Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?

Summary Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynurenine (KYN) pathway by the enzyme indoleamine 2,3-dioxygenase (IDO) is implicated in the relation between depression and inflammation. We investigated the role of tryptophan degradation in th...

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Veröffentlicht in:	Psychoneuroendocrinology 2014-07, Vol.45, p.202-210
Hauptverfasser:	Quak, Jacqueline, Doornbos, Bennard, Roest, Annelieke M, Duivis, Hester E, Vogelzangs, Nicole, Nolen, Willem A, Penninx, Brenda W.J.H, Kema, Ido P, de Jonge, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies Aged Behavioral psychophysiology Biological and medical sciences Case-Control Studies Depression Depression - immunology Depression - metabolism Depressive Disorder, Major - immunology Depressive Disorder, Major - metabolism Depressive symptoms Endocrinology & Metabolism Female Fundamental and applied biological sciences. Psychology Hormones and behavior Humans Immune System - metabolism Indoleamine 2,3-dioxygenase Inflammation Inflammation - immunology Inflammation - metabolism Inflammation Mediators - metabolism Kynurenine Kynurenine - metabolism Male Medical sciences Metabolic Networks and Pathways Middle Aged Miscellaneous Mood disorders Netherlands Proteolysis Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Tryptophan Tryptophan - metabolism Young Adult
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