age 11.8±2.7 years; RPFWM: N =18, mean age 12.2±2.8 years). Spectra were acquired using a 3T single voxel PRESS sequence (1.5×2.0×2.0 cm3 ). When age and sex effects were controlled, OCD patients had higher levels of RPFWM choline and N -acetyl-aspartate (NAA). In addition, RPFWM levels of NAA, creatine and myo-inositol were positively and significantly correlated with severity of OCD symptoms. In summary, this is the first published study of WM metabolite levels in children and adolescents with OCD. Our preliminary findings lend further support to the previous findings of WM abnormalities in OCD. |
| doi_str_mv | 10.1016/j.pscychresns.2014.02.004 |
| format | Article |
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Although recent in-vivo proton magnetic resonance spectroscopy (1 H-MRS) studies report gray matter metabolite abnormalities in children and adolescents with OCD, there are no existing1 H-MRS studies that measure white matter (WM) metabolite levels in this population. In the present study, we measured metabolite levels in the left and right prefrontal WM (LPFWM and RPFWM, respectively) of psychotropic-naïve children and adolescents with OCD (LPFWM: N =15, mean age 13.3±2.4 years; right RPFWM: N =14, mean age 13.0±2.3 years) and healthy controls (LPFWM: N =17, mean age 11.8±2.7 years; RPFWM: N =18, mean age 12.2±2.8 years). Spectra were acquired using a 3T single voxel PRESS sequence (1.5×2.0×2.0 cm3 ). When age and sex effects were controlled, OCD patients had higher levels of RPFWM choline and N -acetyl-aspartate (NAA). In addition, RPFWM levels of NAA, creatine and myo-inositol were positively and significantly correlated with severity of OCD symptoms. In summary, this is the first published study of WM metabolite levels in children and adolescents with OCD. Our preliminary findings lend further support to the previous findings of WM abnormalities in OCD.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2014.02.004</identifier><identifier>PMID: 24602517</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>1H-MRS ; Adolescent ; Adult and adolescent clinical studies ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Brain ; Child ; Choline - metabolism ; Creatine - metabolism ; Female ; Humans ; Inositol - metabolism ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Nerve Fibers, Myelinated - metabolism ; Neuroimaging ; Obsessive-Compulsive Disorder - metabolism ; Obsessive-compulsive disorders ; OCD ; Pediatric ; Psychiatry ; Psychology. Psychoanalysis. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-ea839ec32a2264081478729a7ef0a44ebbdcd3ec0ebd7f6b12024fa169e0eecc3</citedby><cites>FETCH-LOGICAL-c495t-ea839ec32a2264081478729a7ef0a44ebbdcd3ec0ebd7f6b12024fa169e0eecc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0925492714000316$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28422754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24602517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weber, Alexander Mark</creatorcontrib><creatorcontrib>Soreni, Noam</creatorcontrib><creatorcontrib>Stanley, Jeffrey A</creatorcontrib><creatorcontrib>Greco, Alessia</creatorcontrib><creatorcontrib>Mendlowitz, Sandra</creatorcontrib><creatorcontrib>Szatmari, Peter</creatorcontrib><creatorcontrib>Schachar, Russell</creatorcontrib><creatorcontrib>Mannasis, Katharina</creatorcontrib><creatorcontrib>Pires, Paulo</creatorcontrib><creatorcontrib>Swinson, Richard</creatorcontrib><creatorcontrib>Noseworthy, Michael D</creatorcontrib><title>Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive–compulsive disorder</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res</addtitle><description>Abstract Obsessive–compulsive disorder (OCD) has a typical onset during childhood or adolescence. Although recent in-vivo proton magnetic resonance spectroscopy (1 H-MRS) studies report gray matter metabolite abnormalities in children and adolescents with OCD, there are no existing1 H-MRS studies that measure white matter (WM) metabolite levels in this population. In the present study, we measured metabolite levels in the left and right prefrontal WM (LPFWM and RPFWM, respectively) of psychotropic-naïve children and adolescents with OCD (LPFWM: N =15, mean age 13.3±2.4 years; right RPFWM: N =14, mean age 13.0±2.3 years) and healthy controls (LPFWM: N =17, mean age 11.8±2.7 years; RPFWM: N =18, mean age 12.2±2.8 years). Spectra were acquired using a 3T single voxel PRESS sequence (1.5×2.0×2.0 cm3 ). When age and sex effects were controlled, OCD patients had higher levels of RPFWM choline and N -acetyl-aspartate (NAA). In addition, RPFWM levels of NAA, creatine and myo-inositol were positively and significantly correlated with severity of OCD symptoms. In summary, this is the first published study of WM metabolite levels in children and adolescents with OCD. Our preliminary findings lend further support to the previous findings of WM abnormalities in OCD.</description><subject>1H-MRS</subject><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Child</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Inositol - metabolism</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Fibers, Myelinated - metabolism</subject><subject>Neuroimaging</subject><subject>Obsessive-Compulsive Disorder - metabolism</subject><subject>Obsessive-compulsive disorders</subject><subject>OCD</subject><subject>Pediatric</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychotropic-naïve</subject><subject>Radiology</subject><subject>White matter</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktuKFDEQhhtR3HH1FSReCN7MWDn06UaQYT3AgoJ6HdLpaidjT9KmMrvMne8g-Bo-hG_ik5hmxgPeKARC4P__qtRXRfGAw4oDrx5vVxPZg91EJE8rAVytQKwA1I1iwZtaLOsSqpvFAlpRLlUr6rPiDtEWQMimkreLM6EqECWvF8WX1zGk4NnOvPeYnGU5M3jjLTKa0KYYyIbpwMLApohDDD6ZkV1vXMLsSQkjc55NlLsJWTzlBG--fb1CZjdu7CN6ZnzPTB9GJIs-Ebt2acNCR0jkrvD7p8827Kb9OD9Y7yjEHuPd4tZgRsJ7p_u8ePfs4u36xfLy1fOX66eXS6vaMi3RNLJFK4URolLQcFXn77emxgGMUth1ve0lWsCur4eq4wKEGgyvWgREa-V58eiYO8XwcY-U9M7lNsfReAx70ryUqilLmc-_pbwRSoCcpe1RavP4KI9NT9HtTDxoDnomqLf6D4J6JqhB6Ewwe--fyuy7Hfa_nD-RZcHDk8CQNeMQMyxHv3WNEqIu56D1UYd5flcOoybrMIPtXcxgdR_cf7Xz5K8UOzrvcuEPeEDahn30GZDmmrJBv5lXbt44rgBA8kr-AFci290</recordid><startdate>20140430</startdate><enddate>20140430</enddate><creator>Weber, Alexander Mark</creator><creator>Soreni, Noam</creator><creator>Stanley, Jeffrey A</creator><creator>Greco, Alessia</creator><creator>Mendlowitz, Sandra</creator><creator>Szatmari, Peter</creator><creator>Schachar, Russell</creator><creator>Mannasis, Katharina</creator><creator>Pires, Paulo</creator><creator>Swinson, Richard</creator><creator>Noseworthy, Michael D</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140430</creationdate><title>Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive–compulsive disorder</title><author>Weber, Alexander Mark ; Soreni, Noam ; Stanley, Jeffrey A ; Greco, Alessia ; Mendlowitz, Sandra ; Szatmari, Peter ; Schachar, Russell ; Mannasis, Katharina ; Pires, Paulo ; Swinson, Richard ; Noseworthy, Michael D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-ea839ec32a2264081478729a7ef0a44ebbdcd3ec0ebd7f6b12024fa169e0eecc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>1H-MRS</topic><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Child</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Inositol - metabolism</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Fibers, Myelinated - metabolism</topic><topic>Neuroimaging</topic><topic>Obsessive-Compulsive Disorder - metabolism</topic><topic>Obsessive-compulsive disorders</topic><topic>OCD</topic><topic>Pediatric</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychotropic-naïve</topic><topic>Radiology</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weber, Alexander Mark</creatorcontrib><creatorcontrib>Soreni, Noam</creatorcontrib><creatorcontrib>Stanley, Jeffrey A</creatorcontrib><creatorcontrib>Greco, Alessia</creatorcontrib><creatorcontrib>Mendlowitz, Sandra</creatorcontrib><creatorcontrib>Szatmari, Peter</creatorcontrib><creatorcontrib>Schachar, Russell</creatorcontrib><creatorcontrib>Mannasis, Katharina</creatorcontrib><creatorcontrib>Pires, Paulo</creatorcontrib><creatorcontrib>Swinson, Richard</creatorcontrib><creatorcontrib>Noseworthy, Michael D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weber, Alexander Mark</au><au>Soreni, Noam</au><au>Stanley, Jeffrey A</au><au>Greco, Alessia</au><au>Mendlowitz, Sandra</au><au>Szatmari, Peter</au><au>Schachar, Russell</au><au>Mannasis, Katharina</au><au>Pires, Paulo</au><au>Swinson, Richard</au><au>Noseworthy, Michael D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive–compulsive disorder</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res</addtitle><date>2014-04-30</date><risdate>2014</risdate><volume>222</volume><issue>1</issue><spage>67</spage><epage>74</epage><pages>67-74</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>Abstract Obsessive–compulsive disorder (OCD) has a typical onset during childhood or adolescence. Although recent in-vivo proton magnetic resonance spectroscopy (1 H-MRS) studies report gray matter metabolite abnormalities in children and adolescents with OCD, there are no existing1 H-MRS studies that measure white matter (WM) metabolite levels in this population. In the present study, we measured metabolite levels in the left and right prefrontal WM (LPFWM and RPFWM, respectively) of psychotropic-naïve children and adolescents with OCD (LPFWM: N =15, mean age 13.3±2.4 years; right RPFWM: N =14, mean age 13.0±2.3 years) and healthy controls (LPFWM: N =17, mean age 11.8±2.7 years; RPFWM: N =18, mean age 12.2±2.8 years). Spectra were acquired using a 3T single voxel PRESS sequence (1.5×2.0×2.0 cm3 ). When age and sex effects were controlled, OCD patients had higher levels of RPFWM choline and N -acetyl-aspartate (NAA). In addition, RPFWM levels of NAA, creatine and myo-inositol were positively and significantly correlated with severity of OCD symptoms. In summary, this is the first published study of WM metabolite levels in children and adolescents with OCD. Our preliminary findings lend further support to the previous findings of WM abnormalities in OCD.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>24602517</pmid><doi>10.1016/j.pscychresns.2014.02.004</doi><tpages>8</tpages></addata></record> |
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| subjects | 1H-MRS Adolescent Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences Brain Child Choline - metabolism Creatine - metabolism Female Humans Inositol - metabolism Magnetic Resonance Spectroscopy - methods Male Medical sciences Nerve Fibers, Myelinated - metabolism Neuroimaging Obsessive-Compulsive Disorder - metabolism Obsessive-compulsive disorders OCD Pediatric Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotropic-naïve Radiology White matter |
| title | Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive–compulsive disorder |
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