Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata)

Bioassay-guided fractionation of the fruit powder of graviola (Annona muricata) yielded three novel compounds: muricins J, K, and L. The compounds are all C35 Annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated by spectral methods and chemica...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-06, Vol.24 (12), p.2773-2776
Hauptverfasser:	Sun, Shi, Liu, Jingchun, Kadouh, Hoda, Sun, Xiuxiu, Zhou, Kequan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetogenin Acetogenins - chemistry Acetogenins - isolation & purification Acetogenins - pharmacology Annona - chemistry Annona muricata Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Cell Proliferation - drug effects Chromatography, High Pressure Liquid Cytotoxicity Fruit - chemistry Furans - chemistry Human prostate cancer Humans Magnetic Resonance Spectroscopy Male Molecular Structure Muricin Prostatic Neoplasms - drug therapy
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Zusammenfassung:	Bioassay-guided fractionation of the fruit powder of graviola (Annona muricata) yielded three novel compounds: muricins J, K, and L. The compounds are all C35 Annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and HPLC purification. These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2014.03.099