Immunological alterations and associated diseases in mandrills ( Mandrillus sphinx ) naturally co-infected with SIV and STLV
Abstract Mandrills are naturally infected with simian T-cell leukaemia virus type 1 (STLV-1) and simian immunodeficiency virus (SIV)mnd. In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluat...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2014-04, Vol.454, p.184-196 |
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| creator | Souquière, Sandrine Makuwa, Maria Sallé, Bettina Lepelletier, Yves Mortreux, Franck Hermine, Olivier Kazanji, Mirdad |
| description | Abstract Mandrills are naturally infected with simian T-cell leukaemia virus type 1 (STLV-1) and simian immunodeficiency virus (SIV)mnd. In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4+ and CD8+ T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4+ and CD8+ T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates. |
| doi_str_mv | 10.1016/j.virol.2014.02.019 |
| format | Article |
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In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4+ and CD8+ T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4+ and CD8+ T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2014.02.019</identifier><identifier>PMID: 24725945</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Associated diseases ; Cell line ; Co-infection ; Coinfection - complications ; Coinfection - immunology ; Coinfection - veterinary ; Coinfection - virology ; Deltaretrovirus Infections - complications ; Deltaretrovirus Infections - immunology ; Deltaretrovirus Infections - veterinary ; Deltaretrovirus Infections - virology ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human T-lymphotropic virus ; Human T-lymphotropic virus 1 ; Immune system ; Infectious Disease ; Mandrillus ; Mandrillus sphinx ; Primates ; Simian Acquired Immunodeficiency Syndrome - complications ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - pathology ; Simian Acquired Immunodeficiency Syndrome - virology ; Simian immunodeficiency virus ; Simian T-lymphotropic virus 1 ; SIV ; STLV ; T-Lymphocyte Subsets - immunology ; Viral Load</subject><ispartof>Virology (New York, N.Y.), 2014-04, Vol.454, p.184-196</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-3039212af274028b6ba6e1ed05892fc4f3a40c4f32243ba046833743daa8c783</citedby><cites>FETCH-LOGICAL-c492t-3039212af274028b6ba6e1ed05892fc4f3a40c4f32243ba046833743daa8c783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042682214000634$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24725945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souquière, Sandrine</creatorcontrib><creatorcontrib>Makuwa, Maria</creatorcontrib><creatorcontrib>Sallé, Bettina</creatorcontrib><creatorcontrib>Lepelletier, Yves</creatorcontrib><creatorcontrib>Mortreux, Franck</creatorcontrib><creatorcontrib>Hermine, Olivier</creatorcontrib><creatorcontrib>Kazanji, Mirdad</creatorcontrib><title>Immunological alterations and associated diseases in mandrills ( Mandrillus sphinx ) naturally co-infected with SIV and STLV</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract Mandrills are naturally infected with simian T-cell leukaemia virus type 1 (STLV-1) and simian immunodeficiency virus (SIV)mnd. In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4+ and CD8+ T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4+ and CD8+ T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates.</description><subject>Animals</subject><subject>Associated diseases</subject><subject>Cell line</subject><subject>Co-infection</subject><subject>Coinfection - complications</subject><subject>Coinfection - immunology</subject><subject>Coinfection - veterinary</subject><subject>Coinfection - virology</subject><subject>Deltaretrovirus Infections - complications</subject><subject>Deltaretrovirus Infections - immunology</subject><subject>Deltaretrovirus Infections - veterinary</subject><subject>Deltaretrovirus Infections - virology</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Human T-lymphotropic virus</subject><subject>Human T-lymphotropic virus 1</subject><subject>Immune system</subject><subject>Infectious Disease</subject><subject>Mandrillus</subject><subject>Mandrillus sphinx</subject><subject>Primates</subject><subject>Simian Acquired Immunodeficiency Syndrome - complications</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - pathology</subject><subject>Simian Acquired Immunodeficiency Syndrome - virology</subject><subject>Simian immunodeficiency virus</subject><subject>Simian T-lymphotropic virus 1</subject><subject>SIV</subject><subject>STLV</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Viral Load</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsuOEzEQtBCIDQtfgIR8XA4T2o95HUBCKx6Rgjgk2qvleDysg8cO7pmFSHw8nk3gwAVObaurqqWqIuQ5gyUDVr3aL-9cin7Jgckl8CWw9gFZMGirAoRkD8kCQPKiaji_IE8Q95D_dQ2PyQWXNS9bWS7Iz9UwTCH6-MUZ7an2o016dDEg1aGjGjEap0fb0c6h1WiRukCHvEvOe6RX9NP5PSHFw60LP-hLGvQ4Je39kZpYuNBbMyt8d-Mt3axu7pU32_XNU_Ko1x7ts_O8JNv377bXH4v15w-r67frwsiWj4UA0XLGdc9rCbzZVTtdWWY7KJuW90b2QkuYB-dS7DTIqhGilqLTujF1Iy7J1Un2kOK3yeKoBofGeq-DjRMqVgrZlCVU4j-grKoFMFFnqDhBTYqIyfbqkNyg01ExUHNAaq_uA1JzQAq4ygFl1ovzgWk32O4P53ciGfD6BLDZkDtnk0LjbDC2cynbqLro_nHgzV98412Yw_1qjxb3cUohe62YwkxQm7kjc0WYzPWohBS_AE_ntyk</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Souquière, Sandrine</creator><creator>Makuwa, Maria</creator><creator>Sallé, Bettina</creator><creator>Lepelletier, Yves</creator><creator>Mortreux, Franck</creator><creator>Hermine, Olivier</creator><creator>Kazanji, Mirdad</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20140401</creationdate><title>Immunological alterations and associated diseases in mandrills ( Mandrillus sphinx ) naturally co-infected with SIV and STLV</title><author>Souquière, Sandrine ; 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In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4+ and CD8+ T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4+ and CD8+ T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24725945</pmid><doi>10.1016/j.virol.2014.02.019</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Associated diseases Cell line Co-infection Coinfection - complications Coinfection - immunology Coinfection - veterinary Coinfection - virology Deltaretrovirus Infections - complications Deltaretrovirus Infections - immunology Deltaretrovirus Infections - veterinary Deltaretrovirus Infections - virology Human immunodeficiency virus Human immunodeficiency virus 1 Human T-lymphotropic virus Human T-lymphotropic virus 1 Immune system Infectious Disease Mandrillus Mandrillus sphinx Primates Simian Acquired Immunodeficiency Syndrome - complications Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - pathology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian T-lymphotropic virus 1 SIV STLV T-Lymphocyte Subsets - immunology Viral Load |
| title | Immunological alterations and associated diseases in mandrills ( Mandrillus sphinx ) naturally co-infected with SIV and STLV |
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