Gene Expression Profiles in the Fetal Mouse Brain after Etoposide (VP-16) Administration

The aim of this study was to analyze the response of gene expression caused by etoposide (VP-16) in the fetal mouse brain. Four miligrams/kilogram of VP-16 was intraperitoneally injected into pregnant mice on day 12 of gestation (GD 12). Gene expression profiling of the VP-16-treated fetal mouse bra...

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Veröffentlicht in:	Experimental Animals 2013, Vol.62(2), pp.93-99
Hauptverfasser:	NAM, Chunja, YAMAUCHI, Hirofumi, HE, Xi Jun, WOO, Gye-Hyeong, AHN, Byeongwoo, NAM, Sang-Yoon, DOI, Kunio, NAKAYAMA, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism Antineoplastic Agents, Phytogenic - adverse effects apoptosis Apoptosis - drug effects Apoptosis - genetics Brain - cytology Brain - embryology Brain - pathology cell cycle arrest Cell Cycle Checkpoints - drug effects Cell Cycle Checkpoints - genetics DNA Damage - drug effects DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - metabolism etoposide (VP-16) Etoposide - administration & dosage Etoposide - adverse effects Female Gene Expression Regulation, Developmental - drug effects Genes, p53 - genetics Injections, Intraperitoneal Mitochondria - genetics Mitochondria - physiology neuroepithelial cell Neuroepithelial Cells - pathology p53 Pregnancy Transcriptome - drug effects Up-Regulation - drug effects
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