Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats

Abstract Background Increased myocyte apoptosis in diabetic hearts has been previously reported. The purpose of this study was to evaluate the effects of exercise training on cardiac survival pathways in streptozotocin (STZ)-induced diabetic rats. Methods Forty-eight male Wistar rats were randomly d...

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Veröffentlicht in:	International journal of cardiology 2013-07, Vol.167 (2), p.478-485
Hauptverfasser:	Cheng, Shiu-Min, Ho, Tsung-Jung, Yang, Ai-Lun, Chen, I-Ju, Kao, Chung-Lan, Wu, Fan-Ni, Lin, James A, Kuo, Chia-Hua, Ou, Hsiu-Chung, Huang, Chih-Yang, Lee, Shin-Da
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl-2 Biological and medical sciences Cardiology. Vascular system Cardiovascular Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - mortality Diabetes Mellitus, Experimental - therapy Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Heart Heart Ventricles - metabolism IGFI-R/PI3K/Akt survival pathway Insulin-Like Growth Factor I - metabolism Male Medical sciences Phosphatidylinositol 3-Kinase - metabolism Physical Conditioning, Animal - methods Physical Conditioning, Animal - physiology Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Random Allocation Rats Rats, Wistar Receptor, IGF Type 1 - metabolism Survival Rate - trends
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