A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse
A distinctive alteration of speech has been reported in patients suffering from ephedrone-induced parkinsonism. However, an objective assessment of dysarthria has not been performed in ephedrone users. We studied 28 young Caucasian men from Georgia with a previous history of ephedrone abuse and comp...
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| Veröffentlicht in: | Journal of Neural Transmission 2014-06, Vol.121 (6), p.655-664 |
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| creator | Rusz, Jan Megrelishvili, Marika Bonnet, Cecilia Okujava, Michael Brožová, Hana Khatiashvili, Irine Sekhniashvili, Madona Janelidze, Marina Tolosa, Eduardo Růžička, Evžen |
| description | A distinctive alteration of speech has been reported in patients suffering from ephedrone-induced parkinsonism. However, an objective assessment of dysarthria has not been performed in ephedrone users. We studied 28 young Caucasian men from Georgia with a previous history of ephedrone abuse and compared them to 25 age-matched healthy controls. Speech examination, brain MRI, and NNIPPS-Parkinson plus scale were performed in all patients. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analyses of 15 speech dimensions. We revealed a distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedrone-induced parkinsonism. According to acoustic analyses, all patients presented at least one affected speech dimension, whereas dysarthria was moderate in 43 % and severe in 36 % of patients. Further findings indicated relationships between motor subscores of dystonia and bradykinesia and speech components of loudness (
r
= −0.54,
p
|
| doi_str_mv | 10.1007/s00702-014-1158-6 |
| format | Article |
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r
= −0.54,
p
< 0.01), articulation (
r
= 0.40,
p
< 0.05), and timing (
r
= −0.53,
p
< 0.01). In ephedrone-induced parkinsonism a prominent mixed hyperkinetic–hypokinetic dysarthria occurs that appears related to marked dystonia and bradykinesia and probably reflects manganese induced toxic and neurodegenerative damage to the globus pallidus internus and substantia nigra.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/s00702-014-1158-6</identifier><identifier>PMID: 24445755</identifier><identifier>CODEN: JNTRF3</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Acoustics ; Adult ; Analysis of Variance ; Antiparkinson Agents - therapeutic use ; Dysarthria - etiology ; Dystonia - etiology ; Humans ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Mental Status Schedule ; Middle Aged ; Neurology ; Neurology and Preclinical Neurological Studies - Original Article ; Neurosciences ; Parkinsonian Disorders - drug therapy ; Parkinsonian Disorders - etiology ; Propiophenones - adverse effects ; Psychiatry ; Severity of Illness Index ; Statistics as Topic ; Substance-Related Disorders - complications</subject><ispartof>Journal of Neural Transmission, 2014-06, Vol.121 (6), p.655-664</ispartof><rights>Springer-Verlag Wien 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-fb731859e3fbf7c60e1ce891e956969581229bd55e81b9fe9e617c27303f731e3</citedby><cites>FETCH-LOGICAL-c405t-fb731859e3fbf7c60e1ce891e956969581229bd55e81b9fe9e617c27303f731e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00702-014-1158-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00702-014-1158-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24445755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rusz, Jan</creatorcontrib><creatorcontrib>Megrelishvili, Marika</creatorcontrib><creatorcontrib>Bonnet, Cecilia</creatorcontrib><creatorcontrib>Okujava, Michael</creatorcontrib><creatorcontrib>Brožová, Hana</creatorcontrib><creatorcontrib>Khatiashvili, Irine</creatorcontrib><creatorcontrib>Sekhniashvili, Madona</creatorcontrib><creatorcontrib>Janelidze, Marina</creatorcontrib><creatorcontrib>Tolosa, Eduardo</creatorcontrib><creatorcontrib>Růžička, Evžen</creatorcontrib><title>A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm</addtitle><addtitle>J Neural Transm (Vienna)</addtitle><description>A distinctive alteration of speech has been reported in patients suffering from ephedrone-induced parkinsonism. However, an objective assessment of dysarthria has not been performed in ephedrone users. We studied 28 young Caucasian men from Georgia with a previous history of ephedrone abuse and compared them to 25 age-matched healthy controls. Speech examination, brain MRI, and NNIPPS-Parkinson plus scale were performed in all patients. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analyses of 15 speech dimensions. We revealed a distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedrone-induced parkinsonism. According to acoustic analyses, all patients presented at least one affected speech dimension, whereas dysarthria was moderate in 43 % and severe in 36 % of patients. Further findings indicated relationships between motor subscores of dystonia and bradykinesia and speech components of loudness (
r
= −0.54,
p
< 0.01), articulation (
r
= 0.40,
p
< 0.05), and timing (
r
= −0.53,
p
< 0.01). In ephedrone-induced parkinsonism a prominent mixed hyperkinetic–hypokinetic dysarthria occurs that appears related to marked dystonia and bradykinesia and probably reflects manganese induced toxic and neurodegenerative damage to the globus pallidus internus and substantia nigra.</description><subject>Acoustics</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Dysarthria - etiology</subject><subject>Dystonia - etiology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental Status Schedule</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neurology and Preclinical Neurological Studies - Original Article</subject><subject>Neurosciences</subject><subject>Parkinsonian Disorders - drug therapy</subject><subject>Parkinsonian Disorders - etiology</subject><subject>Propiophenones - adverse effects</subject><subject>Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Statistics as Topic</subject><subject>Substance-Related Disorders - complications</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9P3DAQxa2qqLtAP0AvyBKXXgIe_89xtWoLElIvcDZOMinZbpzFdhB8-xqWVgipl7HG_r0340fIF2BnwJg5T6UwXjGQFYCylf5AliCFqkBq8ZEsmWCsqpWWC3KY0oYxBmDsJ7LgUkpllFqS2xXthpSH0Gb64OPgQ6ZTT8fhETvaPSUf8125pRH7LbY50Z2Pv4eQpjCkkfrwAuXSedrNSPNEcXeHXZwCUt_MCY_JQe-3CT-_nkfk5vu36_VFdfXzx-V6dVW1kqlc9Y0RYFWNom9602qG0KKtAcv6ta6VBc7rplMKLTR1jzVqMC03gom-KFEcka97312c7mdM2Y1DanG79QGnOTlQQlppgLOCnr5DN9McQ9muUFxrC4bbQsGeauOUUvm_28Vh9PHJAXPP8bt9_K7E757jd7poTl6d52bE7p_ib94F4HsglafwC-Ob0f91_QM5-Y99</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Rusz, Jan</creator><creator>Megrelishvili, Marika</creator><creator>Bonnet, Cecilia</creator><creator>Okujava, Michael</creator><creator>Brožová, Hana</creator><creator>Khatiashvili, Irine</creator><creator>Sekhniashvili, Madona</creator><creator>Janelidze, Marina</creator><creator>Tolosa, Eduardo</creator><creator>Růžička, Evžen</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7TK</scope></search><sort><creationdate>20140601</creationdate><title>A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse</title><author>Rusz, Jan ; Megrelishvili, Marika ; Bonnet, Cecilia ; Okujava, Michael ; Brožová, Hana ; Khatiashvili, Irine ; Sekhniashvili, Madona ; Janelidze, Marina ; Tolosa, Eduardo ; Růžička, Evžen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-fb731859e3fbf7c60e1ce891e956969581229bd55e81b9fe9e617c27303f731e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acoustics</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Antiparkinson Agents - therapeutic use</topic><topic>Dysarthria - etiology</topic><topic>Dystonia - etiology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental Status Schedule</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neurology and Preclinical Neurological Studies - Original Article</topic><topic>Neurosciences</topic><topic>Parkinsonian Disorders - drug therapy</topic><topic>Parkinsonian Disorders - etiology</topic><topic>Propiophenones - adverse effects</topic><topic>Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Statistics as Topic</topic><topic>Substance-Related Disorders - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rusz, Jan</creatorcontrib><creatorcontrib>Megrelishvili, Marika</creatorcontrib><creatorcontrib>Bonnet, Cecilia</creatorcontrib><creatorcontrib>Okujava, Michael</creatorcontrib><creatorcontrib>Brožová, Hana</creatorcontrib><creatorcontrib>Khatiashvili, Irine</creatorcontrib><creatorcontrib>Sekhniashvili, Madona</creatorcontrib><creatorcontrib>Janelidze, Marina</creatorcontrib><creatorcontrib>Tolosa, Eduardo</creatorcontrib><creatorcontrib>Růžička, Evžen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rusz, Jan</au><au>Megrelishvili, Marika</au><au>Bonnet, Cecilia</au><au>Okujava, Michael</au><au>Brožová, Hana</au><au>Khatiashvili, Irine</au><au>Sekhniashvili, Madona</au><au>Janelidze, Marina</au><au>Tolosa, Eduardo</au><au>Růžička, Evžen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse</atitle><jtitle>Journal of Neural Transmission</jtitle><stitle>J Neural Transm</stitle><addtitle>J Neural Transm (Vienna)</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>121</volume><issue>6</issue><spage>655</spage><epage>664</epage><pages>655-664</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTRF3</coden><abstract>A distinctive alteration of speech has been reported in patients suffering from ephedrone-induced parkinsonism. However, an objective assessment of dysarthria has not been performed in ephedrone users. We studied 28 young Caucasian men from Georgia with a previous history of ephedrone abuse and compared them to 25 age-matched healthy controls. Speech examination, brain MRI, and NNIPPS-Parkinson plus scale were performed in all patients. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analyses of 15 speech dimensions. We revealed a distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedrone-induced parkinsonism. According to acoustic analyses, all patients presented at least one affected speech dimension, whereas dysarthria was moderate in 43 % and severe in 36 % of patients. Further findings indicated relationships between motor subscores of dystonia and bradykinesia and speech components of loudness (
r
= −0.54,
p
< 0.01), articulation (
r
= 0.40,
p
< 0.05), and timing (
r
= −0.53,
p
< 0.01). In ephedrone-induced parkinsonism a prominent mixed hyperkinetic–hypokinetic dysarthria occurs that appears related to marked dystonia and bradykinesia and probably reflects manganese induced toxic and neurodegenerative damage to the globus pallidus internus and substantia nigra.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>24445755</pmid><doi>10.1007/s00702-014-1158-6</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acoustics Adult Analysis of Variance Antiparkinson Agents - therapeutic use Dysarthria - etiology Dystonia - etiology Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Mental Status Schedule Middle Aged Neurology Neurology and Preclinical Neurological Studies - Original Article Neurosciences Parkinsonian Disorders - drug therapy Parkinsonian Disorders - etiology Propiophenones - adverse effects Psychiatry Severity of Illness Index Statistics as Topic Substance-Related Disorders - complications |
| title | A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse |
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