Synthetic MicroRNA Cassette Dosing: Pharmacokinetics, Tissue Distribution and Bioactivity

MicroRNAs (miRs) are deregulated in cancer and leukemia. Restoring aberrantly downregulated tumor suppressor miRs or antagonizing overexpressed oncogenic miRs in malignant cells by synthetic RNA oligonucleotides represents a potentially novel therapeutic approach in cancer and leukemia. However, giv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmaceutics 2012-06, Vol.9 (6), p.1638-1644
Hauptverfasser:	Wang, Hongyan, Chiu, Ming, Xie, Zhiliang, Chiu, Michael, Liu, Zhongfa, Chen, Ping, Liu, Shujun, Byrd, John C, Muthusamy, Natarajan, Garzon, Ramiro, Croce, Carlo M, Marcucci, Guido, Chan, Kenneth K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Brain - metabolism DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methyltransferase 3A DNA Methyltransferase 3B Enzyme-Linked Immunosorbent Assay Lung - metabolism Male Mice Mice, Inbred C57BL MicroRNAs - chemical synthesis MicroRNAs - chemistry MicroRNAs - pharmacokinetics Myeloid Cell Leukemia Sequence 1 Protein Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!