Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
Summary Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynurenine (KYN) pathway by the enzyme indoleamine 2,3-dioxygenase (IDO) is implicated in the relation between depression and inflammation. We investigated the role of tryptophan degradation in th...
Gespeichert in:
| Veröffentlicht in: | Psychoneuroendocrinology 2014-07, Vol.45, p.202-210 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 210 |
|---|---|
| container_issue | |
| container_start_page | 202 |
| container_title | Psychoneuroendocrinology |
| container_volume | 45 |
| creator | Quak, Jacqueline Doornbos, Bennard Roest, Annelieke M Duivis, Hester E Vogelzangs, Nicole Nolen, Willem A Penninx, Brenda W.J.H Kema, Ido P de Jonge, Peter |
| description | Summary Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynurenine (KYN) pathway by the enzyme indoleamine 2,3-dioxygenase (IDO) is implicated in the relation between depression and inflammation. We investigated the role of tryptophan degradation in the relationship between inflammatory markers and depressive symptoms in the Netherlands Study of Depression and Anxiety (NESDA) and hypothesized that tryptophan degradation would mediate (part of) this association. Methods 2812 Participants of NESDA were included in this study including 1042 persons with current major depressive disorder (MDD). Assessments of C-reactive protein (CRP), interleukin (IL)-6, tumor-necrosis factor (TNF)-α, KYN and TRP were obtained from fasting blood samples at the baseline assessment. Tryptophan degradation was estimated by calculating the ratio [KYN/TRP]. Depressive symptoms were measured with the Inventory of Depressive Symptomatology. Results Significant associations between inflammation and depressive symptoms were found for CRP and IL-6, for the total group and the subgroup of patients with current MDD. Adjustment for KYN/TRP did not attenuate these associations. There were no significant indirect effects for CRP on depressive symptoms mediated by KYN/TRP for the whole group ( B = −0.032; 95% CI: −0.103 to 0.028) and for the subgroup of patients with current MDD ( B = 0.059; 95% CI: −0.037 to 0.165). Also IL-6 did not indirectly affect depressive symptoms through KYN/TRP in the total group ( B = −0.023; 95% CI: −0.093 to 0.045) and in the MDD subgroup B = 0.052; 95% CI: −0.019 to 0.144). Finally, no significant relation between depressive symptoms and KYN/TRP was found in the whole group ( β = −0.019, p = 0.311) nor in the subgroup with MDD ( β = 0.025, p = 0.424). Conclusions We did not find indications for tryptophan degradation, measured by KYN/TRP, to mediate the relationship between inflammation and depressive symptoms. |
| doi_str_mv | 10.1016/j.psyneuen.2014.03.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1534851334</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0306453014001097</els_id><sourcerecordid>1534851334</sourcerecordid><originalsourceid>FETCH-LOGICAL-c552t-416838cea86e993355cb01488bf3ade768d5592d190cc0bb543a7b4452ba32273</originalsourceid><addsrcrecordid>eNqNks1u1DAUhSMEokPhFSpvkNgk-H-cDVCVX6kSC2BtOc6djqeJHWxnqrwGT4yHmYLEBlZe-Dv3Hp1zq-qC4IZgIl_umiktHmbwDcWEN5g1mLAH1YqoNasZk_hhtcIMy5oLhs-qJyntMMZSSfq4OqNccUFasqp-vA2QUI7LlMO0NR71cBNNb7ILHpkh-BuUt4BuFz9H8M4Dmkze3pkFjdA7k-HXt0kpWHcUdZDvADyaYqid3wxmHE0OcUFuHOeiNza7vcsLMr4v26YIKbk9oLSMxcOYXj-tHm3MkODZ6T2vvr1_9_XqY339-cOnq8vr2gpBc82JVExZMEpC2zImhO1KEkp1G2Z6WEvVC9HSnrTYWtx1gjOz7jgXtDOM0jU7r14c5xan32dIWY8uWRgG4yHMSRPBuBKEMf4faJlHZatoQeURtTGkFGGjp-hGExdNsD5Up3f6vjp9qE5jpkt1RXhx2jF3JdvfsvuuCvD8BJhkzbCJxluX_nCKq-JDFu7NkYMS3t5B1Mk68Lb0FcFm3Qf3by-v_hphB-dd2XoLC6RdmKMv1WiiE9VYfzkc2uHOCMeY4HbNfgLK99M1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1527326982</pqid></control><display><type>article</type><title>Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Quak, Jacqueline ; Doornbos, Bennard ; Roest, Annelieke M ; Duivis, Hester E ; Vogelzangs, Nicole ; Nolen, Willem A ; Penninx, Brenda W.J.H ; Kema, Ido P ; de Jonge, Peter</creator><creatorcontrib>Quak, Jacqueline ; Doornbos, Bennard ; Roest, Annelieke M ; Duivis, Hester E ; Vogelzangs, Nicole ; Nolen, Willem A ; Penninx, Brenda W.J.H ; Kema, Ido P ; de Jonge, Peter</creatorcontrib><description>Summary Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynurenine (KYN) pathway by the enzyme indoleamine 2,3-dioxygenase (IDO) is implicated in the relation between depression and inflammation. We investigated the role of tryptophan degradation in the relationship between inflammatory markers and depressive symptoms in the Netherlands Study of Depression and Anxiety (NESDA) and hypothesized that tryptophan degradation would mediate (part of) this association. Methods 2812 Participants of NESDA were included in this study including 1042 persons with current major depressive disorder (MDD). Assessments of C-reactive protein (CRP), interleukin (IL)-6, tumor-necrosis factor (TNF)-α, KYN and TRP were obtained from fasting blood samples at the baseline assessment. Tryptophan degradation was estimated by calculating the ratio [KYN/TRP]. Depressive symptoms were measured with the Inventory of Depressive Symptomatology. Results Significant associations between inflammation and depressive symptoms were found for CRP and IL-6, for the total group and the subgroup of patients with current MDD. Adjustment for KYN/TRP did not attenuate these associations. There were no significant indirect effects for CRP on depressive symptoms mediated by KYN/TRP for the whole group ( B = −0.032; 95% CI: −0.103 to 0.028) and for the subgroup of patients with current MDD ( B = 0.059; 95% CI: −0.037 to 0.165). Also IL-6 did not indirectly affect depressive symptoms through KYN/TRP in the total group ( B = −0.023; 95% CI: −0.093 to 0.045) and in the MDD subgroup B = 0.052; 95% CI: −0.019 to 0.144). Finally, no significant relation between depressive symptoms and KYN/TRP was found in the whole group ( β = −0.019, p = 0.311) nor in the subgroup with MDD ( β = 0.025, p = 0.424). Conclusions We did not find indications for tryptophan degradation, measured by KYN/TRP, to mediate the relationship between inflammation and depressive symptoms.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/j.psyneuen.2014.03.013</identifier><identifier>PMID: 24845191</identifier><identifier>CODEN: PSYCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Aged ; Behavioral psychophysiology ; Biological and medical sciences ; Case-Control Studies ; Depression ; Depression - immunology ; Depression - metabolism ; Depressive Disorder, Major - immunology ; Depressive Disorder, Major - metabolism ; Depressive symptoms ; Endocrinology & Metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; Humans ; Immune System - metabolism ; Indoleamine 2,3-dioxygenase ; Inflammation ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation Mediators - metabolism ; Kynurenine ; Kynurenine - metabolism ; Male ; Medical sciences ; Metabolic Networks and Pathways ; Middle Aged ; Miscellaneous ; Mood disorders ; Netherlands ; Proteolysis ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Tryptophan ; Tryptophan - metabolism ; Young Adult</subject><ispartof>Psychoneuroendocrinology, 2014-07, Vol.45, p.202-210</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-416838cea86e993355cb01488bf3ade768d5592d190cc0bb543a7b4452ba32273</citedby><cites>FETCH-LOGICAL-c552t-416838cea86e993355cb01488bf3ade768d5592d190cc0bb543a7b4452ba32273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306453014001097$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28481526$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24845191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quak, Jacqueline</creatorcontrib><creatorcontrib>Doornbos, Bennard</creatorcontrib><creatorcontrib>Roest, Annelieke M</creatorcontrib><creatorcontrib>Duivis, Hester E</creatorcontrib><creatorcontrib>Vogelzangs, Nicole</creatorcontrib><creatorcontrib>Nolen, Willem A</creatorcontrib><creatorcontrib>Penninx, Brenda W.J.H</creatorcontrib><creatorcontrib>Kema, Ido P</creatorcontrib><creatorcontrib>de Jonge, Peter</creatorcontrib><title>Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>Summary Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynurenine (KYN) pathway by the enzyme indoleamine 2,3-dioxygenase (IDO) is implicated in the relation between depression and inflammation. We investigated the role of tryptophan degradation in the relationship between inflammatory markers and depressive symptoms in the Netherlands Study of Depression and Anxiety (NESDA) and hypothesized that tryptophan degradation would mediate (part of) this association. Methods 2812 Participants of NESDA were included in this study including 1042 persons with current major depressive disorder (MDD). Assessments of C-reactive protein (CRP), interleukin (IL)-6, tumor-necrosis factor (TNF)-α, KYN and TRP were obtained from fasting blood samples at the baseline assessment. Tryptophan degradation was estimated by calculating the ratio [KYN/TRP]. Depressive symptoms were measured with the Inventory of Depressive Symptomatology. Results Significant associations between inflammation and depressive symptoms were found for CRP and IL-6, for the total group and the subgroup of patients with current MDD. Adjustment for KYN/TRP did not attenuate these associations. There were no significant indirect effects for CRP on depressive symptoms mediated by KYN/TRP for the whole group ( B = −0.032; 95% CI: −0.103 to 0.028) and for the subgroup of patients with current MDD ( B = 0.059; 95% CI: −0.037 to 0.165). Also IL-6 did not indirectly affect depressive symptoms through KYN/TRP in the total group ( B = −0.023; 95% CI: −0.093 to 0.045) and in the MDD subgroup B = 0.052; 95% CI: −0.019 to 0.144). Finally, no significant relation between depressive symptoms and KYN/TRP was found in the whole group ( β = −0.019, p = 0.311) nor in the subgroup with MDD ( β = 0.025, p = 0.424). Conclusions We did not find indications for tryptophan degradation, measured by KYN/TRP, to mediate the relationship between inflammation and depressive symptoms.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Depression</subject><subject>Depression - immunology</subject><subject>Depression - metabolism</subject><subject>Depressive Disorder, Major - immunology</subject><subject>Depressive Disorder, Major - metabolism</subject><subject>Depressive symptoms</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>Humans</subject><subject>Immune System - metabolism</subject><subject>Indoleamine 2,3-dioxygenase</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation Mediators - metabolism</subject><subject>Kynurenine</subject><subject>Kynurenine - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Networks and Pathways</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Netherlands</subject><subject>Proteolysis</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Tryptophan</subject><subject>Tryptophan - metabolism</subject><subject>Young Adult</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhSMEokPhFSpvkNgk-H-cDVCVX6kSC2BtOc6djqeJHWxnqrwGT4yHmYLEBlZe-Dv3Hp1zq-qC4IZgIl_umiktHmbwDcWEN5g1mLAH1YqoNasZk_hhtcIMy5oLhs-qJyntMMZSSfq4OqNccUFasqp-vA2QUI7LlMO0NR71cBNNb7ILHpkh-BuUt4BuFz9H8M4Dmkze3pkFjdA7k-HXt0kpWHcUdZDvADyaYqid3wxmHE0OcUFuHOeiNza7vcsLMr4v26YIKbk9oLSMxcOYXj-tHm3MkODZ6T2vvr1_9_XqY339-cOnq8vr2gpBc82JVExZMEpC2zImhO1KEkp1G2Z6WEvVC9HSnrTYWtx1gjOz7jgXtDOM0jU7r14c5xan32dIWY8uWRgG4yHMSRPBuBKEMf4faJlHZatoQeURtTGkFGGjp-hGExdNsD5Up3f6vjp9qE5jpkt1RXhx2jF3JdvfsvuuCvD8BJhkzbCJxluX_nCKq-JDFu7NkYMS3t5B1Mk68Lb0FcFm3Qf3by-v_hphB-dd2XoLC6RdmKMv1WiiE9VYfzkc2uHOCMeY4HbNfgLK99M1</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Quak, Jacqueline</creator><creator>Doornbos, Bennard</creator><creator>Roest, Annelieke M</creator><creator>Duivis, Hester E</creator><creator>Vogelzangs, Nicole</creator><creator>Nolen, Willem A</creator><creator>Penninx, Brenda W.J.H</creator><creator>Kema, Ido P</creator><creator>de Jonge, Peter</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20140701</creationdate><title>Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?</title><author>Quak, Jacqueline ; Doornbos, Bennard ; Roest, Annelieke M ; Duivis, Hester E ; Vogelzangs, Nicole ; Nolen, Willem A ; Penninx, Brenda W.J.H ; Kema, Ido P ; de Jonge, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-416838cea86e993355cb01488bf3ade768d5592d190cc0bb543a7b4452ba32273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Depression</topic><topic>Depression - immunology</topic><topic>Depression - metabolism</topic><topic>Depressive Disorder, Major - immunology</topic><topic>Depressive Disorder, Major - metabolism</topic><topic>Depressive symptoms</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and behavior</topic><topic>Humans</topic><topic>Immune System - metabolism</topic><topic>Indoleamine 2,3-dioxygenase</topic><topic>Inflammation</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation Mediators - metabolism</topic><topic>Kynurenine</topic><topic>Kynurenine - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Networks and Pathways</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Netherlands</topic><topic>Proteolysis</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Tryptophan</topic><topic>Tryptophan - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quak, Jacqueline</creatorcontrib><creatorcontrib>Doornbos, Bennard</creatorcontrib><creatorcontrib>Roest, Annelieke M</creatorcontrib><creatorcontrib>Duivis, Hester E</creatorcontrib><creatorcontrib>Vogelzangs, Nicole</creatorcontrib><creatorcontrib>Nolen, Willem A</creatorcontrib><creatorcontrib>Penninx, Brenda W.J.H</creatorcontrib><creatorcontrib>Kema, Ido P</creatorcontrib><creatorcontrib>de Jonge, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quak, Jacqueline</au><au>Doornbos, Bennard</au><au>Roest, Annelieke M</au><au>Duivis, Hester E</au><au>Vogelzangs, Nicole</au><au>Nolen, Willem A</au><au>Penninx, Brenda W.J.H</au><au>Kema, Ido P</au><au>de Jonge, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>45</volume><spage>202</spage><epage>210</epage><pages>202-210</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><coden>PSYCDE</coden><abstract>Summary Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynurenine (KYN) pathway by the enzyme indoleamine 2,3-dioxygenase (IDO) is implicated in the relation between depression and inflammation. We investigated the role of tryptophan degradation in the relationship between inflammatory markers and depressive symptoms in the Netherlands Study of Depression and Anxiety (NESDA) and hypothesized that tryptophan degradation would mediate (part of) this association. Methods 2812 Participants of NESDA were included in this study including 1042 persons with current major depressive disorder (MDD). Assessments of C-reactive protein (CRP), interleukin (IL)-6, tumor-necrosis factor (TNF)-α, KYN and TRP were obtained from fasting blood samples at the baseline assessment. Tryptophan degradation was estimated by calculating the ratio [KYN/TRP]. Depressive symptoms were measured with the Inventory of Depressive Symptomatology. Results Significant associations between inflammation and depressive symptoms were found for CRP and IL-6, for the total group and the subgroup of patients with current MDD. Adjustment for KYN/TRP did not attenuate these associations. There were no significant indirect effects for CRP on depressive symptoms mediated by KYN/TRP for the whole group ( B = −0.032; 95% CI: −0.103 to 0.028) and for the subgroup of patients with current MDD ( B = 0.059; 95% CI: −0.037 to 0.165). Also IL-6 did not indirectly affect depressive symptoms through KYN/TRP in the total group ( B = −0.023; 95% CI: −0.093 to 0.045) and in the MDD subgroup B = 0.052; 95% CI: −0.019 to 0.144). Finally, no significant relation between depressive symptoms and KYN/TRP was found in the whole group ( β = −0.019, p = 0.311) nor in the subgroup with MDD ( β = 0.025, p = 0.424). Conclusions We did not find indications for tryptophan degradation, measured by KYN/TRP, to mediate the relationship between inflammation and depressive symptoms.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24845191</pmid><doi>10.1016/j.psyneuen.2014.03.013</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4530 |
| ispartof | Psychoneuroendocrinology, 2014-07, Vol.45, p.202-210 |
| issn | 0306-4530 1873-3360 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1534851334 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Adult and adolescent clinical studies Aged Behavioral psychophysiology Biological and medical sciences Case-Control Studies Depression Depression - immunology Depression - metabolism Depressive Disorder, Major - immunology Depressive Disorder, Major - metabolism Depressive symptoms Endocrinology & Metabolism Female Fundamental and applied biological sciences. Psychology Hormones and behavior Humans Immune System - metabolism Indoleamine 2,3-dioxygenase Inflammation Inflammation - immunology Inflammation - metabolism Inflammation Mediators - metabolism Kynurenine Kynurenine - metabolism Male Medical sciences Metabolic Networks and Pathways Middle Aged Miscellaneous Mood disorders Netherlands Proteolysis Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Tryptophan Tryptophan - metabolism Young Adult |
| title | Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T19%3A16%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20tryptophan%20degradation%20along%20the%20kynurenine%20pathway%20mediate%20the%20association%20between%20pro-inflammatory%20immune%20activity%20and%20depressive%20symptoms?&rft.jtitle=Psychoneuroendocrinology&rft.au=Quak,%20Jacqueline&rft.date=2014-07-01&rft.volume=45&rft.spage=202&rft.epage=210&rft.pages=202-210&rft.issn=0306-4530&rft.eissn=1873-3360&rft.coden=PSYCDE&rft_id=info:doi/10.1016/j.psyneuen.2014.03.013&rft_dat=%3Cproquest_cross%3E1534851334%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1527326982&rft_id=info:pmid/24845191&rft_els_id=1_s2_0_S0306453014001097&rfr_iscdi=true |