G/U and Certain Wobble Position Mismatches as Possible Main Causes of Amino Acid Misincorporations

A mass spectrometry-based method was developed to measure amino acid substitutions directly in proteins down to a level of 0.001%. When applied to recombinant proteins expressed in Escherichia coli, monoclonal antibodies expressed in mammalian cells, and human serum albumin purified from three human...

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Veröffentlicht in:	Biochemistry (Easton) 2013-11, Vol.52 (45), p.8165-8176
Hauptverfasser:	Zhang, Zhongqi, Shah, Bhavana, Bondarenko, Pavel V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Anticodon - chemistry Codon - chemistry Escherichia coli Escherichia coli - genetics RNA, Transfer - chemistry
Online-Zugang:	Volltext
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